The discovery of a new predictor of aortic aneurysm rupture

Research Project

Project/Area Number	15K21244
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular surgery Cardiovascular medicine
Research Institution	Kumamoto University
Principal Investigator	Tazume Hirokazu 熊本大学, 大学院生命科学研究部(医), 助教 (10648273)
Co-Investigator(Renkei-kenkyūsha)	Oike Yuichi 熊本大学, 大学院・生命科学研究部・分子遺伝学分野, 教授 (90312321) Miyata Keishi 熊本大学, 大学院・生命科学研究部・免疫アレルギー血管病態学寄附講座, 特任准教授 (50398228) Tian Zhe 熊本大学, 大学院・生命科学研究部・分子遺伝学分野, 研究員 (80723890) Fukui Toshihiro 熊本大学, 大学院・生命科学研究部・心臓血管外科学, 教授 (50445045) Kawasuji Michio 熊本大学, 大学院・生命科学研究部・心臓血管外科学, 前教授 (40135067)
Research Collaborator	Horio Eiji
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	大動脈瘤 / 慢性炎症
Outline of Final Research Achievements	Molecular mechanism in the development of AAA has not been elucidated well. Clinical studies indicate a significant association between cigarette smoking and aortic aneurysm development, and that the duration of time smoked parallels elevated AAA risk. Our studies demonstrate that nicotine accelerates AAA progression by altering expression levels of Angptl2 and MMP-9 activity in the aneurysmal vessel wall. And some microRNAs related to inflammation were also upregulated in the aneurysmal vessel wall. Angptl2 is a potential target for use in novel prevention and treatment strategies against AAA.