| Project/Area Number |
15K21213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
Orthopaedic surgery
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| Research Institution | Nagoya University (2016)
Kyushu University (2015) |
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Principal Investigator |
Omata Seiji 名古屋大学, 工学研究科, 特任助教 (60624814)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 再生組織工学 / 骨軟骨組織 / 最良設計 / アガロースゲル / 力学的刺激 / メカノバイオロジー / 細胞外基質 / 軟骨組織 / 骨組織 / 力学的組織誘導 |
|---|
| Outline of Final Research Achievements |
I have been developing a regenerated cartilage tissue for repairing defective/damaged articular cartilage. However, even if soft regenerated cartilage tissue like jelly was transplanted to a defective part, such as osteoarthritis, it was hard to fix and there was a problem that it was easy to detach. In this study, I aimed to construct an osteochondral tissue graft by laminating bone filling agent under a regenerated cartilage tissue. As a regenerated osteochondral tissue model, agarose gel was used for cartilage tissue, and calcium phosphate, a derivative of hydroxyapatite, was dispersed in a diluted agarose gel in a regenerated bone tissue model. We succeeded in constructing a regenerated osteochondral tissue model by suspending chondrocytes and mesenchymal stem cells for each tissue model. Basic experiments have completed, and from now on we will verify design method and effectiveness.
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