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Study on physiological significance and mechanisms of a novel hypothalamic secretory protein(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0259
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Morphology/Structure
Research InstitutionHiroshima University

Principal Investigator

Ukena Kazuyoshi  広島大学, 統合生命科学研究科(総), 教授 (10304370)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Keywords視床下部 / 分泌性小タンパク質 / 摂食行動 / 脂肪蓄積 / de novo脂肪合成 / 分泌タンパク質 / サーカディアンリズム / ハムスター
Outline of Final Research Achievements

We recently identified a novel cDNA encoding a small secretory protein of 80 amino acid residues, termed neurosecretory protein GL (NPGL), from the chicken hypothalamus. Homologs of NPGL have been reported to be present in mammals. In this study, we investigated the function of NPGL in mice and rats. We found that NPGL mRNA is robustly expressed in the lateroposterior part of the arcuate nucleus in the hypothalamus. NPGL-immunoreactive fibers were observed in close anatomical contact with POMC neurons in the arcuate nucleus. Furthermore, NPGL increased food intake in mice. We also found that NPGL increased food intake and the mass of white adipose tissue (WAT) in rats. NPGL induced carbohydrate intake. NPGL mRNA expression was upregulated by fasting and low insulin levels. These results point to NPGL as a novel neuronal regulator that drives food intake and fat accumulation through de novo lipogenesis and acts to maintain a steady-state fat level in rodents.

Academic Significance and Societal Importance of the Research Achievements

我々は、他の研究グループが発見した既知の脳因子に関する研究ではなく、自らが発見した新規の脳因子NPGLに関する研究を推進し、極めて学術的独自性と創造性が高い成果を得ることができた。本来、脂肪蓄積は飢餓に備えた自己防御機構の一つである。脂肪組織でのde novo脂肪合成は糖代謝の改善等の報告が最近なされ始めており、NPGLによる脂肪組織のde novo脂肪合成制御は、我々ヒトの生活習慣病改善に役立つ可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018 2017

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] カリフォルニア大学バークレー校(米国)2017

    • Year and Date
      2017-02-24
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Neurosecretory protein GL induces fat accumulation in mice.2020

    • Author(s)
      Shikano K, Iwakoshi-Ukena E, Saito T, Narimatsu Y, Kadota A, Furumitsu M, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      J. Endocrinol.

      Volume: 244 Issue: 1 Pages: 1-12

    • DOI

      10.1530/joe-19-0112

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neurosecretory protein GL induces fat accumulation in chicks.2019

    • Author(s)
      Shikano K, Iwakoshi-Ukena E, Kato M, Furumitsu M, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      Front. Endocrinol.

      Volume: 10 Pages: 392-392

    • DOI

      10.3389/fendo.2019.00392

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Avian and murine neurosecretory protein GL participates in the regulation of feeding and energy metabolism2018

    • Author(s)
      Ukena Kazuyoshi
    • Journal Title

      General and Comparative Endocrinology

      Volume: 260 Pages: 164-170

    • DOI

      10.1016/j.ygcen.2017.09.019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks.2018

    • Author(s)
      Shikano K, Kato M, Iwakoshi-Ukena E, Furumitsu M, Matsuura D, Masuda K, Tachibana T, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      Gen Comp Endocrinol.

      Volume: 256 Pages: 37-42

    • DOI

      10.1016/j.ygcen.2017.05.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chronic subcutaneous infusion of neurosecretory protein GM increases body mass gain in chicks.2018

    • Author(s)
      Shikano K, Taniuchi S, Iwakoshi-Ukena E, Furumitsu M, Bentley GE, Kriegsfeld LJ and Ukena K.
    • Journal Title

      General and Comparative Endocrinology

      Volume: In press Pages: 71-76

    • DOI

      10.1016/j.ygcen.2017.11.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Localization and function of neurosecretory protein GM, a novel small secretory protein, in the chicken hypothalamus.2018

    • Author(s)
      Shikano K, Bessho Y, Kato M, Iwakoshi-Ukena E, Taniuchi S, Furumitsu M, Tachibana T, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 704-704

    • DOI

      10.1038/s41598-017-18822-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.2017

    • Author(s)
      Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K.
    • Journal Title

      Elife.

      Volume: 6

    • DOI

      10.7554/elife.28527

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurosecretory protein GL, a hypothalamic small secretory protein, participates in energy homeostasis in male mice2017

    • Author(s)
      Matsuura D*, Shikano K*, Saito T*, Iwakoshi-Ukena E, Furumitsu M, Ochi Y, Sato M, Bentley GE, Kriegsfeld LJ, Ukena K
    • Journal Title

      Endocrinology

      Volume: 158 Issue: 5 Pages: 1120-1129

    • DOI

      10.1210/en.2017-00064

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Neurosecretory protein GL, a novel hypothalamic small protein, participates in the regulation of feeding and energy homeostasis in birds and rodents2019

    • Author(s)
      Ukena K
    • Organizer
      The 5th Meeting of the Japan Branch of International Neuropeptide Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新規視床下部因子によるエネルギー代謝調節 ―脳と食欲・脂肪・筋肉との関係に着目して―2019

    • Author(s)
      浮穴和義
    • Organizer
      第27回日本運動生理学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Identification and function of two novel small secretory proteins, neurosecretory protein GL and neurosecretory protein GM, in the chicken hypothalamus2018

    • Author(s)
      Ukena K, Shikano K, Kato M, Furumitsu M, Iwakoshi-Ukena E
    • Organizer
      8th Intercongress of the AOSCE
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規脳因子の生理機能解析と今後の課題2018

    • Author(s)
      浮穴 和義
    • Organizer
      第9回ペプチド・ホルモン研究会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2016-10-04   Modified: 2021-02-19  

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