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A novel therapeutic strategy against psoriasis by using nicotinic acetylcholine receptor modulator, SLURP-1

Research Project

Project/Area Number 15K21370
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Pharmacology in pharmacy
Research InstitutionKeio University

Principal Investigator

Moriwaki Yasuhiro  慶應義塾大学, 薬学部(芝共立), 講師 (00392150)

Research Collaborator TSUJI Shoutaro  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords乾癬 / SLURP-1 / 黄色ブドウ球菌 / 抗菌活性 / 皮膚バリア機能 / 正常ヒト表皮角化細胞 / α7ニコチン性アセチルコリン受容体 / T-reg / IL-22
Outline of Final Research Achievements

SLURP1 is the causal gene for Mal de Meleda (MDM), an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis. Recently, SLURP1-deficient mice show MDM-like symptoms such as severe palmoplantar keratoderma characterized by increased keratinocyte proliferation and water barrier defects. Although SLURP1 likely serves as an important proliferation/differentiation factor in keratinocytes, the possible relation between SLURP1 and other skin diseases, such as psoriasis and atopic dermatitis, has not been studied. In our experiment, we found SLURP1 expression is greatly increased within the skin lesions in a psoriatic mouse model. In addition, recombinant SLURP1 suppressed the growth of S. aureus, which is associated with disease severity in psoriasis. These results suggest that SLURP1 may contribute to the pathogenesis of psoriasis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma.2017

    • Author(s)
      Shoutaro Tsuji, Kota Washimi, Taihei Kageyama, Makiko Yamashita, Rieko Matsuura, Tomoyuki Yokose, Yoichi Kameda, Hiroyuki Hayashi, Takao Morohoshi, Yukio Tsuura, Toshikazu Yusa, Takashi Sato, Hisashi Narimatsu, Yasuhiro Moriwaki, Hidemi Misawa, Kenzo Hiroshima, Yohei Miyagi, and Kohzoh Imai, et al.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45768-45768

    • DOI

      10.1038/srep45768

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-kappaB activation2016

    • Author(s)
      Funakoshi-Tago M, Miyagawa Y, Ueda F, Mashino T, Moriwaki Y, Tago K, Kasahara T, Tamura H
    • Journal Title

      Int Immunopharmacol

      Volume: 40 Pages: 254-264

    • DOI

      10.1016/j.intimp.2016.08.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reappraisal of VAChT-Cre: Preference in slow motor neurons innervating type I or IIa muscle fibers2016

    • Author(s)
      Misawa H, Inomata D, Kikuchi M, Maruyama S, Moriwaki Y, Okuda T, Nukina N, Yamanaka T.
    • Journal Title

      Genesis.

      Volume: 54 Issue: 11 Pages: 568-572

    • DOI

      10.1002/dvg.22979

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9.2016

    • Author(s)
      Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, *Misawa H.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27354-27354

    • DOI

      10.1038/srep27354

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ニコチン受容体修飾因子SLURP-1による乾癬の新規治療戦略2016

    • Author(s)
      森脇康博
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 66 Pages: 45-49

    • Related Report
      2016 Annual Research Report
  • [Journal Article] IL-22/STAT3-induced increases in SLURP1 expression within psoriatic lesions exerts antimicrobial effects against Staphylococcus aureus.2015

    • Author(s)
      Moriwaki Y, Takada K, Nagasaki T, Kubo N, Ishii T, Kose K, Kageyama T, Tsuji S, Kawashima K, Misawa H
    • Journal Title

      PLoS One

      Volume: 該当なし Issue: 10 Pages: e0140750-e0140750

    • DOI

      10.1371/journal.pone.0140750

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: a special reference to the nested gene LYNX1.2015

    • Author(s)
      Moriwaki Y, Takada K, Tsuji S, Kawashima K, Misawa H
    • Journal Title

      Int immunopharmacol

      Volume: 29 Issue: 1 Pages: 71-75

    • DOI

      10.1016/j.intimp.2015.05.030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 中皮腫マーカー蛋白質, インテレクチン-1と1, 2-diolの結合様式の解析2017

    • Author(s)
      長崎俊憲, 森脇康博, 三澤日出巳, 辻祥太郎.
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎県長崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role for α7 nicotinic acetylcholine receptors in naive T cell differentiation into regulatory T cell.2016

    • Author(s)
      Kawashima K, Mashimo T, Fujii T, Moriwaki Y, Misawa H, Ono S.
    • Organizer
      46th Annual Meeting, Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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