| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To examine the fragility of irradiated vertebral bone, we performed a mechanical stress tests and structure analysis by μCT on irradiated rat vertebrae. Rats received a single external irradiation of 20 Gy on the lumbar vertebra using a small animal irradiation apparatus. After irradiation, they were sacrificed the irradiated vertebrae were excised. We performed the vertebral body compression load test and μCT analyses of the vertebrae. Bone strength was significantly lower in the irradiated group than in the non-irradiated group. In μCT analyses, reduced trabecular connectivity were observed in the irradiated group as compared with the non-irradiated group. The three-dimensional structure was coarse in the irradiated group. However, bone mineral densities of the 2 group were almost the same. The results of this study indivated that the microstructure changes of cancellous bone in the radiated vertebrae led to a decrease in bone strength without a change in bone density.
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