Proteomic analysis of the failing human heart by mass spectrometry
| Project/Area Number |
15K20942
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
Laboratory medicine
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Domoto Yukako 東京大学, 医学部附属病院, 特任講師 (30596961)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 心臓 / プロテオミクス / プロテオミクス解析 / 質量解析 / 左室補助人工心臓 |
|---|
| Outline of Final Research Achievements |
A left ventricular assist device (LVAD) is used for patients with heart failure as a bridge to heart transplantation. To reveal the molecular markers that are associated with an improvement of cardiac function and myocardial remodeling, the myocardial tissue from patients with heart failure was analyzed with liquid-chromatography mass spectrometry. As the first step to gain the candidates of prognostic markers, we tried finding the myocardial proteins in which change was observed following LVAD support. For each patient, we quantified at least 1,000 different kinds of protein in this study. This proteomics approach suggests that mitochondrial proteins are convincing markers to characterize the molecular changes in myocardium during the course of LVAD support.
|
Report
(3 results)
Research Products
(9 results)
-
[Journal Article] Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients2017
Author(s)
Yukako Shintani-Domoto, Takahiro Hayasaka, Daichi Maeda, Noritaka Masaki, Takashi K. Ito, Kei Sakuma, Michio Tanaka, Katsuya Kabashima, Shiro Takei, Mitsutoshi Setou, Masashi Fukayama
-
Journal Title
BBA - Proteins and Proteomics
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
[Journal Article] Fukutin gene mutations that cause left ventricular noncompaction.2016
Author(s)
Amiya E, Morita H, Hatano M, Nitta D, Hosoya Y, Maki H, Motozawa Y, Sato N, Ishiura H, Numakura S, Shintani Y, Kinugawa K, Takeda N, Shimizu J, Tsuji S, Komuro I.
-
Journal Title
Int J Cardiol.
Volume: 222
Pages: 727-729
Related Report
Peer Reviewed
-
-
