Associations between obesity, abnormal glucose/lipid metabolism, and clinico-biological factors in patients with breast cancer

• Project/Area Number: 15K21239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery; Metabolomics
• Research Institution: National Cancer Center Japan
• Principal Investigator: Hayashi Mitsuhiro 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 (50735628)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 乳癌 / 肥満 / 腫瘍硬度 / Elastography / 脂質 / BMI / 脂質代謝 / elastography

Outline of Final Research Achievements

In this study, we investigated the relationship between obesity, abnormal glucose/lipid metabolism, and clinicopathological factors in patients with breast cancer. In postmenopausal estrogen receptor-positive breast cancer, there were many cases with high body mass index. Furthermore, obesity was involved in the tumor stiffness of breast cancer by elastographic evaluation, and tumor stiffness significantly correlated with lymph node metastasis and high gene expression of lysyl oxidase. In vitro/vivo experiments suggested that lipid pathway contributed to the behavior of breast cancer.

Research Products

• [Journal Article] Successful ethinylestradio therapy for a metastatic breast cancer patient with heavily pre-treated with endocrine therapies. (2016)
  • Author(s): Sueta A, Hayashi M, Fukugawa Y, Shimizu H, Yamamoto-Ibusuki M, Yamamoto Y, Iwase H.
  • Journal Title: Int Can Conf J. Volume: 5 Issue: 3 Pages: 126-126
  • DOI: 10.1007/s13691-015-0241-7
  • Peer Reviewed
• [Journal Article] Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging. (2016)
  • Author(s): Aikawa H, Hayashi M, Ryu A, Yamashita M, Ohtsuka N, Nishidate M, Fujiwara Y, Hamada A.
  • Journal Title: Sci Rep Volume: 30 Issue: 1 Pages: 23749-23749
  • DOI: 10.1038/srep23749
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer. (2016)
  • Author(s): 2.Tomiguchi M, Yamamoto Y, Yamamoto-Ibusuki M, Goto-Yamaguchi L, Fujiki Y, Fujiwara S, Sueta A, Hayashi M, Takeshita T, Inao T, Iwase H.
  • Journal Title: Cancer Sci. Volume: 107(4) Issue: 4 Pages: 491-8
  • DOI: 10.1111/cas.12897
  • Peer Reviewed
• [Journal Article] Associations between elastography findings and clinicopathological factors in breast cancer. (2015)
  • Author(s): Hayashi M, Yamamoto Y, Sueta A, Tomiguchi M, Yamamoto-Ibusuki M, Kawasoe T, Hamada A, Iwase H.
  • Journal Title: Medicine (Baltimore) Volume: 94 Issue: 50 Pages: e2290-e2290
  • DOI: 10.1097/md.0000000000002290
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 術前化学療法開始前のElastography FLR評価と治療効果との関係 (2016)
  • Author(s): 林 光博、岩瀬 弘敬
  • Organizer: 日本超音波医学会第89回学術集会
  • Place of Presentation: 国立京都国際会館、京都市、京都
  • Year and Date: 2016-05-29
  • Invited
• [Presentation] Correlations between elastographic evaluations and clinicopathological factors in breast cancer (2016)
  • Author(s): Mitsuhiro Hayashi, Hirotaka Iwase
  • Organizer: 日本超音波医学会第89回学術集会
  • Place of Presentation: 国立京都国際会館、京都市、京都
  • Year and Date: 2016-05-28
  • Int'l Joint Research / Invited
• [Presentation] 乳癌硬度評価と臨床病理学的因子に関する検討、特にリンパ節転移との関係について (2015)
  • Author(s): 林 光博、冨口 麻衣、末田 愛子、藤原 沙織、山本 聡子、竹下 卓志、稲尾 瞳子、指宿 睦子、村上 敬一、山本 豊、岩瀬 弘敬
  • Organizer: 第23回日本乳癌学会学術総会
  • Place of Presentation: 東京国際フォーラム、千代田区、東京都
  • Year and Date: 2015-07-02