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Pathogenicity of Avian Infuenza Virus Isolates in Vietnam to domestic ducks

Research Project

Project/Area Number 15K21168
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Animal production science
Research InstitutionTottori University

Principal Investigator

SODA Kosuke  鳥取大学, 農学部, 講師 (00582983)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords鳥インフルエンザ / アヒル / 病原性 / 重感染 / ベトナム / 日本
Outline of Final Research Achievements

Highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza virus (LPAIV) have been co-circulating in domestic poultry populations in Vietnam. In the present study, we examined whether pathogenicity of HPAIV was affected by co-infection with LPAIV. Upon result, HPAIV showed reduced pathogenicity in domestic ducks with prior infection of LPAIV. Cross-antigenicity between inoculated viruses and/or innate immunity induced by prior LPAIV infection might be involved in the phenomenon.

Academic Significance and Societal Importance of the Research Achievements

高病原性鳥インフルエンザウイルス(HPAIV)と並行して低病原性鳥インフルエンザウイルス(LPAIV)が家禽で流行している国が、アジア各国を中心に認められている。本研究により、HPAIVによる症状の顕在化がLPAIVの流行により抑えられ、HPAIVが浸潤している家禽群の同定を困難にしていることが示された。HPAIVの排除には、LPAIVのコントロールも併せて必要であると考えられ、本成果は今後の鳥インフルエンザ対策において有効な手段を講じていく上で強力な科学的根拠となる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (16 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Characterization of Highly Pathogenic Avian Influenza Virus A(H5N6), Japan, November 2016.2017

    • Author(s)
      (8)Okamatsu, M., Ozawa, M., Soda, K., Takakuwa, H., Haga, A., Hiono, T., Matsuu, A., Uchida, Y., Iwata, R., Matsuno, K., Kuwahara, M., Yabuta, T., Usui, T., Ito, H., Onuma, M., Sakoda, Y., Saito, T., Otsuki, K., Ito, T., Kida, H.
    • Journal Title

      Emerging Infectious Diseases

      Volume: 23(4) Issue: 4 Pages: 691-695

    • DOI

      10.3201/eid2304.161957

    • NAID

      120006337764

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016/20172017

    • Author(s)
      Nobuhiro Takemae、Ryota Tsunekuni、Kirill Sharshov、Taichiro Tanikawa、Yuko Uchida、Hiroshi Ito、Kosuke Soda、Tatsufumi Usui、Ivan Sobolev、Alexander Shestopalov、Tsuyoshi Yamaguchi、Junki Mine、Toshihiro Ito、Takehiko Saito
    • Journal Title

      Virology

      Volume: 512 Pages: 8-20

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ベトナムの家禽由来H5亜型高病原性鳥インフルエンザウイルスに対する抗体保有状況2018

    • Author(s)
      永菅麻依子、曽田公輔、仲村 望、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、Le Quynh Mai、伊藤壽啓
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ベトナムの家禽から分離されたclade2.3.4.4 H5亜型高病原性鳥インフルエンザウイルスのアヒルに対する病原性2018

    • Author(s)
      曽田公輔、山根真弥、伊藤啓史、伊藤壽啓
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clade 2.3.4.4 H5 highly pathogenic avian influenza viruses showed various pathogenicity in domestic ducks2018

    • Author(s)
      Kosuke Soda, Maya Yamane, Hiroshi Ito, Toshihiro Ito
    • Organizer
      The 66th annual meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam2017

    • Author(s)
      Kosuke Soda, Nguyen Le Khanh Hang, Ung Thi Hong Trang, Hiroshi Ito, Le Thi Quynh Mai, Toshihiro Ito
    • Organizer
      International Symposium in Veterinary Science Strengthening the Collaboration between Indonesia and Japanese Veterinary School
    • Place of Presentation
      Bogor, Indonesia
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ベトナムの家禽から分離されたH3亜型インフルエンザウイルスの遺伝子と抗原性の解析2017

    • Author(s)
      柏原美奈、曽田公輔、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、高桑弘樹、Le Quynh Mai、伊藤壽啓
    • Organizer
      第32回中国四国ウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam2017

    • Author(s)
      Kosuke Soda, Ung Thi Hong Trang, Nguyen Le Khanh Hang, Tatsufumi Usui, Hiroshi Ito, Hiroichi Ozaki, Tsuyoshi Yamaguchi, Le The Quynh Mai, Toshihiro Ito
    • Organizer
      International Union of Microbiological Societies Congresses 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 2016-17シーズンに国内の野鳥糞便および斃死体から分離されたH5N6亜型高病原性鳥インフルエンザウイルスの性状解析2017

    • Author(s)
      曽田公輔、伊藤啓史、笛吹達史、尾崎弘一、村瀬敏之、山口剛士
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ベトナムの家禽から分離されたH3亜型インフルエンザウイルスの遺伝子と抗原性の解析2017

    • Author(s)
      柏原美奈、曽田公輔、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、高桑弘樹、Le Quynh Mai、伊藤壽啓
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and zoo animals in Japan in 2016-172017

    • Author(s)
      Kosuke Soda, Tatsufumi Usui, Hiroshi Ito, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Toshihiro Ito
    • Organizer
      The 65th annual meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] Serological Surveillance of Highly Pathogenic Avian Influenza in Domestic Poultry in Vietnam2016

    • Author(s)
      Nozomi Nakamura, ○Kosuke Soda, Ung Hong Trang, Nguyen Le Khanh Hang, Hiroshi Ito, Le Thi Quynh Mai, Toshihiro Ito
    • Organizer
      The 64th annual meeting of the Japanese Society for Virology
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] ベトナムの家禽におけるH5亜型高病原性鳥インフルエンザウイルス流行株の変化2016

    • Author(s)
      曽田公輔、Ung Thi Hong Trang、Le Khanh Hang Nguyen、伊藤啓史、Le The Quynh Mai、伊藤壽啓
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      神奈川県藤沢市
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ベトナムの家禽のH5亜型高病原性鳥インフルエンザウイルス(HPAIV)に対する抗体保有状況2016

    • Author(s)
      仲村 望、曽田公輔、Ung Thi Hong Trang、Le Khanh Hang Nguyen、伊藤啓史、Le The Quynh Mai、伊藤壽啓
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      神奈川県藤沢市
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam2016

    • Author(s)
      Kosuke Soda, Ung Thi Hong Trang, Kozue Hotta, Le Thi Quynh Mai, Tetsu Yamashiro, Toshihiro Ito
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      Chicago, U.S.
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antigenic and Genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses2015

    • Author(s)
      Kosuke Soda, Kozue Hotta, Ung Hong Trang, Susumu Toyoumi, Yukiko Uno, Yasuko Nagai, Tatsufumi Usui, Le Quynh Mai, Yukiko Tomioka, Hiroshi Ito, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Tetsu Yamashiro, Toshihiro Ito
    • Organizer
      The 63rd annual meeting of the Japanese Society for Virology
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ベトナムのアヒルから新たに分離されたclade2.3.4.4 H5亜型高病原性鳥インフルエンザウイルスの遺伝子と抗原性2015

    • Author(s)
      曽田公輔、Ung Hong Trang、堀田こずえ、豐海 晋、宇野有紀子、永井泰子、Le Quynh Mai、富岡幸子、尾崎弘一、伊藤啓史、山城 哲、伊藤壽啓
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      十和田、青森
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Antigenic and genetic variation of H5 highly pathogenic avian influenza viruses in domestic ducks in Vietnam2015

    • Author(s)
      Kosuke Soda, Kozue Hotta, Ung T. H. Trang, Susumu Toyoumi, Yukiko Uno, Yasuko Nagai, Tatsufumi Usui, Le T.Q. Mai, Hiroichi Ozaki, Hiroshi Ito, Hiroki Takakuwa, Toshiyuki Murase, Tsuyoshi Yamaguchi, Etsuro Ono, Koichi Otsuki, Tetsu Yamashiro, Toshihiro Ito
    • Organizer
      16th Negative Strand Virus Meeting
    • Place of Presentation
      Siena, Italy
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-02-22  

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