Study on physiological significance and mechanisms of a novel hypothalamic secretory protein(Fostering Joint International Research)
| Project/Area Number |
15KK0259
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Hiroshima University |
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Principal Investigator |
Ukena Kazuyoshi 広島大学, 統合生命科学研究科(総), 教授 (10304370)
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| Project Period (FY) |
2016 – 2019
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Keywords | 視床下部 / 分泌性小タンパク質 / 摂食行動 / 脂肪蓄積 / de novo脂肪合成 / 分泌タンパク質 / サーカディアンリズム / ハムスター |
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| Outline of Final Research Achievements |
We recently identified a novel cDNA encoding a small secretory protein of 80 amino acid residues, termed neurosecretory protein GL (NPGL), from the chicken hypothalamus. Homologs of NPGL have been reported to be present in mammals. In this study, we investigated the function of NPGL in mice and rats. We found that NPGL mRNA is robustly expressed in the lateroposterior part of the arcuate nucleus in the hypothalamus. NPGL-immunoreactive fibers were observed in close anatomical contact with POMC neurons in the arcuate nucleus. Furthermore, NPGL increased food intake in mice. We also found that NPGL increased food intake and the mass of white adipose tissue (WAT) in rats. NPGL induced carbohydrate intake. NPGL mRNA expression was upregulated by fasting and low insulin levels. These results point to NPGL as a novel neuronal regulator that drives food intake and fat accumulation through de novo lipogenesis and acts to maintain a steady-state fat level in rodents.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、他の研究グループが発見した既知の脳因子に関する研究ではなく、自らが発見した新規の脳因子NPGLに関する研究を推進し、極めて学術的独自性と創造性が高い成果を得ることができた。本来、脂肪蓄積は飢餓に備えた自己防御機構の一つである。脂肪組織でのde novo脂肪合成は糖代謝の改善等の報告が最近なされ始めており、NPGLによる脂肪組織のde novo脂肪合成制御は、我々ヒトの生活習慣病改善に役立つ可能性がある。
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Localization and function of neurosecretory protein GM, a novel small secretory protein, in the chicken hypothalamus.2018
Author(s)
Shikano K, Bessho Y, Kato M, Iwakoshi-Ukena E, Taniuchi S, Furumitsu M, Tachibana T, Bentley GE, Kriegsfeld LJ, Ukena K.
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 704-704
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.2017
Author(s)
Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neurosecretory protein GL, a hypothalamic small secretory protein, participates in energy homeostasis in male mice2017
Author(s)
Matsuura D＊, Shikano K＊, Saito T＊, Iwakoshi-Ukena E, Furumitsu M, Ochi Y, Sato M, Bentley GE, Kriegsfeld LJ, Ukena K
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Journal Title
Endocrinology
Volume: 158
Issue: 5
Pages: 1120-1129
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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