Elucidation of biological properties and acquisition of tumor-specific marker for micropapillary predominant lung adenocarcinoma
Project/Area Number |
15K21359
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
Tumor diagnostics
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Research Institution | Kitasato University |
Principal Investigator |
Nagashio Ryo 北里大学, 医療衛生学部, 講師 (40618568)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 肺腺癌 / 微小乳頭肺腺癌 / プロテオミクス / 癌幹細胞 / NAP1L1 / 診断マーカー / 鑑別診断マーカー / 浸潤 / 転移 / 浸潤・転移 |
Outline of Final Research Achievements |
To elucidate the biological properties of lung micropapillary predominant adenocarcinoma (MPPAC) and to acquisition of differential bio-marker for lung AC, we performed proteome analysis using MPPAC-4F cells established as cancer stem cell-like cell. Of the identified proteins, we focused on NAP1L1. To evaluate the diagnostic utility of NAP1L1 in lung cancer, immunohistochemistry was performed using lung cancer tissues. As a result, NAP1L1 expression in AC significantly correlated with poorer differentiation, tumor size, higher pathological stage, N factor, lymphatic invasion, vascular invasion, and poorer prognosis of AC patients. Furthermore, multivariate analysis confirmed that NAP1L1 expression increased the hazard of death after adjusting for the other clinicopathological factors. These findings suggest that NAP1L1 expression seems to be an independent and significant predictor of poorer survival of AC patients.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer2017
Author(s)
Minami Sho, Matsumoto Kazumasa, Nagashio Ryo, Hagiuda Daisuke, Fukuda Eriko, Goshima Naoki, Hattori Manabu, Tsuchiya Benio, Hachimura Kazuo, Jiang Shi-Xu, Saegusa Makoto, Iwamura Masatsugu, Sato Yuichi
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Journal Title
Anticancer Research
Volume: 37
Pages: 6705-6714
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of nestin expression in patients with resected non-small cell lung cancer treated with platinum-based adjuvant chemotherapy; relationship between nestin expression and epithelial to mesenchymal transition related markers.2017
Author(s)
Ryuge S, Sato Y, Nagashio R, Hiyoshi Y, Katono K, Igawa S, Nakashima H, Shiomi K, Ichinoe M, Murakumo Y, Saegusa M, Satoh Y, Masuda N
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Journal Title
PLoS One
Volume: 12
Issue: 3
Pages: e0173886-e0173886
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of PD-L1 Expression in Patients with Surgically Resected Non-Small-Cell Lung Cancer.2017
Author(s)
Igawa S, Sato Y, Ryuge S, Ichinoe M, Katono K, Hiyoshi Y, Otani S, Nagashio R, Nakashima H, Katagiri M, Sasaki J, Murakumo Y, Satoh Y, Masuda N
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Journal Title
Oncology
Volume: 92
Issue: 5
Pages: 283-290
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases.2016
Author(s)
Kuji S, Watanabe R, Sato Y, Iwata T, Hirashima Y, Takekuma M, Ito I, Abe M, Nagashio R, Omae K, Aoki D, Kameya T
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Journal Title
Gynecol Oncol
Volume: 144
Issue: 2
Pages: 384-390
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum anti-Gal-3 autoantibody is a predictive marker of the efficacy of platinum-based chemotherapy against pulmonary adenocarcinoma2015
Author(s)
Kengo Yanagita, Ryo Nagashio, Shinichiro Ryuge, Ken Katono, Shi-Xu Jiang, Benio Tsuchiya, Hiroyasu Nakashima, Eriko Fukuda, Naoki Goshima, Makoto Saegusa, Yukitoshi Satoh, Noriyuki Masuda, Yuichi Sato
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Journal Title
Asian Pac J Cancer Prev
Volume: 16
Pages: 7959-7965
Related Report
Peer Reviewed / Open Access
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[Journal Article] S100A16 is a prognostic marker for lung adenocarcinomas2015
Author(s)
Keita Saito, Makoto Kobayashi, Ryo Nagashio, Shinichiro Ryuge, Ken Katono, Hiroyasu Nakashima, Benio Tsuchiya, Shi-Xu Jiang, Makoto Saegusa, Yukitoshi Satoh, Noriyuki Masuda, Yuichi Sato
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Journal Title
Asian Pac J Cancer Prev
Volume: 16
Pages: 7039-7044
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calnexin is a novel sero-diagnostic marker for lung cancer.2015
Author(s)
Kobayashi M, Nagashio R, Jiang S-X, Saito K, Tsuchiya B, Ryuge S, Katono K, Nakashima H, Fukuda E, Goshima N, Satoh Y, Masuda N, Saegusa M, Sato Y.
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Journal Title
Lung Cancer
Volume: 90
Issue: 2
Pages: 342-345
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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