| Project/Area Number |
15K21605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
Tumor biology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Okamoto Keiji 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 研究員 (30533682)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | DNA損傷応答 / DNA修復反応 / ポリADPリボシル化 / タンキラーゼ / DNA損傷応答反応 / X線感受性 |
|---|
| Outline of Final Research Achievements |
Tankyrase which is now focused on the potential target for the anti-cancer drug is known to be a multi-functional protein because of its function with a lot of different binding partners but the whole function in the cell remains to be elusive. I examined the role of Tankyrase for DNA damage response (DDR) and repair pathway. As a result, lung cancer cell line A549 showed hyper sensitivity for DNA damage in the combination with Tankyrase inhibitor. In addition, Tankyrase showed to localize to DNA double strand break sites. These data suggest Tankyrase plays a role for DNA repair as a component of DDR complex.
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