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in vivo applications of next-generation DDS carrier for achieving less-invasive radiation therapy

Research Project

Project/Area Number 15K21156
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Biomedical engineering/Biomaterial science and engineering
Research InstitutionKobe University

Principal Investigator

Nishimura Yuya  神戸大学, 科学技術イノベーション研究科, 特命助教 (40728218)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsドラッグデリバリーシステム / バイオナノカプセル / 抗癌剤ドキソルビシン / 放射線増感剤 / ナノ粒子 / 放射線治療 / Affibody / in vivo / 無機ナノ粒子
Outline of Final Research Achievements

We have developed bio-nanocapsule derived from hepatitis B virus as a carrier for drug delivery system and achieved some progress in vitro. Therefore, to apply this carrier in a clinical application, we demonstrated availability in vivo. As the result, delivery of anticancer drug (doxorubicin) showed antitumor effect in mouse xenograft models. Next, we measured time course of biodistribution of PAATiOx with radiosensitization efficacy and showed accumulation within the tumor. Then, in combination with X-irradiation, antitumor effect was observed. Therefore, we indicated that this carrier is available in vivo.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Affibody-displaying bio-nanocapsules effective in EGFR, typical biomarker, expressed in various cancer cells2017

    • Author(s)
      Yuya Nishimura, Ryosuke Ezawa, Jun Ishii, Chiaki Ogino, Akihiko Kondo
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27(2) Issue: 2 Pages: 336-341

    • DOI

      10.1016/j.bmcl.2016.11.038

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel Radiosensitizer,2016

    • Author(s)
      Morita K, Miyazaki S, Numaki C, Ikeno S, Sasaki R, Nishimura Y, Ogino C, Kondo A,
    • Journal Title

      Free Radical Research,

      Volume: 50(12) Issue: 12 Pages: 1319-1328

    • DOI

      10.1080/10715762.2016.1241879

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Less-invasive anticancer efficacy by a combination of bio-nanocapsule/liposome complex and radiation therapy2016

    • Author(s)
      Yuya Nishimura, Takahiro Suzuki, Kenta Morita, Masao Nakayama, Sachiko Inubushi, Chiya Numako, Chiaki Ogino, Ryohei Sasaki, Akihiko Kondo
    • Organizer
      International Biotechnology Symposium 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-10-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HER2受容体発現細胞を標的としたDDSキャリアの抗腫瘍効果の評価2016

    • Author(s)
      西村勇哉、鈴木貴弘、森田健太、荻野千秋、近藤昭彦
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2016
    • Place of Presentation
      ホテルコンチネンタル府中(東京都府中市)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Affibody提示バイオナノカプセル/リポソーム融合粒子を用いたin vivoでの抗腫瘍効果2016

    • Author(s)
      西村勇哉、鈴木貴弘、森田健太、荻野千秋、近藤昭彦
    • Organizer
      化学工学会 第81年会(2016)
    • Place of Presentation
      関西大学 千里山キャンパス
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Specific drug delivery for target cancer tumor using affibody-displaying bio-nanocapsule/liposome complex2015

    • Author(s)
      Yuya Nishimura, Jun Ishii, Chiaki Ogino, Akihiko Kondo
    • Organizer
      PACIFICHEM 2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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