Elucidation of regulatory mechanism of capacitation by extracellular Na+ in hamster spermatozoa
| Project/Area Number |
15K21323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
Urology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Takei Gen 獨協医科大学, 医学部, 助教 (00708183)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 哺乳類精子 / 受精能獲得 / 超活性化 / Na+ / Na/K ATPase / Na-Ca Exchanger / Na Ca Exchanger / 鞭毛運動 / Na+/Ca2+ exchanger / Na+/K+ ATPase / NCX / NKA |
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| Outline of Final Research Achievements |
In my previous study, I revealed oviductal fluid contains high concentration of Na+ compared to the medium for the in vitro fertilization in hamsters. Based on the previous study, present study was performed to elucidate the impact of extracellular Na+ on hamster sperm capacitation. The result showed that hyperactivation is regulated by extracellular Na+ in hamster spermatozoa, and the activity of molecules that regulate cellular Na+ homeostasis, such as Na-Ca exchanger or Na/K ATPase, are involved in hamster sperm hyperactivation.
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Report
(4 results)
Research Products
(18 results)
