Molecular preventative mechanism of vascular endothelial dysfunction in diabetes under GRK2 control
Project/Area Number |
15K21419
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
Pharmacology in pharmacy
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Research Institution | Hoshi University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 血管内皮障害 / 糖尿病 / GRK2 / 血管内皮機能不全 / GRK2 / 分子薬理学 |
Outline of Final Research Achievements |
We focused on vascular endothelial dysfunction to study the molecular preventative mechanism under GRK2 control in diabetes. We investigated vascular endothelial dysfunction in ob/ob mice and HUVECs treated high glucose and angiotensin II (Ang II). The present results clarified the relationship among hepatic GRK2, glucose homeostasis, and vascular endothelial function. Liver-targeting GRK2 siRNA delivery represents a novel therapeutic tool to restore glucose homeostasis and reduce endothelial dysfunction. Furthermore, the HUVECs data strongly indicate that high glucose and Ang II directly affect endothelial cells and the production of EEVs; the resultant EEVs aggravate endothelial dysfunction in mice aortas.
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Report
(3 results)
Research Products
(66 results)
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[Presentation] 自然発症高血圧ラット頸動脈におけるセロトニン誘発収縮反応に対する kinase inhibitors の影響2017
Author(s)
高橋 真理, 松本 貴之, 渡邊 駿, 竹内 美紀, 永田 麻子, 馬島 美紀, 諏訪 晶代, 野本 純, 保戸塚 里美, 指首 晴加, 安藤 眞, 井口 舞香, 小林 翔太, 田口 久美子, 小林 恒雄
Organizer
日本薬学会第137年会
Place of Presentation
仙台国際センター
Year and Date
2017-03-24
Related Report
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[Presentation] 2型糖尿病Goto-Kakizaki ラット頸動脈における収縮反応と3-phosphoinositide-dependent protein kinase 1の関連2017
Author(s)
馬島 美紀, 松本 貴之, 渡邊 駿, 竹内 美紀, 永田 麻子, 諏訪 晶代, 野本 純, 保戸塚 里美, 指首 晴加, 高橋 真理, 安藤 眞, 井口 舞香, 小林 翔太, 田口 久美子, 小林 恒雄
Organizer
日本薬学会第137年会
Place of Presentation
仙台国際センター
Year and Date
2017-03-24
Related Report
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