Development of a Chromatic Pupil Perimetry for Objective Visual Field Measurement

• Project/Area Number: 15K21468
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: MAEDA FUMIATSU 新潟医療福祉大学, 医療技術学部, 教授 (00341157)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 瞳孔視野 / 対光反射 / メラノプシン含有網膜神経節細胞 / 色光刺激 / 瞳孔

Outline of Final Research Achievements

We devised a new type of chromatic pupil perimeter for objective visual field measurement. This system consists of an LED type of liquid crystal display for generating chromatic stimulus and an infrared CCD camera with a macro lens for recording pupil responses.
With changing of the kind of stimulus, such as color, it may be possible for pupil perimetry to detect visual field disturbances more sharply than conventional method. We supposed that a chromatic pupil perimeter can be used in clinical applications for evaluating an objective visual field easily.

Research Products

• [Int'l Joint Research] University of Tuebingen(Germany)
• [Journal Article] Development of a chromatic pupillography protocol for the first gene therapy trial in patients with CNGA3-linked achromatopsia (2017)
  • Author(s): Lisowska J, Lisowski L, Kelbsch C, Maeda F, Richter P, Kohl S, Zobor D, Strasser T, Stingl K, Zrenner E, Peters T, Wilhelm H, Fischer MD, Wilhelm B; RD-CURE Consortium
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 58 Issue: 2 Pages: 1274-1282
  • DOI: 10.1167/iovs.16-20505
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pupil light reflex or pupil light response? (2017)
  • Author(s): 前田史篤
  • Journal Title: Japanese Journal of Visual Science Volume: 38 Issue: 1 Pages: 1-4
  • DOI: 10.11432/jpnjvissci.38.1
  • NAID: 130006943334
  • ISSN: 0916-8273, 2188-0522
  • Acknowledgement Compliant
• [Journal Article] Analysis of retinal function using chromatic pupillography in retinitis pigmentosa and the relationship to electrically evoked phosphine thresholds (2016)
  • Author(s): Kelbsch C, Maeda F, Lisowska J, Lisowski L, Strasser T, Stingl K, Wilhelm B, Wilhelm H, Peters T
  • Journal Title: Acta Ophthalmol Volume: － Issue: 4
  • DOI: 10.1111/aos.13259
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pupillary responses driven by ipRGCs and classical photoreceptors are impaired in glaucoma (2016)
  • Author(s): Kelbsch C, Maeda F, Strasser T, Blumenstock G, Wilhelm B, Wilhelm H, Peters T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 7 Pages: 1361-1370
  • DOI: 10.1007/s00417-016-3351-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 古くて新しい瞳孔のトピックス (2016)
  • Author(s): 前田史篤
  • Journal Title: Japanese Journal of Visual Science Volume: 37 Issue: 2 Pages: 68-70
  • DOI: 10.11432/jpnjvissci.37.68
  • NAID: 130005407678
  • ISSN: 0916-8273, 2188-0522
• [Journal Article] Association between a relative afferent pupillary defect using pupillography and inner retinal atrophy in optic nerve disease. (2015)
  • Author(s): Takizawa G, Miki A, Maeda F, Goto K, Araki S, Ieki Y, Kiryu J, Yaoeda K
  • Journal Title: Clinical Ophthalmology Volume: 9 Pages: 1895-1903
  • DOI: 10.2147/opth.s91278
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] もの言わぬ瞳孔のもの語り －瞳孔の動きから網膜の機能を測る－ (2016)
  • Author(s): 前田史篤
  • Organizer: 第5回 Lecture And Discussion for Expert Retina in Sapporo
  • Place of Presentation: ノバルティスファーマ 札幌営業所 (北海道・札幌市)
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] 瞳孔解析からわかる視機能 (2016)
  • Author(s): 前田史篤
  • Organizer: 第5回日本視野学会
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市)
  • Invited
• [Presentation] Development of a training system for the measurement of manual kinetic perimetry using the Goldmann perimeter (2016)
  • Author(s): Ubukata H, Maeda F, Masuda O, Shindo M, Kawachi R, Kobayashi A, Kani K, Abe H
  • Organizer: 22nd International Visual Field Imaging Symposium
  • Place of Presentation: Castle of Udine (Udine, Italy)
  • Int'l Joint Research
• [Presentation] 調節微動解析装置による自覚的疲労症状の検討 (2015)
  • Author(s): 進藤真紀，前田史篤，阿部春樹
  • Organizer: 第51回日本眼光学学会総会
  • Place of Presentation: 岡山コンベンションセンター (岡山県・岡山市)
  • Year and Date: 2015-09-26
• [Presentation] Development of a chromatic pupillography protocol for the first gene therapy trial in patients with CNGA3-linked achromatopsia (2015)
  • Author(s): Wilhelm B, Peters T, Maeda F, Lisowska J, Lisowski L, Kelbsch C, Strasser T, Zobor D, Wilhelm H, Fischer D
  • Organizer: 31st International Pupil Colloquium
  • Place of Presentation: Pembroke College (イギリス)
  • Year and Date: 2015-09-15
  • Int'l Joint Research
• [Presentation] Objective analysis of retinal function using chromatic pupillography in advanced retinitis pigmentosa and the relationship to the electrically evoked phosphine thresholds (2015)
  • Author(s): Kelbsch C, Maeda F, Lisowska J, Lisowski L, Strasser T, Stingl K, Wilhelm B, Wilhelm H, Peters T
  • Organizer: 31st International Pupil Colloquium
  • Place of Presentation: Pembroke College (イギリス)
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] Color pupillography in glaucoma and ocular hypertension - the role of the intrinsically photosensitive retinal ganglion cells (2015)
  • Author(s): Kelbsch C, Maeda F, Strasser T, Peters T, Wilhelm B, Wilhelm H
  • Organizer: 2015 ARVO annual meeting
  • Place of Presentation: Colorado Convention Center (アメリカ合衆国)
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] 遠近調節と近遠調節に対する瞳孔径の変化 (2015)
  • Author(s): 前田史篤，進藤真紀，高橋憲一，魚里博，阿部春樹
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: ロイトン札幌 (北海道・札幌市)
  • Year and Date: 2015-04-16
• [Presentation] 遠近調節と近遠調節に対する調節微動高周波成分出現頻度と調節反応量の変化 (2015)
  • Author(s): 進藤真紀，前田史篤，高橋憲一，魚里博，阿部春樹
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: さっぽろ芸文館 (北海道・札幌市)
  • Year and Date: 2015-04-16
• [Book] 眼科検査ガイド第2版 (2016)
  • Author(s): 前田史篤
  • Publisher: 文光堂
• [Book] 眼科検査ガイド. 瞳孔視野計 (2016)
  • Author(s): 前田史篤
  • Publisher: 文光堂