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Examination of the relationship between EGFR mutant allele frequency and efficacy of EGFR inhibitor of tissue samples and blood samples in patient with lung cancer

Research Project

Project/Area Number 15K21688
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Tumor therapeutics
Research InstitutionShizuoka Cancer Center Research Institute

Principal Investigator

Akira Ono  静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (50441027)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺癌 / リキッドバイオプシー / allele frequency / 末梢血循環腫瘍DNA / 末梢血中循環腫瘍DNA / 体細胞遺伝子変異 / クローン / サブクローン / 腫瘍内不均一性 / 腫瘍診断学 / 分子標的治療 / デジタルPCR / EGFR遺伝子変異
Outline of Final Research Achievements

Ultrasensitive EGFR gene mutation measuring system was constructed using tissue samples and blood samples in non-small cell lung cancer patients.This result is significant in realizing quantification of EGFR gene mutation with non-invasive methoed. With development future genome medicine, we considered important in evaluating choice of treatment policy and efficacy of treatment based on the evaluation of allele frequency in EGFR gene mutation and other somatic gene mutataion.

Academic Significance and Societal Importance of the Research Achievements

侵襲性の低い血液検体での遺伝子検査方法の確立が、今後のがんゲノム医療の発展に寄与し得ると考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Plasma epidermal growth factor receptor mutation testing with achip-based digital PCR system in patients with advanced non-smallcell lung cancer2017

    • Author(s)
      Kasahara N, Kenmotsu H, Serizawa M, Umehara R, Ono A, Hisamatsu Y, Wakuda K, Omori S, Nakashima K, Taira T, Naito T, Murakami H, Koh Y, Mori K, Endo M, Nakajima T, Yamada M, Kusuhara M, Takahashi T.
    • Journal Title

      Lung Cancer

      Volume: 106 Pages: 138-144

    • DOI

      10.1016/j.lungcan.2017.02.001

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Plasma epidermal growth factor recepter mutation (EGFR) testing in advanced non-small cell lung cancer patients harboring EGFR mutations by chip-based digital PCR system2016

    • Author(s)
      Norimitsu Kasahara, Hirotsugu Kenmotsu, Masakuni Serizawa, Rina Umehara, Akira Ono, Kazushige Wakuda, Shota Omori, Kazuhisa Nakashima, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Noriaki Sunaga, Yasuhiro Koh, Keita Mori, Masahiro Endo, Takashi Nakajima, Masanobu Yamada, Masatoshi Kusuhara, Toshiaki Takahashi
    • Organizer
      American Association for Cancer Research Annual Meeting 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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