Risk stratification of sudden cardiac death in patients with implantable cardioverter defibrillator using a high resolution electrocardiography; DREAM-ECG
Project/Area Number |
15K21388
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
Medical engineering assessment
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Suzuki Atsushi 東京女子医科大学, 医学部, 助教 (00625626)
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Research Collaborator |
SHIGA Tsuyoshi
NAKAI Kenji
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 突然死 / 心不全 / 12誘導心電図 / 心室不整脈 / 植込み型除細動器 / 心室遅延電位 / 高分解能心電図 / 心臓突然死 / 心室頻拍 / 心室細動 / 両室ペーシング機能付き植込み型除細動器 / 心筋症 |
Outline of Final Research Achievements |
This study included 125 consecutive heart failure (HF) patients received cardiac resynchronization therapy (CRT) with an indication for primary prevention of sudden cardiac death. 6 patients (5%) experienced electrical storm (ES). Patients with ES had a significantly higher Tp-e dispersion on 12-lead ECG (80±27 vs 60±37ms, p<0.05) and inter-lead difference between Tp-e intervals on 187-channel repolarization interval-difference mapping ECG (DREAM-ECG) (84±20 vs 60±23ms, p<0.05) than those without ES. Among 103 consecutive non-ischemic HF patients, 50 (49%) patients had widening filtered QRS (fQRS) between before and after CRT implantation recorded by signal averaged electrocardiograph (SAECG). There was a trend of increased occurrence of ventricular arrhythmias in patients with widening fQRS than narrowing fQRS. In HF patients received CRT, both depolarization and repolarization abnormalities may be associated with the incidence of ventricular arrhythmias after device implantation.
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling2018
Author(s)
Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 20114-20119
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Paroxysmal atrial fibrillation recurrences and quality of life in symptomatic patients: A crossover study of flecainide and pilsicainide.2017
Author(s)
Shiga T, Yoshioka K, Watanabe E, Omori H, Yagi M, Okumura Y, Matsumoto N, Kusano K, Oshiro C, Ikeda T, Takahashi N, Komatsu T, Suzuki A, Suzuki T, Sato Y, Yamashita T; AF-QOL study investigators.
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Journal Title
J Arrhythm
Volume: 33
Issue: 4
Pages: 310-317
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Isolated cardiac sarcoidosis diagnosed by electroanatomic coltage mapping-guided endomyocardial biopsy combined with magnetic resonance imaging and positron emission tomography.2016
Author(s)
Kawakatsu N, Suzuki A, Serizawa N, Suzuki T, Ejima K, Shiga T, Fukushima K, Momose M, Uto K, Shoda M, Hagiwara N
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Journal Title
J Cardiol Cases
Volume: 14
Issue: 4
Pages: 107-110
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Blood Urea Nitrogen to Albumin Ratio Predicts Mortality of Japanese Heart failure Patients: From the HIJ-HF cohort study.2017
Author(s)
Nagara K, Suzuki A, Itani R, Nonura A, Shimazaki K, Haruki S, Kogure T, Kikuchi N, Hattori H, Kawada E, Suzuki T, Shiga T, Uetsuka Y, Hagiwara N
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県立音楽堂(石川県金沢市)
Year and Date
2017-03-17
Related Report
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[Presentation] Ventricular Arrhythmias After Left Ventricular Assist Device.2017
Author(s)
Hattori H, Suzuki A, Shiga T, Serizawa N, Minami Y, Shoda M, Tateishi M, Umehara N, Saito S, Nunoda S, Yamazaki K, Nobuhisa N
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県立音楽堂(石川県金沢市)
Year and Date
2017-03-17
Related Report
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[Presentation] Left Ventricular Assist Device for Heart Failure Patients with Refractory Ventricular Tachyarrhythmias.2016
Author(s)
Suzuki A, Shiga T, Hattori H, Shoda M, Umehara N, Tsukui H, Nishinaka T, Saito S, Nunoda S, Yamazaki K, Hagiwara N
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(仙台)
Year and Date
2016-03-18
Related Report
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[Presentation] Pharmacological Prevention of Paroxysmal Atrial Fibrillation Recurrences in Symptomatic Patients. -A Multicenter Cross-over Study of Flecainide and Pilsicainide-2016
Author(s)
Shiga T, Yoshioka K, Watanabe E, Omori H, Yagi M, Okumura Y, Matsumoto N, Kusano K, Oshiro C, Ikeda T, Takahashi N, Komatsu T, Suzuki A, Suzuki T, Yamashita T
Organizer
第80回日本循環器学会学術集会
Place of Presentation
せんだい青葉山交流広場(仙台)
Year and Date
2016-03-18
Related Report
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[Presentation] Ventricular Tachyarrhythmias in Advanced Heart Failure Patients who Referred for Heart Transplantation Evaluation.2016
Author(s)
Hattori H, Suzuki A, Shiga T, Serizawa N, Suzuki T, Minami Y, Shoda M, Umehara N, Tsukui H, Nishinaka T, Saito S, Shitakura K, Nunoda S, Yamazaki K, Hagiwara N
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台市民会館(仙台)
Year and Date
2016-03-18
Related Report
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[Presentation] Prognostic Role of Atrial Tachyarrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia.2016
Author(s)
Kikuchi N, Shiga T, Suzuki A, Henmi R, Shibahashi E, Hattori H, Yagishita D, Serizawa N, Ejima K, Yumino D, Shoda M, Hagiwara N
Organizer
第80回日本循環器学会学術集会
Place of Presentation
せんだい青葉山交流広場(仙台)
Year and Date
2016-03-18
Related Report
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