Construction of a technology controlling specific cells using bacterial nanoparticles.
| Project/Area Number |
15K21043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
Modeling and technologies for environmental conservation and remediation
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ナノ粒子 / ベシクル / 微生物 / 水平伝播 |
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| Outline of Final Research Achievements |
In this study, the specificity of the membrane vesicle (MV)-cell interactions was investigated and the potential of MVs to target bacterial cells for delivery was evaluated. MVs derived from the enterobacterium specifically interacted with cells of the parent strain, but interacted less specifically with the other species tested in this study. The specific interaction of MVs with bacterial cells was explained in terms of interaction energy. Moreover, the specific interaction enabled the use of antibiotic-associated MVs to effectively kill target bacterial species. Altogether, this study provides the evidence that MVs selectively interact with target bacterial cells and offer a new avenue for controlling specific bacterial species using bacterial MVs in microbial communities.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Interspecies interactions are an integral determinant of microbial community dynamics2015
Author(s)
2. Fatma Azwani Abdul Aziz*, Kenshi Suzuki, Akihiro Ohtaki, Keita Sagegami, Hidetaka Hirai, Jun Seno, Naoko Mizuno, Yuma Inuzuka, Yasuhisa Saito, Yosuke Tashiro, Akira Hiraishi and Hiroyuki Futamata
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Journal Title
Frontiers in Microbiology
Volume: 6
Pages: 1148-1148
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Inhibition of Pseudomonas aeruginosa Swarming Motility by 1-Naphthol and Other Bicyclic Compounds Bearing Hydroxyl Groups2015
Author(s)
Oura H, Tashiro Y, Toyofuku M, Ueda K, Kiyokawa T, Ito S, Takahashi Y, Lee S, Nojiri H, Nakajima-Kambe T, Uchiyama H, Futamata H and Nomura N.
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Journal Title
Applied and Environmental Microbiology
Volume: 81(8)
Issue: 8
Pages: 2808-2818
DOI
Related Report
Peer Reviewed
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