| Project/Area Number |
15K21052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
Cardiovascular surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Sano Masaki 浜松医科大学, 医学部附属病院, 診療助教 (40733514)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 二次性リンパ浮腫 / エイコサペンタエン酸 / 皮膚線維化 / 筋線維芽細胞 / リンパ浮腫モデル / リンパ浮腫 / ＴＧＦ－β / エイコサペント酸エチル |
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| Outline of Final Research Achievements |
We developed a rat model of secondary lymphedema.Our model showed increase of limb volume, accumulation of lymphatic fluid, increase of collagen and skin hardness. Our lymphedma model mimic to human lymphedema patients, Using our model, we showed myofibroblasts exist in skin tissues of lymphedema model and accelerate collagen synthesis to result in fibrosis. Moreover, eicosapentaenoic acid (EPA) prevent skin fibrosis in vitro study. Similar findings were observed in skin samples from lymphedema patients. EPA may be useful in inhibiting fibrosis in patients with secondary lymphedema.
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