| Project/Area Number |
15K21070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
Kanie Kei 名古屋大学, 創薬科学研究科, 助教 (80636407)
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| Research Collaborator |
KATO Ryuji 名古屋大学, 大学院創薬科学研究科, 准教授
EBARA Mitsuhiro 物質・材料研究機構, MANAナノシステム分野, MANA准主任研究者
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ペプチド / 人工血管 / バイオマテリアル / 内皮細胞 / 高分子材料 / コラーゲンIV / 間葉系幹細胞 / 骨再生 / 細胞外マトリックス / 細胞接着 / サイトカイン / 骨分化 / 平滑筋細胞 |
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| Outline of Final Research Achievements |
Aim of this study is obtaining short selective-peptides for enhancing the effect of artificial blood vessel. There are two detail aims, one is screening ECM-selective adhesion peptides, and another is screening endotherial cell(EC)-selective adhesion peptides. As a result, some Collagen IV-selective peptides and EC-selective peptides were successfully obtained in this two years. Additionally, combination of peptide and polymeric materials could control the EC-selectivity.
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