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Clinical application of Optical Coherence Tomograph with long and wide wavelength broadband as light source and elucidation of glaucoma structural change

Research Project

Project/Area Number 15K21335
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Biomedical engineering/Biomaterial science and engineering
Research InstitutionSaitama Medical University

Principal Investigator

Shoji Takuhei  埼玉医科大学, 医学部, 講師 (70637058)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords緑内障 / 光干渉断層計 / OCT / 長波長 / 広帯域 / 光源開発
Outline of Final Research Achievements

Optical coherence tomography (OCT) is a widely used instrument in ophthalmic field. As glaucoma is a chronic progressive disease, longitudinal studies, as well as cross-sectional studies, evaluating changes over time are important.
Since the Fostering Joint International Research was adopted in 2017, I went to the United States to develop this research subject and collaborated with the University of California, San Diego. Particularly since the institution is a pioneer in clinical application of optical coherence tomography angiography (OCTA) in the world, I was able to do many papers and academic presentations related to this field.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (9 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (27 results) (of which Int'l Joint Research: 14 results,  Invited: 5 results)

  • [Int'l Joint Research] University of California, San Diego(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Hamilton Glaucoma Center(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes2018

    • Author(s)
      Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 190 Pages: 69-77

    • DOI

      10.1016/j.ajo.2018.03.026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macular Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects2018

    • Author(s)
      Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Suh Min Hee、Shoji Takuhei、Hasenstab Kyle A.、Saunders Luke J.、Moghimi Sasan、Hou Huiyuan、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
    • Journal Title

      Journal of Glaucoma

      Volume: 27 Issue: 4 Pages: 342-349

    • DOI

      10.1097/ijg.0000000000000922

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients2018

    • Author(s)
      Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN
    • Journal Title

      Am J Ophthalmol

      Volume: 189 Pages: 1-9

    • DOI

      10.1016/j.ajo.2018.02.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes2018

    • Author(s)
      Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN
    • Journal Title

      J Glaucoma

      Volume: 27 Issue: 3 Pages: 227-232

    • DOI

      10.1097/ijg.0000000000000862

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo crystalline lens measurements with novel swept-source optical coherent tomography: an investigation on variability of measurement.2017

    • Author(s)
      Shoji T, Kato N, Ishikawa S, Ibuki H, Yamada N, Kimura I, Shinoda K
    • Journal Title

      BMJ Open Ophthalmology

      Volume: 1 Issue: 1 Pages: e000058-e000058

    • DOI

      10.1136/bmjophth-2016-000058

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes2017

    • Author(s)
      Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN
    • Journal Title

      J Glaucoma

      Volume: 26 Issue: 10 Pages: 851-859

    • DOI

      10.1097/ijg.0000000000000768

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glaucomatous changes in lamina pores shape within the lamina cribrosa using wide bandwidth, femtosecond mode-locked laser OCT2017

    • Author(s)
      Shoji Takuhei、Kuroda Hiroto、Suzuki Masayuki、Ibuki Hisashi、Araie Makoto、Yoneya Shin
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0181675-e0181675

    • DOI

      10.1371/journal.pone.0181675

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study2017

    • Author(s)
      Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN
    • Journal Title

      Am J Ophthalmol

      Volume: 182 Pages: 107-117

    • DOI

      10.1016/j.ajo.2017.07.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vertical asymmetry of lamina cribrosa tilt angles using wide bandwidth, femtosecond mode-locked laser OCT; effect of myopia and glaucoma.2017

    • Author(s)
      Shoji T, Kuroda H, Suzuki M, Ibuki H, Araie M, Yoneya S.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 255 Issue: 1 Pages: 197-205

    • DOI

      10.1007/s00417-016-3524-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The African Descent and Glaucouma Evaluation Study : Racial Difference in the Rate of Retinal Nerve Fiber Layer Thinning in Eyes Suspected of Glaucouma : 5-Year Follow-Up2018

    • Author(s)
      Takuhei Shoji ,Tadamishi AKAGI, Luke J.SAUNDERS, Robert N.WEINREB, Linda M.ZANGWILL
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evalution of the Repeatability of Peripapillary Vascular Density With Swept-Source Optical Coherence Tomography Angiography2018

    • Author(s)
      Yuji Yoshikawa ,Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative Assessment of Blood Vessel Density in Prelaminar Area With Swept-Source Optical Coherence Tomography Angiography in Healthy Subjects2018

    • Author(s)
      Kimitake Ozaki, Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI, Yuji Yoshikawa
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The rate of macular microvascular dropout is faster in glaucoma eyes than glaucoma suspect and healthy eyes: a longitudinal study2017

    • Author(s)
      Shoji T, Zangwill L, Akagi T, Saunders L, Yarmohammadi A, Manalastas PI, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
    • Place of Presentation
      米国、ボルチモア
    • Year and Date
      2017-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes2017

    • Author(s)
      Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
    • Place of Presentation
      米国、ボルチモア
    • Year and Date
      2017-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage2017

    • Author(s)
      Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
    • Place of Presentation
      米国、ボルチモア
    • Year and Date
      2017-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes2017

    • Author(s)
      Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
    • Place of Presentation
      米国、ボルチモア
    • Year and Date
      2017-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] OCTによる緑内障の観察アップデート2017

    • Author(s)
      庄司拓平
    • Organizer
      第121回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma2017

    • Author(s)
      Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
    • Organizer
      American Academy of Ophthalmology (AAO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 緑内障眼の乳頭出血発症時期の違いと網膜神経線維層菲薄化速度の関係2017

    • Author(s)
      赤木忠道、Robert N.Weinreb、庄司拓平、辻川孝明
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スウェプトソース光干渉断層アンギオグラフィーによる黄斑部網膜血管密度の定量化2017

    • Author(s)
      石井宏和、庄司拓平、吉川祐司、菅野順二、伊吹寿士、尾﨑公威、長島崇充、市川良和、兒玉章宏、勝本武志、渋谷雅之、山田教弘、木村至、篠田啓
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comparison of structure and VD in POAG with parafoveal scotoma and nasal step2017

    • Author(s)
      庄司拓平、Luke J Saunders、赤木忠道、篠田啓、Linda M Zangwill、Robert N.Weinreb
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スウェプトソース光干渉断層計アンギオグラフィ―による乳頭内血管密度の検討2017

    • Author(s)
      尾﨑公威、吉川祐司、庄司拓平、菅野順二、伊吹寿士、石井宏和、秋山淳、木村至、篠田啓
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スウェプトソース光干渉断層アンギオグラフィーによる視神経乳頭周囲網膜血管密度の検討2017

    • Author(s)
      吉川祐司、庄司拓平、菅野順二、伊吹寿士、尾﨑公威、石井宏和、秋山淳、木村至、篠田啓
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Macular Vessel Density Loss is Increased in Primary Open Angle Glaucoma: A Longitudinal Study2017

    • Author(s)
      庄司拓平、Luke J Saunders, 赤木忠道、篠田啓、Linda M Zangeill, Robert N Wienreb
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Myopia and Glaucoma; Distortion of Lamina Cribrosa2017

    • Author(s)
      Takuhei Shoji
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The rate of macular microvascular dropout is faster in glaucoma eyes than glaucoma suspect and healthy eyes: a longitudinal study2017

    • Author(s)
      Shoji T, Zangwill L, Akagi T, Saunders L, Yarmohammadi A, Manalastas PI, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes2017

    • Author(s)
      Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage2017

    • Author(s)
      Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes2017

    • Author(s)
      Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ellipsoid zone thickness measurements by high resolution mode-locked laser optical coherence tomography in healthy eyes2017

    • Author(s)
      Itaru Kimura, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Takuhei Shoji, Kei Shinoda, Makoto Araie, Shin Yoneya
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 緑内障のOCT: これまでの基本、これからの応用」「OCTによる緑内障の観察アップデート2017

    • Author(s)
      庄司拓平
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] モードロックOCT2016

    • Author(s)
      庄司拓平
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-19
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Changes in the structure of lamina pores within the lamina cribrosa using wide bandwidth, femtosecond modelocked2016

    • Author(s)
      Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Makoto Araie, Shin Yoneya
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2016 Annual Meeting, Seattle
    • Place of Presentation
      The Washington State Convention Center (アメリカ、シアトル)
    • Year and Date
      2016-05-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 篩状板孔形状と緑内障および篩状板深度・位置の関連2016

    • Author(s)
      庄司拓平、黒田寛人、鈴木将之、伊吹寿士、木村至、新家眞、米谷新
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 広帯域モード・ロックOCT を用いた篩状板傾斜角と緑内障・近視の関連2016

    • Author(s)
      庄司拓平
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-07
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 進行緑内障眼における篩状板孔形状と篩状板深度・位置の関連2015

    • Author(s)
      庄司拓平、黒田寛人、鈴木将之、伊吹寿士、木村至、新家眞、米谷新
    • Organizer
      第26回日本緑内障学会
    • Place of Presentation
      ウインク愛知(愛知県名古屋市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-06-07  

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