| Project/Area Number |
15KK0025
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental engineering and reduction of environmental burden
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Nomura Toshiyuki 大阪府立大学, 工学(系)研究科(研究院), 准教授 (00285305)
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| Research Collaborator |
Routh Alexander F. University of Cambridge, Department of Chemical Engineering and Biotechnology, Professor
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| Project Period (FY) |
2016 – 2018
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Keywords | 環境材料 / 薬物送達システム / コロイドソーム |
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| Outline of Final Research Achievements |
In this study, we investigated environment-friendly synthetic methods for the encapsulation of water-soluble substances in biodegradable poly lactic-co-glycolic acid (PLGA) polymer particles. As a result, PLGA nanoparticles generated using vegetable oil as a continuous phase self-assembled on water droplets to stabilize W/O (Water in Oil) emulsion and then the polymer particles were fused by heating, leading that PLGA microcapsules capable of encapsulating water soluble polysaccharides, proteins and microorganisms have been successfully synthesized.
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| Academic Significance and Societal Importance of the Research Achievements |
PLGAは、生体適合性、生分解性、薬物徐放性に優れたポリマー基材であるが、疎水性のため、親水性物質の封入には適していない。また、PLGA粒子の合成には、生体に有害な化学物質が使用される。本研究で合成したPLGAマイクロカプセルは、内相が水であるため、親水性物質の封入が可能であるたけでなく、その合成プロセスにおいて有害な化学物質をまったく使用していないため、環境調和型の薬物送達システムを可能とする。
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