| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, the specificity of the membrane vesicle (MV)-cell interactions was investigated and the potential of MVs to target bacterial cells for delivery was evaluated. MVs derived from the enterobacterium specifically interacted with cells of the parent strain, but interacted less specifically with the other species tested in this study. The specific interaction of MVs with bacterial cells was explained in terms of interaction energy. Moreover, the specific interaction enabled the use of antibiotic-associated MVs to effectively kill target bacterial species. Altogether, this study provides the evidence that MVs selectively interact with target bacterial cells and offer a new avenue for controlling specific bacterial species using bacterial MVs in microbial communities.
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