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Research on endotheliaisation of optimal stent struts under blood flow(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0197
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Ohta Makoto  東北大学, 流体科学研究所, 教授 (20400418)

Research Collaborator Sen Itsu  マッコーリ大学, Department of Biomedical Sciences, 教授
Hirsh Sven  ZHAW School of Life Sciences and Facility Management, Fachstelle Biomedical Simulation, 教授
Fridrici Vincent  ECL, Maître de conférences en matériaux, 准教授
Project Period (FY) 2016 – 2018
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsステント / 内皮細胞 / 遊走 / 血流 / モデル / Deep learning / CFD / 最適化ステント / 自動判別プログラム / 流れ付加 / 最適化デザイン / 血流シミュレーション
Outline of Final Research Achievements

Based on the international collaborations with three places, we developed a smart deployment program of stent, a high efficient method for finding an aneurysm and a new material for biomodel. Also, we found a replying of cells from the wall shear stress. Especially, we successfully developed a new chamber with a strut and the results have a consistency to the previous results saying wall shear stress replying. This means that we find a optimal strut. This results is opened in international conference on 2019 and journal paper. These findings show the possibility of a pipeline from diagnosis of aneurysm to design of optimal stent.

Academic Significance and Societal Importance of the Research Achievements

本研究成果の学術的意義は,流れに起因する細胞応答を対する最適なステントデザインの構築するための要素技術を開発し,パイプラインを構築した事にある.これにより,個別患者に対応するステントデザインを提示することが可能になり,医療機器の質の向上に貢献した.また,これらのプログラムの一部を応用して,動脈瘤提示のプログラムが開発された.さらに本研究で開発したチャンバーは,流れ付加中の材料表面の内皮化を評価する方法として認められ,新たな共同研究に繋がった.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (55 results)

All 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results) Presentation (40 results) (of which Int'l Joint Research: 32 results,  Invited: 7 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] リヨン理工中央大学(フランス)2018

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ジュネーブ大学(スイス)2017

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マッコーリ大学(オーストラリア)2017

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Influence of TGF-β1 expression in endothelial cells on smooth muscle cell phenotypes and MMP production under shear stress in a co-culture model2019

    • Author(s)
      Xiaobo Han, Naoya Sakamoto, Noriko Tomita, Hui Meng, Masaaki Sato, Makoto Ohta
    • Journal Title

      Cytotechnology

      Volume: 71 Issue: 2 Pages: 489-496

    • DOI

      10.1007/s10616-018-0268-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The effect of contact force during radiofrequency catheter ablation using a vibrating catheter: New cooling method for catheter ablation2019

    • Author(s)
      Kaihong Yu, Tetsui Yamashita, Shigeaki Shingyochi, Kazuo Matsumoto, Atsuki Komiya, Makoto Ohta
    • Journal Title

      Technology and Health Care

      Volume: 28 Issue: 6 Pages: 1-13

    • DOI

      10.3233/thc-191639

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Research on Arterial Stiffness Status in Type 2 Diabetic Patients Based on Pulse Waveform Characteristics2018

    • Author(s)
      Li Gaoyang、Song Xiaorui、Qiao Aike、Ohta Makoto
    • Journal Title

      Computer Modeling in Engineering & Sciences

      Volume: 117 Issue: 2 Pages: 143-155

    • DOI

      10.31614/cmes.2018.04100

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational Fluid Dynamics Analysis to Predict Endothelial Cells Migration during Flow Exposure Experiment with Placement of Two Stent Wires2018

    • Author(s)
      Narendra Kurnia Putra, Zi Wang, Hitomi Anzai, Makoto Ohta
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc.

      Volume: - Pages: 5454-5457

    • DOI

      10.1109/embc.2018.8513517

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haemodynamic effects of stent diameter and compaction ratio on flowdiversion treatment of intracranial aneurysms: A numerical study of a successful and an unsuccessful case2017

    • Author(s)
      Mingzi Zhang, Yujie Li, Xi Zhao, David I. Verrelli, Winston Chong, Makoto Ohta, Yi Qian
    • Journal Title

      Jounal of Biomechanics

      Volume: 58 Pages: 179-186

    • DOI

      10.1016/j.jbiomech.2017.05.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Advanced Technologies of Medical Active Catheter2017

    • Author(s)
      芳賀 洋一,太田 信,松永 忠雄
    • Journal Title

      JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS

      Volume: 62 Issue: 1 Pages: 30-36

    • DOI

      10.18914/tribologist.62.01_30

    • NAID

      130005289669

    • ISSN
      0915-1168, 2189-9967
    • Related Report
      2017 Research-status Report
  • [Journal Article] Biomodel of Hard Tissue for Dynamic Mechanical Testing of Medical Device2017

    • Author(s)
      Makoto Ohta, Dominik Huesener, Yuta Muramoto, Simon Tupin
    • Journal Title

      Reports of the Institute of Fluid. Science

      Volume: 29 Pages: 11-20

    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fabrication, Observation and Tribological Characterization of Acrylic Composite Materials for Bone Biomodel for Surgical Drilling2018

    • Author(s)
      Yuta Muramoto, Gaetan Bouvard, Makoto Ohta, Vincent Fridrici, Philippe Kapsa
    • Organizer
      30eme Jornees Internationals Francophones de Tribologie (JIFT2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of fabrication machine for 3-dimensional hydrogel blood vessel biomodels2018

    • Author(s)
      Yasutomo Shimizu, Hiroshi Yoshida, Tadao Matsunaga, Yoichi Haga, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiobjective Optimization of Stent Design towards In-Stent Restenosis2018

    • Author(s)
      Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can morphology or haemodynamic characteristics of verteebrobasilar system be identifier of hypertension2018

    • Author(s)
      Ko Kitamura, Yujie Li, Mingzi Zhang, Hitomi Anzai, Shuji Mugikura, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Experimental analysis of AAA treatment by multi-layer stent and fate of abdominal aortic branches2018

    • Author(s)
      Simon Tupin, Kei Takase and Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drilling of PMMA-based bone biomodel: effect of temperature elevation during drilling2018

    • Author(s)
      Yuta Muramoto, Gaetan Bouvard, Vincent Fridrici, Philippe Kapsa, Fredrik Lundell, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dose hypertension history affect morphology or hemodynamic characteristics of ertebrobasilar system? Retrospective study of 249 patients dagnosed with hypertension.2018

    • Author(s)
      Yujie Li, Mingzi Zhang, Ko Kitamura, Hitomi anzai, Shuji Mugikura, and Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] INCOMPLETE EXPANSION OF FLOW-DIVERTING STENT AFFECTS ANEURYSM HAEMODYNAMICS: A QUANTITATIVE COMPARISON BETWEEN TREATMENTS WITH DIFFERENT SEVERITIES OF INCOMPLETE EXPANSION OCCURRING WITHIN DIFFERENT SEGMENTS OF THE PARENT ARTERY2018

    • Author(s)
      Mingzi Zhang, Yujie Li, Shin-ichiro Sugiyama, David I. Verrelli, Yasushi Matsumoto, Teiji Tominaga, Yi Qian, and Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PIV MEASUREMENT IN AN IDEAL ANEURYSMAL MODEL USING A TRANSPARENT COIL MODEL2018

    • Author(s)
      Makoto OHTA, Masanori KUZE, Simon TUPIN, Kaihong YU, Yasutomo SHIMIZU, Hitomi ANZAI
    • Organizer
      Conference on Modelling Fluid Flow (CMFF’18) The 17th International Conference on Fluid Flow Technologies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Research on Arterial Stiffness in Type 2 Diabetic Patients Based on Pulse Wave Analysis2018

    • Author(s)
      Gaoyang Li, Xiaorui Song, Aike Qiao, Makoto Ohta
    • Organizer
      ICFD (Internatinal Conference of Fluid Dynamics 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hemodynamic Study on Coronary Artery Aneurysms with Bypass Surgery2018

    • Author(s)
      Haoran Wang, Hitomi Anzai, Makoto Ohta, Youjun Liu
    • Organizer
      ICFD (Internatinal Conference of Fluid Dynamics 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Masami Matsuura, Simon Tupin, Makoto Ohta2018

    • Author(s)
      Masami Matsuura, Simon Tupin, Makoto Ohta
    • Organizer
      ASME 2018 International Mechanical Engineering Congress and Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 格子ボルツマン法を用いたステントストラット配置が脳動脈瘤流れに与える影響の解析2018

    • Author(s)
      渡邉和浩, 安西眸, 太田信
    • Organizer
      第23回計算工学講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 畳み込みニューラルネットワークに基づくアテローム性動脈硬化症患者のパルスパターン認識2018

    • Author(s)
      Gaoyang Li, Hitomi Anzai, Kazuhiro Watanabe, Aike Qiao, Xiaorui Song, Makoto Ohta
    • Organizer
      日本機械学会 第29回バイオフロンティア講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳動脈瘤抽出用ニューラルネットワークにおける,入力画像の表現方法の違いによる判定精度への影響2018

    • Author(s)
      渡邉和浩, 安西眸, Norman Juchler, Sven Hirsch, Philippe Bijlenga, 太田信
    • Organizer
      第31回バイオエンジニアリング講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of temperature elevation on drilling of acrylic composite materials for bone biomodel2018

    • Author(s)
      Yuta Muramoto, Dominik Huesener, Gaetan Bouvard, Makoto Ohta, Vincent Fridrici, Philippe Kapsa
    • Organizer
      ELyT Workshop 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Variation of strut parameter effects with wall deformation on stent deployment via surrogate model2017

    • Author(s)
      Narendra Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, and Makoto Ohta
    • Organizer
      5th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] EC Migration Analysis by CFD with a Strut in Flow Chamber2017

    • Author(s)
      Makoto OHTA, Tomohito WATANABE, Xiaobo HAN, and Hitomi ANZAI
    • Organizer
      5th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Where does CFD identify lesion instability in small aneurysms?2017

    • Author(s)
      Hitomi Anzai, Norman Juchler, Makoto Ohta, Sven Hirsch, Daniel A. Ruefenacht, and Isabel Wanke
    • Organizer
      5th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparative Study between Different Strut’s Cross Section Shape on Minimizing Low Wall Shear Stress along Stent Vicinity via Surrogate-based Optimization2017

    • Author(s)
      Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta
    • Organizer
      12th World Congress of Structural and Multidisciplinary Optimisation
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A CFD-BASED GENETIC ALGORITHM APPLIED TO THE DESIGN OF FLOW-DIVERTING STENT FOR IDENTIFYING THE WIRE CONFIGURATION THAT MAXIMALLY DISRUPTS THE BUNDLE OF ANEURYSM INFLOW2017

    • Author(s)
      Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Yi Qian, Makoto Ohta
    • Organizer
      Summer Biomechanics, Bioengineering and Biotransport Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] In Search for a Better Stent: Surrogate based Multi-Objective Optimization of Stent Design under Influence of Vessel Wall Deformation2017

    • Author(s)
      Narendra Kurnia Putra, Yujie Li, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta
    • Organizer
      Proceedings of 39th annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Applying Computer Simulation to the Design of Flow-diversion Treatment for Intracranial Aneurysms2017

    • Author(s)
      Mingzi Zhang, Yujie Li, Xi Zhao, David I. Verrelli, Winston Chong, Makoto Ohta, Yi Qian
    • Organizer
      Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Applying virtual stent deployment to syudy flow-diversion treatment for intracranial aneurysms: the effect of stent compaction on post-treatment wire configuration2017

    • Author(s)
      Mingzi Zhang, Yujie Li, Xi Zhao, David I. Verrelli, Winston Chong, Makoto Ohta, Yi Qian
    • Organizer
      Proceedings of the 8th International Conference on Computational Methods
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Stent Design Optimization based on Kriging Surrogate Model under Deformed Vessel Wall: Pulsatile Inlet Flow2017

    • Author(s)
      Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta
    • Organizer
      Proceedings of the 5th International Conference on Instrumentation, Control and Automation
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] HOW TO FIND OUT OPTIMAL INTERVAL OF STRUTS FOR CEREBRAL ANEURYSM?2017

    • Author(s)
      Kazuhiro Watanabe, Hitomi Anzai, Makoto Ohta
    • Organizer
      5th Switzerland-Japan Workshop on Biomechanics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ANALYSYS OF OPTIMAL STENT STRUCTURE FOR FLOW STAGNATION USING SELF-ORGANIZING MAPS2017

    • Author(s)
      Hitomi Anzai, Yuuki Yoshida, Makoto Ohta
    • Organizer
      5th Switzerland-Japan Workshop on Biomechanics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Drilling of PMMA-based bone biomodel: effect of additives2017

    • Author(s)
      Yuta MURAMOTO, Vincent FRIDRICI, Philippe KAPSA, Gaёtan BOUVARD, Fredrik Lundell, Makoto OHTA
    • Organizer
      The 6th World Tribology Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Automatic detection and localization of intracranial aneurysms by means of deep learning2017

    • Author(s)
      Kazuhiro Watanabe, Norman Juchler, Hitomi Anzai, Makoto Ohta, Sven Hirsch
    • Organizer
      Deep Learning Day 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a poly (vinyl alcohol) hydrogel phantom to allow physical measurtement in ultrasonographic conditions: a model for scatter2017

    • Author(s)
      Ren TAKAHASHI, Kazuma TAMURA, Tadashi YAMAGUCHI, Yasutomo Shimizu, Makoto Ohta
    • Organizer
      2017 IEEE International Conferencd on Cyborg and Bionic Systems
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Research of high-speed contact with medical devices2017

    • Author(s)
      Yuta Muramoto, Gatan Bouvard, Vincent Fridrici, Philippe Kapsa, Fredrik Lundell, Makoto Ohta
    • Organizer
      The 17th International Symposium on Advanced Fluid Information
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of Program for surveying stent strut position2017

    • Author(s)
      Makoto Ohta, Kazuhiro Watanabe, Mingzi, Zhang, Bastien Chopard, Hitomi Anzai
    • Organizer
      The 17th International Symposium on Advanced Fluid Information
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of Pulsatile Inlet Conditions on the Hemodynamic Conditions of Stent with Deformed Wall Simulations2017

    • Author(s)
      Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta
    • Organizer
      ICICI-BME 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of endovascular treatment environment for medical training and simulation using coiling2017

    • Author(s)
      Yasutomo Shimizu, Simon Tupin, Kaihong Yu, Soyoka Osaki, Hiroshi Yoshida, Masaaki Shojima, Tadao Matsunaga, Yoichi Haga, Makoto Ohta
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] フローダイバータステントを用いた脳動脈瘤治療に対する数値シミュレーションの応用2017

    • Author(s)
      張 明子,李 玉潔,安西 眸,銭 逸,太田 信
    • Organizer
      日本機械学会 2017年度年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Artery Biomodel for Use as Evaluations of Medical Device2017

    • Author(s)
      日本機械学会 2017年度年次大会
    • Organizer
      The 5th International Conference on Instrumentation, Control and Automation 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 血管モデルの開発と動物実験2017

    • Author(s)
      太田 信,大西 泰平,Simon TUPIN,清水 康智,于 凱鴻,安西 眸
    • Organizer
      第64回日本実験動物学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 教育用,評価用,プレオペ用血管モデルの開発2017

    • Author(s)
      太田 信,Simon TUPIN,清水 康智,于 凱鴻,安西 眸
    • Organizer
      第53回日本医学放射線学会秋期臨床大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 血管モデルの開発とニーズ2017

    • Author(s)
      太田 信
    • Organizer
      異分野連携のノウハウ共有と水平展開を目指す(非公開)ワークショップ
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 2D Vertex Model of Cell Monolayers and its Applications2017

    • Author(s)
      Aziza Merzouki, Orestis Malaspinas, Aurelien Roux, Anastasiya Trushko, Patrycja Paruch, Guillaume Rapin, Hitomi Anzai, Makoto Ohta, Michel Milinkovitch, Athanasia Tzika, Bastien Chopard
    • Organizer
      5th Switzerland-Japan Workshop on Biomechanics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 太田研

    • URL

      http://www.ifs.tohoku.ac.jp/bfc/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 管腔臓器モデルユニットおよび管腔臓器モデルユニットの製造方法2017

    • Inventor(s)
      芳賀洋一,太田信,清水康智,その他6名
    • Industrial Property Rights Holder
      芳賀洋一,太田信,清水康智,その他6名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-091917
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 生体組織の模型の乾燥体及び生体組織の模型の乾燥体に対する溶媒含有方法2017

    • Inventor(s)
      太田 信,清水康智,大西泰平
    • Industrial Property Rights Holder
      太田 信,清水康智,大西泰平
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-110128
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] ハイドロゲル組成物,生体組織の模型,及び生体組織の製造方法2017

    • Inventor(s)
      太田 信,清水康智,高橋 廉
    • Industrial Property Rights Holder
      太田 信,清水康智,高橋 廉
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-158316
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report
  • [Funded Workshop] ELyT Workshop 20182018

    • Related Report
      2018 Annual Research Report

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Published: 2016-10-04   Modified: 2022-01-27  

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