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Control of Protein Mass Transfer: An Active Control Utilizing Variations of Surrounding Conditions(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0227
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Thermal engineering
Research InstitutionTohoku University

Principal Investigator

Komiya Atsuki  東北大学, 流体科学研究所, 教授 (60371142)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywordsタンパク質 / 物質拡散 / 結晶成長 / 位相シフト干渉計 / 機能性膜 / 物質移動 / 物質流束 / 蛋白質 / 物性実験 / 可視化
Outline of Final Research Achievements

In this study, a series of visualization experiments of protein mass transport phenomena through special membranes was performed and a potential of its control was evaluated. Forming a framework of international collaborative research with material scientist in France, the experiments were parametrically conducted. The experimental results reveal that the protein mass transport process was strongly affected by the structure of channels, and total mass passing through the membrane was affected by the concentrations at the vicinity of inlet and outlet of channels and free diffusion process in solution area.

Academic Significance and Societal Importance of the Research Achievements

本国際共同研究で得られる成果は熱工学の分野にとどまらず,多くの分野に貢献できると考えられる.特に,本研究におけるタンパク質能動制御の可能性および実現性の提案により,製薬および医工学分野において各種ニーズに対応したタンパク質輸送の革新的な制御技術の開発が大いに期待できる.
生体個体の「内側」における物理的・化学的現象に焦点を当てた本申請課題の貢献は,熱工学にとどまらず多くの学術的波及効果をもたらすことができる.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Int'l Joint Research (1 results) Presentation (6 results) (of which Int'l Joint Research: 6 results)

  • [Int'l Joint Research] INSA de Lyon(国立応用科学院リヨン校)(フランス)2018

    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluation of the Relations between Hindered Diffusion Process of Protein and Membrane Structure2019

    • Author(s)
      Atsuki Komiya, Ryo Watanabe, Hani Alkitabi Aldaftari, Shuichi Moriya and Sebastien Livi
    • Organizer
      The Second Pacific Rim Thermal Engineering Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of protein mass flux through porous membrane2019

    • Author(s)
      Ryo Watanabe, Shuichi Moriya, Sebastien Livi and Atsuki Komiya
    • Organizer
      ELyT Workshop 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative Evaluation of the Influence of Membrane Structure on Protein Mass Diffusion2019

    • Author(s)
      Ryo Watanabe, Shuichi Moriya, Sebastien Livi, Hani Alkitabi Aldaftari and Atsuki Komiya
    • Organizer
      16th International Conference on Flow Dynamics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein Mass Transfer Control by Using Hindered Diffusion in Membrane2019

    • Author(s)
      Atsuki Komiya, Ryo Watanabe and Sbastien Livi
    • Organizer
      19th International Symposium on Advanced Fluid Information
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Experimental Study on Active Control of Protein Mass Flux by Functional Membrane2018

    • Author(s)
      Atsuki Komiya and Sebastien Livi
    • Organizer
      ELyT Workshop 2018
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Experimental Study on Active Control of Protein Transport Phenomena by Membrane2017

    • Author(s)
      Atsuki Komiya and Sebastien Livi
    • Organizer
      The 28th International Symposium on Transport Phenomena (ISTP-28)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-10-04   Modified: 2021-02-19  

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