Invention of suitable design method for regenerated osteochondral tissue under mechanical loading
| Project/Area Number |
15K21213
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
Orthopaedic surgery
|
|---|
| Research Institution | Nagoya University (2016)
Kyushu University (2015) |
|---|
Principal Investigator |
Omata Seiji 名古屋大学, 工学研究科, 特任助教 (60624814)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 再生組織工学 / 骨軟骨組織 / 最良設計 / アガロースゲル / 力学的刺激 / メカノバイオロジー / 細胞外基質 / 軟骨組織 / 骨組織 / 力学的組織誘導 |
|---|
| Outline of Final Research Achievements |
I have been developing a regenerated cartilage tissue for repairing defective/damaged articular cartilage. However, even if soft regenerated cartilage tissue like jelly was transplanted to a defective part, such as osteoarthritis, it was hard to fix and there was a problem that it was easy to detach. In this study, I aimed to construct an osteochondral tissue graft by laminating bone filling agent under a regenerated cartilage tissue. As a regenerated osteochondral tissue model, agarose gel was used for cartilage tissue, and calcium phosphate, a derivative of hydroxyapatite, was dispersed in a diluted agarose gel in a regenerated bone tissue model. We succeeded in constructing a regenerated osteochondral tissue model by suspending chondrocytes and mesenchymal stem cells for each tissue model. Basic experiments have completed, and from now on we will verify design method and effectiveness.
|
Report
(3 results)
Research Products
(22 results)
-
-
[Presentation] バイオニックアイを用いた内境界膜剥離手術トレーニングシステム2017
Author(s)
染矢雄成, 小俣誠二, 早川健, 光石衛, 杉田直彦, 原田香奈子, 野田康雄, 上田高志, 戸塚清人, 荒木章之, 相原一, 新井史人
Organizer
第25回日本コンピュータ外科学会大会
Place of Presentation
東京都大田区
Year and Date
2017-11-26
Related Report
-
-
[Presentation] Bionic eye model for retinal surgery training2017
Author(s)
小俣誠二, 染矢雄成, 足達俊哉, 早川健, 原田香奈子, 光石衛, 戸塚清人, 荒木章之, 高尾宗之, 相原一, 新井史人
Organizer
第５回バイオメカニクス研究センター＆エレクトロニクス実装学会九州支部合同研究会
Place of Presentation
福岡県福岡市
Related Report
Invited
-
-
[Presentation] Training System Using Bionic-eye for Internal Limiting Membrane Peeling2016
Author(s)
Y. Someya, S. Omata, T. Hayakawa, M. Mitsuishi, N. Sugita, K. Harada, Y. Noda, T. Ueta, K. Totsuka, F. Araki, H. Aihara, F. Arai
Organizer
27th 2016 International Symposium on Micro-Nano Mechatronics and Human Science
Place of Presentation
Nagoya University, Nagoya, Japan
Year and Date
2016-11-28
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
[Presentation] Development of artificial hydrogel cartilage with superior lubricity based on bionic design2015
Author(s)
T. Murakami, S, Yarimitsu, K Nakashima, N Sakai, T Yamaguchi, S. Omata, S, Sasaki, Y. Sawae, A, Suzuki.
Organizer
International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
Place of Presentation
Fukuoka, Japan
Year and Date
2015-12-09
Related Report
-
-
-
-
-
-
-
-
-
