Single neuron discrimination for refining neural circuits(Fostering Joint International Research)
| Project/Area Number |
15KK0331
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Gunma University |
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Principal Investigator |
Kaneko Ryosuke 群馬大学, 大学院医学系研究科, 助教 (40390695)
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| Project Period (FY) |
2016 – 2019
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | プロトカドヘリン / 小脳 / 運動学習 / 遺伝子改変マウス / オランダ / 神経科学 / 回路形成 / 学習 |
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| Outline of Final Research Achievements |
In this study, the mouse cerebellum was used as a model system to verify the hypothesis that two neurons expressing the same Pcdh wire each other and make neural circuits. We found that Pcdh deficiency caused (i) abnormal cerebellar neural circuits in cerebellum and (ii) motor learning deficits. These results indicate that Pcdh is involved in the formation of functional neuronal circuits in the cerebellum. Furthermore, we have generated a Pcdh-expression reporter mouse, which will contribute to directly verify the hypothesis in the near future.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、小脳の機能的神経回路形成にPcdhが関与することが明らかとなった。小脳は運動学習を制御することが知られていた。さらに、近年になって自閉症への関与も報告され、高度な精神機能への関与も明らかとなった。従って、本研究を発展させることで、運動学習や高度な精神機能を担う新たな分子メカニズムの解明が予想される。将来的には、運動機能を向上させる新規な手法や自閉症の新たな治療法の開発に結びつく可能性がある。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Pcdhb deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination2020
Author(s)
Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu S, Yagi T, Inokuchi K
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Journal Title
Molecular Brain
Volume: 13
Pages: 7-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Targeted expression of step-function opsins in transgcnic rats for optogenetic studies.2018
Author(s)
Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 5435-5435
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.2016
Author(s)
Hasegawa S, Kumagai M, Hagiwara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T
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Journal Title
Front Mol Neurosci.
Volume: 9
Pages: 155-155
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.2016
Author(s)
Tarusawa E, Sanbo M, Okayama A, Miyashita T, Kitsukawa T, Hirayama T, Hirabayashi T, Hasegawa S, Kaneko R, Toyoda S, Kobayashi T, Kato-Itoh M, Nakauchi H, Hirabayashi M, Yagi T, Yoshimura Y.
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Journal Title
BMC Biol.
Volume: 14
Pages: 103-103
Related Report
Peer Reviewed / Open Access
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