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Genetic and Epigenetic Dysregulation in Cancer

Research Project

Project/Area Number 16059101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionJapanese Foundation For Cancer Research (2005-2009)
Tohoku University (2004)

Principal Investigator

NODA Tetsuo  Japanese Foundation For Cancer Research, 癌研究所, 所長 (10183550)

Co-Investigator(Kenkyū-buntansha) TAYA Youichi  国立がんセンター, 研究所 (60133641)
石川 冬木  京都大学, 大学院・生命科学研究科, 教授 (30184493)
花岡 文雄  学習院大学, 理学部, 教授 (50012670)
山本 雅之  東北大学, 大学院・医学系研究科, 教授 (50166823)
下遠野 邦忠 (下遠野 忠邦)  慶應義塾大学, 医学部・総合医科学研究センター, 教授 (10000259)
中村 卓郎  財団法人癌研究会, 癌研究所発がん研究部, 部長 (00180373)
Co-Investigator(Renkei-kenkyūsha) ISHIKAWA Fuyuki  京都大学, 生命科学研究科 (30184493)
HANAOKA Fumio  学習院大学, 理学部, 教授 (50012670)
YAMAMOTO Masayuki  東北大学, 医学系研究科 (50166823)
HATAKEYAMA Masanori  東京大学, 大学院・医学系研究科 (40189551)
NAKAMURA Takuro  財団法人癌研究会, 癌研究所 (00180373)
TAKAI Yoshimi  神戸大学, 医学研究科 (60093514)
NIWA Ohtsura  放射線医学研究所, 重粒子医科学センター (80093293)
HIROHASHI Setsuo  国立がんセンター (70129625)
SHIMOTONO Kunitada  千葉工業大学, 附属総合研究所 (10000259)
SAYA Hideyuki  慶應義塾大学, 医学部 (80264282)
Project Period (FY) 2004 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥27,900,000 (Direct Cost: ¥27,900,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2006: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2005: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywords遺伝学 / ウイルス / 癌 / ゲノム / 細胞・組織 / 遺伝子 / 細胞組織 / ウィルス
Research Abstract

The research area for "Genetic and Epigenetic Dysregulation in Cancer" was organized to elucidate the molecular mechanisms for the process of cancer initiation and progression. This board for the research consists of section chiefs and leading investigators in this area and has been working to promote research activities of principle investigators through varied types of activity, such as the organization of researchers and the evaluation of their activities. We also organized workshops to promote information exchange among investigators. Our activity has substantially contributed for the promotion of research activity and the production of many novel scientific findings by investigators in the area.

Report

(7 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (113 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (109 results) (of which Peer Reviewed: 49 results) Remarks (4 results)

  • [Journal Article] Structure and mechanism of human DNA polymeraseη2010

    • Author(s)
      C. Biertumpfel, Y. Zhao, Y. Kondo, S. Ramon-Maiques, M. Gregory, J.Y. Lee, C. Masutani, A.R. Lehmann, F. Hanaoka, W. Yang
    • Journal Title

      Nature 465

      Pages: 1044-1049

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p622010

    • Author(s)
      M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y-S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, S. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
    • Journal Title

      Nat. Cell Biol. 12

      Pages: 213-223

    • Related Report
      2009 Final Research Report
  • [Journal Article] Significance of PGP9. 5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma2010

    • Author(s)
      Y. Akishima-Fukasawa, Y. Ino, Y. Nakanishi, A. Miura, Y. Moriya, T. Kondo, Y. Kanai, S. Hirohashi
    • Journal Title

      Am. J. Clin. Pathol. 134

      Pages: 71-79

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling2010

    • Author(s)
      S.Hirono, T.Noda et.al.(total 13, last)
    • Journal Title

      Cancer Sci. 101

      Pages: 259-266

    • NAID

      10027200498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer : Increased expression of interferon-stimulated gene 15kd is associated with intrinsic chemoresistance2010

    • Author(s)
      S.Ina, T.Noda et.al.(total 4, 3rd)
    • Journal Title

      Pancreas 39

      Pages: 473-485

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1/ FoxO1 pathway in POMC neurons regulates Pomc expression and food intake2010

    • Author(s)
      K.Iskandar, T.Noda et.al.(total 14, 12th)
    • Journal Title

      Am.J.Physiol.Endocrinol.Metab. 298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SDOP-DB : A comparative standardised-protocol database for mouse phenotypic analyses2010

    • Author(s)
      N.Tanaka, T.Noda et.al.(total 18, 12th)
    • Journal Title

      Bioinformatics 26

      Pages: 1133-1134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice2010

    • Author(s)
      H.Sato, T.Noda et.al.(total 15, 14th)
    • Journal Title

      Mol.Vis. 16

      Pages: 378-391

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotypic characterization of a new Grinl mutant mouse generated by ENU mutagenesis2010

    • Author(s)
      T.Furuse, T.Noda et.al.(total 20, 18th)
    • Journal Title

      Eur.J.Neurosci. 31

      Pages: 1281-1291

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory activity of PYNOD and its mechanism in humans and mice2010

    • Author(s)
      R.Inamura, T.Noda et.al.(total 9, 5th)
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway2009

    • Author(s)
      Y. Miyake, M. Nakamura, A. Nabetani, S. Shimamura, M. Tamura, S. Yonehara, M. Saito, F. Ishikawa
    • Journal Title

      Mol. Cell 36

      Pages: 193-206

    • Related Report
      2009 Final Research Report
  • [Journal Article] Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma2009

    • Author(s)
      T. Yamanashi, Y. Nakanishi, G. Fujii, Y. Akishima-Fukasawa, Y. Moriya, Y. Kanai, M. Watanabe, S. Hirohashi
    • Journal Title

      Oncology. 77

      Pages: 53-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection2009

    • Author(s)
      B.N.Benoit, T.Noda et.al.(total 12, 9th)
    • Journal Title

      J.Histochem.Cytochem. 57

      Pages: 327-338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via Nuclear Factor-κB activation2009

    • Author(s)
      H.Tanaka, T.Noda et.al.(total 9, 6th)
    • Journal Title

      Mol.Cancer Res. 7

      Pages: 557-569

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways2009

    • Author(s)
      T.Watanabe, T.Noda et.al.(total 19, 14th)
    • Journal Title

      J.Biol.Chem. 284

      Pages: 1803-1812

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint2009

    • Author(s)
      K.S.Uchida, T.Noda et.al.(total 6, 5th)
    • Journal Title

      J.Cell Biol. 184

      Pages: 383-390

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms2009

    • Author(s)
      T.Hirose, T.Noda et.al.(total 10, 9th)
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 coordinates survival pathways and{beta}-adrenergic response in the heart2009

    • Author(s)
      K.Ito, T.Noda et.al.(total 15, 13th)
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 8689-8694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles2009

    • Author(s)
      P.Reddy, T.Noda et.al.(total 11, 8th)
    • Journal Title

      Hum.Mol.Genet. 18

      Pages: 2813-2824

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009

    • Author(s)
      H.Shibata, T.Noda et.al.(total 12, 11th)
    • Journal Title

      Cancer Sci. 100

      Pages: 956-960

    • NAID

      10025146044

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation2009

    • Author(s)
      G.Martinez, T.Noda et.al.(total 8, 6th)
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 50

      Pages: 4794-4806

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oocyte activation ability correlates with head flatness and presence of perinuclear theca substance in human and mouse sperm2009

    • Author(s)
      C.Ito, T.Noda et.al.(total 9, 8th)
    • Journal Title

      Hum.Reprod. 24

      Pages: 2588-2595

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium2009

    • Author(s)
      H.Mutai, T.Noda et.al.(total 6, 4th)
    • Journal Title

      Dev.Neurobiol. 69

      Pages: 913-930

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introduction to the Japan mouse clinic at the RIKEN BioResource center2009

    • Author(s)
      S.Wakana, T.Noda et.al.(total 16, 12th)
    • Journal Title

      Exp.Anim. 58

      Pages: 443-450

    • NAID

      130000122254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via Nuclear Factor-B activation.2009

    • Author(s)
      H. Tanaka, T. Noda, et. al. (total 9, 6th)
    • Journal Title

      Mol. Cancer Res. 7

      Pages: 557-569

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.2009

    • Author(s)
      T. Watanabe, T. Noda, et. al. (total 19, 14th)
    • Journal Title

      J. Biol. Chem. 284

      Pages: 1803-1812

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetochore stretching inactivates the spindle assembly checkpoint.2009

    • Author(s)
      K. S. Uchida, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      J. Cell Biol. 184

      Pages: 383-390

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKC1ambda, on the maintenance of podocyte slit diaphragms.2009

    • Author(s)
      T. Hirose, T. Noda, et. al. (total 1O, 9th)
    • Journal Title

      PLoS ONE 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 coordinates survival pathways and {beta}-adrenergic response in the heart.2009

    • Author(s)
      K. Ito, T. Noda, et. al. (total 15, 13th)
    • Journal Title

      Proc. Natl. Acad. Sci. USA

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.2009

    • Author(s)
      P. Reddy, T. Noda, et. al. (tota111,8th)
    • Journal Title

      Hum. Mol. Genet.

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length2008

    • Author(s)
      T. Miyoshi, J. Kanoh, M. Saito, F. Ishikawa
    • Journal Title

      Science 320

      Pages: 1341-1344

    • Related Report
      2009 Final Research Report
  • [Journal Article] GATA1-related leukaemias2008

    • Author(s)
      R. Shimizu, J.D. Engel, M. Yamamoto
    • Journal Title

      Nat. Rev. Cancer 8

      Pages: 279-287

    • Related Report
      2009 Final Research Report
  • [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse2008

    • Author(s)
      N. Ohnishi, H. Yuasa, S. Tanaka, H. Sawa, M. Miura, A. Matsui, H. Higashi, M. Musashi, K. wabuchi, M. Suzuki, G. Yamada, T. Azuma, M. Hatakeyama
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 1003-1008

    • Related Report
      2009 Final Research Report
  • [Journal Article] Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation2008

    • Author(s)
      Y. Takai, J. Miyoshi, W. Ikeda, H. Ogita
    • Journal Title

      Nat. Rev. Mol. Cell Biol. 9

      Pages: 603-615

    • Related Report
      2009 Final Research Report
  • [Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice2008

    • Author(s)
      D. Zhang, T. Shimizu, N. Araki, T. Hirota, M. Yoshie, K. Ogawa, N. Nakagata, M. Takeya, H. Saya
    • Journal Title

      Oncogene 27

      Pages: 4305-4314

    • Related Report
      2009 Final Research Report
  • [Journal Article] Megaintestine in claudin-15-deficient mice.2008

    • Author(s)
      A. Tamura, T. Noda, et. al. (total 12, 9th)
    • Journal Title

      Gastroenterology 134

      Pages: 523-534

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GTAssist : An evaluation tool for efficient selection of SNP markersin large-scale genotyping.2008

    • Author(s)
      E. Kaminuma, T. Noda, et. al.(total 12, 9th)
    • Journal Title

      J. Bioinform. Comput. Biol. 6

      Pages: 905-917

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic response of pancreatic beta-cell mass to ablation of TSC2 in mice.2008

    • Author(s)
      Y. Shigeyama, T. Noda, et. al. (total 15, 15th)
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 2971-2979

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoporptic bone formation in mice lacking tob2 ; involvement of Tob2 in RANK Iigand expression and osteoclasts differentiation.2008

    • Author(s)
      A. Ajima, T. Noba, et. al. (total 11, 10th)
    • Journal Title

      FEBS Lett. 582

      Pages: 1313-1318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Z0-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apotosis of embryonic cells.2008

    • Author(s)
      T. Katsuno, T. Noda, et. al. (total 12, 10th)
    • Journal Title

      Mol. Biol. Cell 19

      Pages: 2465-2475

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.2008

    • Author(s)
      W. Yano, T. Noda, et. al.(total 14, 11th)
    • Journal Title

      Endocr. J. 55

      Pages: 515-522

    • NAID

      10021266439

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDKl regulates cell proliferation and cell cycle progression through control of cyclin Dl and p27Kipl expression.2008

    • Author(s)
      K. Nakamura, T. Noda, et. al.(total 12, 10th)
    • Journal Title

      J. Biol. Chem. 283

      Pages: 17702-17711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hapatic insulin sighaling during fasting and feeding.2008

    • Author(s)
      N. Kubota, T. Noda, et. al. (total 21, 15th)
    • Journal Title

      Cell Metab. 8

      Pages: 49-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HOXB2, an adverse prognostic indicator for stage I lung adenocarcinomas, promotes invasion by transcriptional regulation of metastasis-related genes in HOP-62 non-small cell lung cancer cells.2008

    • Author(s)
      H. Inamura, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      Anticancer Res. 28

      Pages: 2121-2128

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis.2008

    • Author(s)
      M. Isomura, T. Noda, et. al. (total 20, 9th)
    • Journal Title

      Clin. Cancer Res. 14

      Pages: 6683-6689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008

    • Author(s)
      Y. Dohi, T. Noda, et. al. (total 13, 12th)
    • Journal Title

      Nat. Struct. Mol. Biol. 15

      Pages: 1246-1254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of new long conserved noncoding sequences in vertebrates.2008

    • Author(s)
      Y. Sakuraba, T. Noda, et. al. (total 15, 13th)
    • Journal Title

      Mamm. Genome 19

      Pages: 703-712

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice.2008

    • Author(s)
      A. Takeda, T. Noda, et. al. (total 6, 5th)
    • Journal Title

      Kobe J. Med. Sci. 54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection.2008

    • Author(s)
      B. N. Benoit, T. Noda, et. al. (total 12, 9th)
    • Journal Title

      J. Histochem. Cytochem. 57

      Pages: 327-338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fission yeast Potl-Tppl protects telomeres and regulates telomere length via novel effectors.2008

    • Author(s)
      T. Miyoshi, F. Ishikawa, et. al. (total 4, last)
    • Journal Title

      Science (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA1-related leukemias.2008

    • Author(s)
      R. Shimizu, M. Yamamoto, et. al. (total 3, last)
    • Journal Title

      Nat. Rev. Cancer 8

      Pages: 279-287

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tribl and Evil cooperate with Hoxa and Meisl in myeloid leukemogenesis.2008

    • Author(s)
      G. JIn, T. Nakamura, et. al. (total 8, last)
    • Journal Title

      Blood 109

      Pages: 3998-4005

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of clathrin-mediated endocytosis by p53.2008

    • Author(s)
      Y. Endo, Y. Taya, et. al. (total 10, last)
    • Journal Title

      Genes Cells 13

      Pages: 375-386

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation induction of delayed recombination in Schizosaccharomyces pombe.2008

    • Author(s)
      J. Takeda, 0. Niwa, et. al. (total 6, last)
    • Journal Title

      DNA Repair (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Catenin is essential in intestinal adenoma formation2007

    • Author(s)
      H. Shibata, H. Takano, M. Ito, H. Shioya, M. Hirota, H. Matsumoto, Y. Kakudo, C. Ishioka, T. Akiyama, Y. Kanegae, I. Saito, T. Noda.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 18199-18204

    • Related Report
      2009 Final Research Report
  • [Journal Article] TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton2007

    • Author(s)
      R. Yao, Y. Natsume, T. Noda
    • Journal Title

      Cancer Sci. 98

      Pages: 555-562

    • Related Report
      2009 Final Research Report
  • [Journal Article] Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity2007

    • Author(s)
      I. Saadat, H. Higashi, C. Obuse, M. Umeda, N. Murata-Kamiya, Y. Saito, H. Lu, N. Ohnishi, T. Azuma, A. Suzuki, S. Ohno, M. Hatakeyama
    • Journal Title

      Nature 447

      Pages: 330-333

    • Related Report
      2009 Final Research Report
  • [Journal Article] Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis2007

    • Author(s)
      G. Jin, Y. Yamazaki, M. Takuwa, T. Takahara, K. Kaneko, T. Kuwata, S. Miyata, T. Nakamura
    • Journal Title

      Blood 109

      Pages: 3998-4005

    • Related Report
      2009 Final Research Report
  • [Journal Article] The lipid droplet is an important organelle for hepatitis Cvirus production2007

    • Author(s)
      Y. Miyanri, K. Atsuzawa, N. Usuda, K. Watashi, T. Hishiki, M. Zayas, R. Bartenschlager, T. Wakita, M. Hijikata, K. Shimotohno
    • Journal Title

      Nat. Cell Biol. 9

      Pages: 1089-1097

    • Related Report
      2009 Final Research Report
  • [Journal Article] α-Catenin is essential in intestinal adenoma formation.2007

    • Author(s)
      H. Shibata, T. Noda, et. al. (total 12, last)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 18199-18204

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the human GINS complex and its assembly and functional interface in replication initiation.2007

    • Author(s)
      K. Kamada, F. Hanaoka, et. al. (total 5, last)
    • Journal Title

      Nature Struct. Mol. Biol. 14

      Pages: 388-396

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The lipid droplet is an important organelle for hepatitis Cvirus production.2007

    • Author(s)
      Y. Miyanari, K. Shimotohno, et. al. (total 10, last)
    • Journal Title

      Nat. Cell Biol. 9

      Pages: 1089-9710

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.2007

    • Author(s)
      S. Nakata, Y. Takai, et. al. (total 6, last)
    • Journal Title

      J. Biol. Chem. 282

      Pages: 37815-37825

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.2007

    • Author(s)
      H. Katoh, S. Hirohashi, et. al. (total 11, 10th)
    • Journal Title

      Gastroenterology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tacc3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton.2007

    • Author(s)
      R.Yao, T.Noda et al.(total 3, last)
    • Journal Title

      Cancer Science 98(4)

      Pages: 555-562

    • Related Report
      2006 Annual Research Report
  • [Journal Article] p21 provides stage specific DNA damage control to preimplantation embryos.2007

    • Author(s)
      S.K.Adiga, O.Niwa et al.(total 9, last)
    • Journal Title

      Oncogene 2007 (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of Linker Histone H1 in Cellular Senescence.2006

    • Author(s)
      R.Funayama, F.Ishikawa et al.(total 4, last)
    • Journal Title

      J. Cell Biol. 175(6)

      Pages: 869-880

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Negative regulation of condensin I by CK2 phosphorylation during interphase.2006

    • Author(s)
      A.Takemoto, F.Hanaoka et al.(total 5, last)
    • Journal Title

      EMBO J. 25(22)

      Pages: 5339-5348

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural basis for defects of Keapl activity provoked by its point mutations in lung cancer.2006

    • Author(s)
      B.Padmanabhan, M.Yamamoto et al.(total 10, last)
    • Journal Title

      Mol. Cell 21(5)

      Pages: 689-700

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Diverse effects of cyclosporine on hepatitis C virus strain replication.2006

    • Author(s)
      N.Ishii, K.Shimotohno et al.(total 9, last)
    • Journal Title

      J Virol. 80(9)

      Pages: 4510-4520

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4; 19)(q35;q13) translocation.2006

    • Author(s)
      M.Kawamura-Saito, T.Nakamura et al.(total 12, last)
    • Journal Title

      Hum. Mol. Genet. 15(13)

      Pages: 2125-2137

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Requirement of clathrin heavy chain for p53-mediated transcription.2006

    • Author(s)
      M.Enari, Y.Taya et al.(total 4, last)
    • Journal Title

      Genes Dev. 20(9)

      Pages: 1087-1099

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interaction of integrin avb3 with nectin : implication in cross-talk between cell-matrix and cell-cell junctions.2006

    • Author(s)
      Y.Sakamoto, Y.Takai et al.(total 9, last)
    • Journal Title

      J. Biol. Chem. 281(28)

      Pages: 19631-19644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics2006

    • Author(s)
      T.Kondo, S.Hirohashi
    • Journal Title

      Nature Protocols 1(6)

      Pages: 2940-2956

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The selective continued linkage of centromeres through mitosis to interphase in the absence of mammalian separase.2006

    • Author(s)
      K.Kumada, T.Noda et al.(total 12, last)
    • Journal Title

      J.Cell Biol. 121(3)

      Pages: 835-846

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase.2006

    • Author(s)
      A.Nishiyama, F.Ishikawa et al.(total 6, last)
    • Journal Title

      EMBO J. 25(3)

      Pages: 575-584

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer.2006

    • Author(s)
      B.Padmanabhan, M.Yamamoto et al.(total 10, last)
    • Journal Title

      Mol.Cell 21(5)

      Pages: 1-12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Requirement of clathrin heavy chain for p53-mediated transcription.2006

    • Author(s)
      M.Enari, Y.Taya et al.(total 4, last)
    • Journal Title

      Genes Dev. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex2005

    • Author(s)
      K. Sugasawa, Y. Okuda, M. Saijo, R. Nishi, N. Matsuda, G. Chu, T. Mori, S. Iwai, K. Tanaka, K. Tanaka, F. Hanaoka
    • Journal Title

      Cell 121

      Pages: 387-400

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Nec1-5 with nectin-32005

    • Author(s)
      T. Fujito, W. Ikeda, S. Kakunaga, Y. Minami, M. Kajita, Y. Sakamoto, M. Monden, Y. Takai
    • Journal Title

      J. Cell Biol. 171

      Pages: 165-173

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase2005

    • Author(s)
      K. watashi, N. Ishii, M. Hijikata, D. Inoue, T. Murata, Y. Miyanari, K. Shimotohno
    • Journal Title

      Mol. Cell 19

      Pages: 111-122

    • Related Report
      2009 Final Research Report
  • [Journal Article] Aurora A - A guardian of poles2005

    • Author(s)
      T. Marumoto, D. Zhang, H. Saya
    • Journal Title

      Nat. Rev. Cancer 5

      Pages: 42-50

    • Related Report
      2009 Final Research Report
  • [Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.2005

    • Author(s)
      K.Sugasawa, F.Hanaoka et al.(total 10, last)
    • Journal Title

      Cell 121(3)

      Pages: 387-400

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.2005

    • Author(s)
      K.Watashi, K.Shimotohno et al.(total 7, last)
    • Journal Title

      Mol.Cell 19(1)

      Pages: 111-122

    • Related Report
      2005 Annual Research Report
  • [Journal Article] EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12).2005

    • Author(s)
      S.Yamaguchi, T.Nakamura et al.(total 6, last)
    • Journal Title

      Genes Chromosomes Cancer 43(2)

      Pages: 217-222

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.2005

    • Author(s)
      T.Fujito, Y.Takai et al.(total 8, last)
    • Journal Title

      J.Cell Biol. 171(1)

      Pages: 165-173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transcription independent suppression of DNA synthesis by p53 in sperm irradiated mouse zygotes.2005

    • Author(s)
      M.Toyoshima, O.Niwa et al.(total 8, last)
    • Journal Title

      Oncogene 24(20)

      Pages: 3229-3235

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis : its association with clinicopathological features.2005

    • Author(s)
      T.Shibata, S.Hirohashi et al.(total 13, last)
    • Journal Title

      Clinical Cancer Res. 11(17)

      Pages: 6177-6185

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oct-3/4 and sox2 regulate oct-3/4 gene in embryonic stem cells.2005

    • Author(s)
      F.Ishikawa.(他2名)
    • Journal Title

      J.Biol.Chem. 280(7)

      Pages: 5307-5317

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.2005

    • Author(s)
      T.Nakamura.(他8名)
    • Journal Title

      Blood 105(2)

      Pages: 784-793

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Retroviral insertional mutagenesis identifies oncogene cooperation.2005

    • Author(s)
      T.Nakamura.
    • Journal Title

      Cancer Sci. 96(1)

      Pages: 7-12

    • NAID

      10015523673

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transcriptional induces p53-dependent apoptosis associated with translocation of p53 to mithochondria.2005

    • Author(s)
      Y.Taya.(他7名)
    • Journal Title

      J.Blol.Chem. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transcription independent suppression of DNA synthesis by p53 in sperm irradiated mouse zygotes.2005

    • Author(s)
      Niwa.O.(他7名)
    • Journal Title

      Oncogene Feb.14

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.2005

    • Author(s)
      S.Hirohashi.(他8名)
    • Journal Title

      Gastroenterology 128(1)

      Pages: 51-62

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking Cnot7,a regulator of retinoid X receptor beta.2004

    • Author(s)
      T.Noda.(他14名)
    • Journal Title

      Nature Genetics 36(5)

      Pages: 528-533

    • Related Report
      2004 Annual Research Report
  • [Journal Article] MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.2004

    • Author(s)
      T.Noda.(他14名)
    • Journal Title

      Oncogene 23(36)

      Pages: 6023-6030

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Localization of hRad9,hHus1,hRad1,and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promvelocytic leukemia body.2004

    • Author(s)
      F.Ishikawa.(他2名)
    • Journal Title

      J.Biol.Chem. 279(24)

      Pages: 25849-25857

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Localization of human Mcm10 is spatially and temporally regulated during S phase.2004

    • Author(s)
      F.Hanaoka.(他2名)
    • Journal Title

      J.Biol.Chem. 279(31)

      Pages: 32569-32577

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis.2004

    • Author(s)
      F.Hanaoka.(他4名)
    • Journal Title

      Genes Cells 9(12)

      Pages: 1139-1150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.2004

    • Author(s)
      M.Yamamoto.(他8名)
    • Journal Title

      Cancer Res. 64(18)

      Pages: 6124-6431

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Leukemogenesis caused by incapacitated GATA-1 function.2004

    • Author(s)
      M.Yamamoto.(他7名)
    • Journal Title

      Mol.Cell.Biol. 24(24)

      Pages: 10814-10825

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.2004

    • Author(s)
      K.Shimotohno.(他7名)
    • Journal Title

      Oncogene 23(45)

      Pages: 7593-7600

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The role of notch signaling in the development of intrahepatic bile ducts.2004

    • Author(s)
      K.Shimotohno(他4名)
    • Journal Title

      Gastroenterology 127(6)

      Pages: 1775-1786

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK signaling.2004

    • Author(s)
      Y.Takai.(他7名)
    • Journal Title

      J.Biol.Chem. 279(35)

      Pages: 36419-36423

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.2004

    • Author(s)
      Y.Takai.(他10名)
    • Journal Title

      J.Cell Blol. 166(3)

      Pages: 393-405

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinae-3β.2004

    • Author(s)
      Y.Taya.(他9名)
    • Journal Title

      Genes Dev. 18(3)

      Pages: 261-277

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Generation of multipotent stem cells from postnatal mouse testis.2004

    • Author(s)
      Niwa.O.(他17名)
    • Journal Title

      Cell 119(7)

      Pages: 1001-1012

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.2004

    • Author(s)
      S.Hirohashi.(他8名)
    • Journal Title

      Cancer Res. 64(19)

      Pages: 6989-6995

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis

    • Author(s)
      T. Yokoyama, Y. Kanno, Y. Yamazaki, T. Takahara, S. Miyata, T. Nakamura
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/index.html

    • Related Report
      2007 Annual Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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