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Basic resarch for the diagnosis of the severity of brain injury after hypoxic ischemic insult by measuring changes in cerebral hemodynamic and EEG (Fostering Joint International Research)

Research Project

Project/Area Number 15KK0311
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

Nakamura Shinji  香川大学, 医学部附属病院, 助教 (30437686)

Research Collaborator Wong Flora  Monash University, The Richie Centre, 准教授
Walker David  
Project Period (FY) 2015 – 2018
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords早産児 / 神経血管反応 / 近赤外分光装置 / NIRS / 早産羊 / 胎児羊 / 感覚野 / 神経血管カップリング / 胎児 / 大脳皮質感覚野 / 体性感覚誘発電位 / 低酸素
Outline of Final Research Achievements

In the fetuses, 1.8s stimulation always increased delta-oxyHb in the contralateral cortex, whereas prolonged stimulations mostly produced transient or sustained decrease in delta-oxyHb (4.8s: 83%; 7.8s: 86% of all stimulations). In contrast, in neonatal lambs, 7.8s stimulation mostly produced increase in contralateral delta-oxyHb (71% of all stimulations). The SEP pattern was unaltered by duration of stimuli.
Conclusions: Prolonged somatosensory stimulation induced decreased cerebral oxygenation in the fetal brain, but increased cerebral oxygenation in the neonatal brain. Our results suggest immature NVC in the fetal brain, where oxygen delivery may not match the increased cerebral oxygen consumption that occurs with neural activation.

Academic Significance and Societal Importance of the Research Achievements

本研究結果より、子宮内の低酸素負荷などにより、感覚野における機能的発達過程が影響され、その後、子宮外に出ることで、早産児は過度の刺激に反応してしまい、脳の血管が異常な機能的発達を遂げ、後の発達障害などにつながっていくことが予想される。これらの仮説が明らかとなることで、早産児の発達障害の原因究明につながり、早期のリハビリテーション介入、父母の愛着形成のためのタッチングなどの早期治療へ発展できることが期待される。また、本研究で使用された脳波と近赤外分光装置を用いた、簡便で非侵襲的な神経血管カップリング評価方法が、早産児へ臨床応用されることが期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Int'l Joint Research] The Ritchie Centre, Hudson Institute of Medical Research(オーストラリア)2016

    • Year and Date
      2016-04-01
    • Related Report
      2018 Annual Research Report
  • [Journal Article] 1)Measurement of the Absolute Value of Cerebral Blood Volume and Optical Properties in Term Neonates Immediately after Birth Using Near-Infrared Time-Resolved Spectroscopy:A Preliminary Observation Study2019

    • Author(s)
      Morimoto A, Nakamura S, Sugino M et al.
    • Journal Title

      Appl Sci

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model2019

    • Author(s)
      Htun Yinmon、Nakamura Shinji、Nakao Yasuhiro、Mitsuie Tsutomu、Nakamura Makoto、Yamato Satoshi、Jinnai Wataru、Koyano Kosuke、Ohta Kenichi、Morimoto Aya、Wakabayashi Takayuki、Sugino Masashiro、Fujioka Kazumichi、Kato Ikuko、Kondo Sonoko、Yasuda Saneyuki、Miki Takanori、Ueno Masaki、Kusaka Takashi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 4088-4088

    • DOI

      10.1038/s41598-019-40674-8

    • NAID

      120006599245

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3)Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.2018

    • Author(s)
      Brew N, Nakamura S, Hale N et al.
    • Journal Title

      Pediatr Res

      Volume: 83 Issue: 3 Pages: 442-50

    • DOI

      10.1038/s41390-018-0045-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.2018

    • Author(s)
      Jinnai W, Nakamura S, Koyano K, Yamato S, Wakabayashi T, Htun Y, Nakao Y, Iwase T, Nakamura M, Yasuda S, Ueno M, Miki T, Kusaka T
    • Journal Title

      Brain Dev

      Volume: 40 Issue: 8 Pages: 649-661

    • DOI

      10.1016/j.braindev.2018.04.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebral haemodynamic response to somatosensory stimulation in newborn lamb.2017

    • Author(s)
      Nakamura S, Walker DW, Wong FY.
    • Journal Title

      J Physiol

      Volume: 595 Issue: 17 Pages: 60076021-60076021

    • DOI

      10.1113/jp274244

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep2017

    • Author(s)
      1.Nakamura S, Walker D.W., Wong F.Y.
    • Journal Title

      J Physiol

      Volume: 595 Issue: 4 Pages: 1289-1303

    • DOI

      10.1113/jp273163

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 胎児羊と新生仔羊におけるNeurovascular couplingの発達的変化について.2019

    • Author(s)
      中村 信嗣、 日下 隆、Flora Wong
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of hydrogen ventilation on aEEG findings in neonatal hypoxia-ischemia piglets.2019

    • Author(s)
      Htun Y, Nakamura S et al
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 出生後30分以内に脳障害重症度判定は可能か? 新生仔豚を用いた基礎的検討2019

    • Author(s)
      中尾 泰浩、中村 信嗣
    • Organizer
      第2回新生児基礎・トランスレーショナルリサーチ研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新生児低酸素性虚血性脳症における新規重症度判定法・治療の確立 新生仔豚を用いた水素ガス研究から2019

    • Author(s)
      中村 信嗣
    • Organizer
      東北大学病院総合周産期母子医療センター 新生児科指導医養成事業 第13回新生児科指導医教育セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新生仔豚仮死モデルにおける水素ガス吸入療法による脳保護効果について2019

    • Author(s)
      中村 信嗣
    • Organizer
      平成30年度文部科学省新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児羊大脳皮質感覚野における脳循環の機能的発達変化について2018

    • Author(s)
      中村 信嗣
    • Organizer
      第21回日本光機能イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Impact of the delivery modes on cerebral hemodynamic patterns in term neonates during immediate transition period using near-infrared time- resolved spectroscopy.2018

    • Author(s)
      Morimoto Aya, Nakamura S et al.
    • Organizer
      fNIRS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新生仔豚仮死モデルにおける水素ガス吸入療法による神経学的予後改善効果について.2018

    • Author(s)
      中村 信嗣、 Htun Yinmon
    • Organizer
      第8回日本分子状水素医学生物学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hydrogen Inhalation improved Motor Function in Neonatal Hypoxic Ischemic Piglet Model.2018

    • Author(s)
      Htun Y, Nakamura S et al
    • Organizer
      第54回日本周産期・新生児医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分娩形式は出生直後の新生児・脳循環酸素代謝変化にどのように影響を与えるか? 近赤外光時間分解分光装置(TRS)を用いた出生直後からの脳血液量モニタリング2018

    • Author(s)
      森本絢, 中村信嗣
    • Organizer
      第21回日本光機能イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effectiveness of Hydrogen in post hypoxic-ischemic neonatal piglets.2018

    • Author(s)
      Htun Y, Nakamura S et al
    • Organizer
      第21回日本光機能イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effectiveness of Hydrogen Inhalation in Neonatal Hypoxic-ischemic Piglet Model2018

    • Author(s)
      Htun Y, Nakamura S et al
    • Organizer
      Pediatric Academic Societies Meeting in Toronto 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] evelopment of neurovascular coupling in somatosensory cortex of fetal sheep and newborn lamb2016

    • Author(s)
      Shinji Nakamura
    • Organizer
      20th Annual conference of Perinatal Soceity of Australia and New Zealand
    • Place of Presentation
      Townsvile, Australia
    • Year and Date
      2016-05-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-10-04   Modified: 2020-03-30  

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