| Project/Area Number |
15K21510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
Radiation science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Hirota Yuki 大阪医科大学, 医学部, 非常勤医師 (80707331)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | グリオーマ / 悪性神経膠腫 / 晩発性放射線脳障害 / 放射線脳壊死 / 治療後再発 / ケモカイン / 放射線治療 / グリオーマ幹細胞 / 神経膠腫 / 再発 / 放射線障害 / 遅発性放射線障害 / X線 / 腫瘍幹細胞 / miRNA / 腫瘍再発 |
|---|
| Outline of Final Research Achievements |
Glioblastoma is one of incurable malignant brain tumors. Our present study demonstrated that the chronic pathophysiological changes after X-ray irradiation against the tumor may advantage its abilities of proliferation, invasion and angiogenesis, which might be able to promote the tumor recurrence paradoxically. Through examining the biological mechanisms of this phenomenon, we found out several candidates of the therapeutic molecular targets for suppressing the tumor relapse after radiotherapy.
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