Clinical application of Optical Coherence Tomograph with long and wide wavelength broadband as light source and elucidation of glaucoma structural change

• Project/Area Number: 15K21335
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Saitama Medical University
• Principal Investigator: Shoji Takuhei 埼玉医科大学, 医学部, 講師 (70637058)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 緑内障 / 光干渉断層計 / OCT / 長波長 / 広帯域 / 光源開発

Outline of Final Research Achievements

Optical coherence tomography (OCT) is a widely used instrument in ophthalmic field. As glaucoma is a chronic progressive disease, longitudinal studies, as well as cross-sectional studies, evaluating changes over time are important.
Since the Fostering Joint International Research was adopted in 2017, I went to the United States to develop this research subject and collaborated with the University of California, San Diego. Particularly since the institution is a pioneer in clinical application of optical coherence tomography angiography (OCTA) in the world, I was able to do many papers and academic presentations related to this field.

Research Products

• [Int'l Joint Research] University of California, San Diego(米国)
• [Int'l Joint Research] Hamilton Glaucoma Center(米国)
• [Journal Article] Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes (2018)
  • Author(s): Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 190 Pages: 69-77
  • DOI: 10.1016/j.ajo.2018.03.026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Macular Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects (2018)
  • Author(s): Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Suh Min Hee、Shoji Takuhei、Hasenstab Kyle A.、Saunders Luke J.、Moghimi Sasan、Hou Huiyuan、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: Journal of Glaucoma Volume: 27 Issue: 4 Pages: 342-349
  • DOI: 10.1097/ijg.0000000000000922
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients (2018)
  • Author(s): Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN
  • Journal Title: Am J Ophthalmol Volume: 189 Pages: 1-9
  • DOI: 10.1016/j.ajo.2018.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes (2018)
  • Author(s): Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN
  • Journal Title: J Glaucoma Volume: 27 Issue: 3 Pages: 227-232
  • DOI: 10.1097/ijg.0000000000000862
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] In vivo crystalline lens measurements with novel swept-source optical coherent tomography: an investigation on variability of measurement. (2017)
  • Author(s): Shoji T, Kato N, Ishikawa S, Ibuki H, Yamada N, Kimura I, Shinoda K
  • Journal Title: BMJ Open Ophthalmology Volume: 1 Issue: 1 Pages: e000058-e000058
  • DOI: 10.1136/bmjophth-2016-000058
  • Peer Reviewed / Open Access
• [Journal Article] Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes (2017)
  • Author(s): Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN
  • Journal Title: J Glaucoma Volume: 26 Issue: 10 Pages: 851-859
  • DOI: 10.1097/ijg.0000000000000768
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glaucomatous changes in lamina pores shape within the lamina cribrosa using wide bandwidth, femtosecond mode-locked laser OCT (2017)
  • Author(s): Shoji Takuhei、Kuroda Hiroto、Suzuki Masayuki、Ibuki Hisashi、Araie Makoto、Yoneya Shin
  • Journal Title: PLOS ONE Volume: 12 Issue: 7 Pages: e0181675-e0181675
  • DOI: 10.1371/journal.pone.0181675
  • Peer Reviewed / Open Access
• [Journal Article] Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study (2017)
  • Author(s): Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN
  • Journal Title: Am J Ophthalmol Volume: 182 Pages: 107-117
  • DOI: 10.1016/j.ajo.2017.07.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vertical asymmetry of lamina cribrosa tilt angles using wide bandwidth, femtosecond mode-locked laser OCT; effect of myopia and glaucoma. (2017)
  • Author(s): Shoji T, Kuroda H, Suzuki M, Ibuki H, Araie M, Yoneya S.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 255 Issue: 1 Pages: 197-205
  • DOI: 10.1007/s00417-016-3524-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The African Descent and Glaucouma Evaluation Study : Racial Difference in the Rate of Retinal Nerve Fiber Layer Thinning in Eyes Suspected of Glaucouma : 5-Year Follow-Up (2018)
  • Author(s): Takuhei Shoji ,Tadamishi AKAGI, Luke J.SAUNDERS, Robert N.WEINREB, Linda M.ZANGWILL
  • Organizer: 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
  • Int'l Joint Research
• [Presentation] Evalution of the Repeatability of Peripapillary Vascular Density With Swept-Source Optical Coherence Tomography Angiography (2018)
  • Author(s): Yuji Yoshikawa ,Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI
  • Organizer: 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
  • Int'l Joint Research
• [Presentation] Quantitative Assessment of Blood Vessel Density in Prelaminar Area With Swept-Source Optical Coherence Tomography Angiography in Healthy Subjects (2018)
  • Author(s): Kimitake Ozaki, Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI, Yuji Yoshikawa
  • Organizer: 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
  • Int'l Joint Research
• [Presentation] The rate of macular microvascular dropout is faster in glaucoma eyes than glaucoma suspect and healthy eyes: a longitudinal study (2017)
  • Author(s): Shoji T, Zangwill L, Akagi T, Saunders L, Yarmohammadi A, Manalastas PI, Penteado R, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
  • Place of Presentation: 米国、ボルチモア
  • Year and Date: 2017-05-07
  • Int'l Joint Research
• [Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes (2017)
  • Author(s): Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
  • Place of Presentation: 米国、ボルチモア
  • Year and Date: 2017-05-07
  • Int'l Joint Research
• [Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage (2017)
  • Author(s): Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
  • Place of Presentation: 米国、ボルチモア
  • Year and Date: 2017-05-07
  • Int'l Joint Research
• [Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes (2017)
  • Author(s): Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting
  • Place of Presentation: 米国、ボルチモア
  • Year and Date: 2017-05-07
  • Int'l Joint Research
• [Presentation] OCTによる緑内障の観察アップデート (2017)
  • Author(s): 庄司拓平
  • Organizer: 第121回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2017-04-06
  • Invited
• [Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma (2017)
  • Author(s): Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
  • Organizer: American Academy of Ophthalmology (AAO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] 緑内障眼の乳頭出血発症時期の違いと網膜神経線維層菲薄化速度の関係 (2017)
  • Author(s): 赤木忠道、Robert N.Weinreb、庄司拓平、辻川孝明
  • Organizer: 第71回日本臨床眼科学会
• [Presentation] スウェプトソース光干渉断層アンギオグラフィーによる黄斑部網膜血管密度の定量化 (2017)
  • Author(s): 石井宏和、庄司拓平、吉川祐司、菅野順二、伊吹寿士、尾﨑公威、長島崇充、市川良和、兒玉章宏、勝本武志、渋谷雅之、山田教弘、木村至、篠田啓
  • Organizer: 第71回日本臨床眼科学会
• [Presentation] Comparison of structure and VD in POAG with parafoveal scotoma and nasal step (2017)
  • Author(s): 庄司拓平、Luke J Saunders、赤木忠道、篠田啓、Linda M Zangwill、Robert N.Weinreb
  • Organizer: 第71回日本臨床眼科学会
• [Presentation] スウェプトソース光干渉断層計アンギオグラフィ―による乳頭内血管密度の検討 (2017)
  • Author(s): 尾﨑公威、吉川祐司、庄司拓平、菅野順二、伊吹寿士、石井宏和、秋山淳、木村至、篠田啓
  • Organizer: 第28回日本緑内障学会
• [Presentation] スウェプトソース光干渉断層アンギオグラフィーによる視神経乳頭周囲網膜血管密度の検討 (2017)
  • Author(s): 吉川祐司、庄司拓平、菅野順二、伊吹寿士、尾﨑公威、石井宏和、秋山淳、木村至、篠田啓
  • Organizer: 第28回日本緑内障学会
• [Presentation] Macular Vessel Density Loss is Increased in Primary Open Angle Glaucoma: A Longitudinal Study (2017)
  • Author(s): 庄司拓平、Luke J Saunders, 赤木忠道、篠田啓、Linda M Zangeill, Robert N Wienreb
  • Organizer: 第28回日本緑内障学会
• [Presentation] Myopia and Glaucoma; Distortion of Lamina Cribrosa (2017)
  • Author(s): Takuhei Shoji
  • Organizer: 第28回日本緑内障学会
  • Invited
• [Presentation] The rate of macular microvascular dropout is faster in glaucoma eyes than glaucoma suspect and healthy eyes: a longitudinal study (2017)
  • Author(s): Shoji T, Zangwill L, Akagi T, Saunders L, Yarmohammadi A, Manalastas PI, Penteado R, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes (2017)
  • Author(s): Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage (2017)
  • Author(s): Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes (2017)
  • Author(s): Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] Ellipsoid zone thickness measurements by high resolution mode-locked laser optical coherence tomography in healthy eyes (2017)
  • Author(s): Itaru Kimura, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Takuhei Shoji, Kei Shinoda, Makoto Araie, Shin Yoneya
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
  • Int'l Joint Research
• [Presentation] 緑内障のOCT: これまでの基本、これからの応用」「OCTによる緑内障の観察アップデート (2017)
  • Author(s): 庄司拓平
  • Organizer: 第121回日本眼科学会総会
  • Invited
• [Presentation] モードロックOCT (2016)
  • Author(s): 庄司拓平
  • Organizer: 第27回日本緑内障学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-19
  • Invited
• [Presentation] Changes in the structure of lamina pores within the lamina cribrosa using wide bandwidth, femtosecond modelocked (2016)
  • Author(s): Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Makoto Araie, Shin Yoneya
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2016 Annual Meeting, Seattle
  • Place of Presentation: The Washington State Convention Center (アメリカ、シアトル)
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] 篩状板孔形状と緑内障および篩状板深度・位置の関連 (2016)
  • Author(s): 庄司拓平、黒田寛人、鈴木将之、伊吹寿士、木村至、新家眞、米谷新
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-04-07
• [Presentation] 広帯域モード・ロックOCT を用いた篩状板傾斜角と緑内障・近視の関連 (2016)
  • Author(s): 庄司拓平
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-04-07
  • Invited
• [Presentation] 進行緑内障眼における篩状板孔形状と篩状板深度・位置の関連 (2015)
  • Author(s): 庄司拓平、黒田寛人、鈴木将之、伊吹寿士、木村至、新家眞、米谷新
  • Organizer: 第26回日本緑内障学会
  • Place of Presentation: ウインク愛知（愛知県名古屋市）
  • Year and Date: 2015-09-11