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Functional analysis of Tankyrase for DNA damage response and repair

Research Project

Project/Area Number 15K21605
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Tumor biology
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

Okamoto Keiji  公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 研究員 (30533682)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsDNA損傷応答 / DNA修復反応 / ポリADPリボシル化 / タンキラーゼ / DNA損傷応答反応 / X線感受性
Outline of Final Research Achievements

Tankyrase which is now focused on the potential target for the anti-cancer drug is known to be a multi-functional protein because of its function with a lot of different binding partners but the whole function in the cell remains to be elusive. I examined the role of Tankyrase for DNA damage response (DDR) and repair pathway. As a result, lung cancer cell line A549 showed hyper sensitivity for DNA damage in the combination with Tankyrase inhibitor. In addition, Tankyrase showed to localize to DNA double strand break sites. These data suggest Tankyrase plays a role for DNA repair as a component of DDR complex.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] タンキラーゼによる相同組換え反応制御2016

    • Author(s)
      岡本啓治、大石智一、黒岩美佳、家村俊一郎、夏目徹、清宮啓之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] タンキラーゼによるインターフェロン反応の制御2015

    • Author(s)
      岡本啓治、大石智一、黒岩美佳、家村俊一郎、夏目徹、清宮啓之
    • Organizer
      第38回日本分子生物学会
    • Place of Presentation
      神戸ポートピアランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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