| Project/Area Number |
15K21210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
Synthetic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Torikai Kohei 九州大学, 理学研究院, 助教 (20456990)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 保護基 / ナフチルメトキシメチル基 / 選択的除去 / NAPOM基 / BOM系保護基 / 加水素分解 / 1-NAP基 / 1-NAPOM基 / 酸化的除去 |
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| Outline of Final Research Achievements |
In this work, "1-NAPOM" and "2-NAPOM" groups were developed as protecting groups, that work in the field of organic chemistry to suppress the reactivity of alcohols and thiols, and which can be cleaved in necessity. NAPOM groups are superior to the conventional members of benzyl and benzyloxymethyl families in that; i) it is orthogonally cleavable in the presence of benzyl and benzyloxymethyl groups; ii)it is removable in mild conditions (mildly basic, room temperature); and iii) NAPOMCl, an introducing reagent of NAPOM groups, is a stable and isolable solid, which can be stored and therefore be commerciallized.
Besides, it was revealed that these protecting groups can be applicable to the glyco- and peptide-chemistry. Therefore, NAPOM groups are expected to be useful tools in the field of organic chemistry, in the near future.
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