| Project/Area Number |
15K21764
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| Research Category |
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Suzuki Minoru
Saito Hiroyuki
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| Project Period (FY) |
2017 – 2019
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
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| Keywords | メソポーラスシリカナノ粒子 / がん蓄積 / がんの鶏卵モデル / がんスフェロイド / ホウ素中性子捕捉療法 / 単色X線 / オージェ効果 / ホウ素含有メソポーラスシリカナノ粒子 / 鶏卵のがんモデル / がんへの蓄積 / 癌へのターゲティング / 鶏卵の癌モデル / ナノ材料 / ナノバイオ / 放射線 |
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| Outline of Final Research Achievements |
This research led to the development of various mesoporous silica-based nanoparticles that are promising for cancer therapy. Because these nanoparticles possess a large surface area, various chemicals can be attached to the nanoparticles. In one instance, we bound anticancer drugs and demonstrated the use of the nanoparticles for drug delivery. In another approach, we attached boron containing chemicals so that the nanoparticles can be used for boron neutron capture therapy. In yet another approach, we prepared nanoparticles containing gadolinium. This gadolinium containing nanoparticles could be used in combination with monochromatic X-ray to provide a new type of radiation therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の意義はメソポーラスシリカをベースにした新規のナノ粒子を開発することができた点にある。これらのナノ材料は抗がん剤のデリバリーに有効であり、またホウ素中性子捕捉療法や新規の放射線治療の開発に寄与する。特にガドリニウム含有ナノ粒子と単色X線を組み合わせた放射線実験により新規放射線治療の可能性を提示した。
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