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Disorganization of cell and tissue systems in cancer

Research Project

Project/Area Number 16060101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKobe University (2008-2009)
Osaka University (2004-2007)

Principal Investigator

TAKAI Yoshimi  Kobe University, 大学院・医学研究科, 教授 (60093514)

Co-Investigator(Kenkyū-buntansha) 秋山 徹  東京大学, 分子細胞生物学研究所, 教授 (70150745)
大野 茂男  横浜市立大学, 医学研究科, 教授 (10142027)
竹縄 忠臣  神戸大学, 医学系研究科, 教授 (40101315)
清木 元治  東京大学, 医科学研究所, 教授 (10154634)
高倉 伸幸  大阪大学, 微生物病研究所, 教授 (80291954)
月田 承一郎  京都大学, 医学研究科, 教授 (50155347)
Co-Investigator(Renkei-kenkyūsha) AKIYAMA Tetsu  東京大学, 分子細胞生物学研究所, 教授 (70150745)
OHNO Shigeo  横浜市立大学, 大学院・医学研究科, 教授 (10142027)
TSUKITA Shoichiro  京都大学, 大学院・医学研究科, 教授 (50155347)
TAKENAWA Tadaomi  神戸大学, 大学院・医学研究科, 教授 (40101315)
SEIKI Motoharu  東京大学, 医科学研究所, 教授 (10154634)
TAKAKURA Nobuyuki  大阪大学, 微生物病研究所, 教授 (80291954)
Project Period (FY) 2004 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥20,700,000 (Direct Cost: ¥20,700,000)
Fiscal Year 2009: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2008: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2007: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsがん / 細胞運動 / 細胞増殖 / 細胞接着 / 組織 / 増殖 / 細胞死 / 細胞極性 / 分化 / 浸潤 / 転移 / 浸潤・転移 / 接着 / 細胞外マトリックス
Research Abstract

A number of previous studies revealed the properties of cancer cells at the levels of genes and cells, contributing to the elucidation of the mechanisms by which cancer is a life-threatening disease. Based on accumulating lines of evidence concerning cancer cells, it was systematically investigated in this project how "the initiation and progression of cancer" are induced in terms of the disorganization of cell and tissue systems in cancer. It was found that abnormalities of cell movement, proliferation, and adhesion in cancer cells play important roles in this disorganization.

Report

(7 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (125 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (84 results) (of which Peer Reviewed: 48 results) Presentation (27 results) Book (2 results) Remarks (10 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.2010

    • Author(s)
      Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.
    • Journal Title

      Cancer Res. 70(3)

      Pages: 1215-1224

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adenomatous polyposis coil-associated guanine nucleotide exchange factor Asef is involved in anglogenesis.2010

    • Author(s)
      Y.Kawasaki
    • Journal Title

      J.Biol.Chem 285巻・2号

      Pages: 1199-1207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome of acidic phospholipid-binding proteins : Spatial and temporal reaulation of coronin 1A by phosphoinositides.2010

    • Author(s)
      K.Tsujita
    • Journal Title

      J.Biol.Chem. 285巻・9号

      Pages: 6781-6789

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.2010

    • Author(s)
      Y.Nagahama
    • Journal Title

      Cancer Res. 70巻・3号

      Pages: 1215-1224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin induces enlarged and non-leaky blood vessels for functional recovery from ischemia.2010

    • Author(s)
      H.Kidoya
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.2009

    • Author(s)
      Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, Hirata K, Takai Y.
    • Journal Title

      J Biol Chem. 284(36)

      Pages: 24595-24609

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice.2009

    • Author(s)
      Kawasaki Y, Tsuji S, Muroya K, Furukawa S, Shibata Y, Okuno M, Ohwada S, Akiyama T.
    • Journal Title

      EMBO Rep. 10(12)

      Pages: 1355-1362

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] aPKCλ/ιpromotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.2009

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H.
    • Journal Title

      Proc Natl Acad Sci USA. 106(38)

      Pages: 16369-16374

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.2009

    • Author(s)
      Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
    • Journal Title

      Sci Signal. 2(87)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKCλ, on the maintenance of podocyte slit diaphragms.2009

    • Author(s)
      Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S.
    • Journal Title

      PLoS One. 4(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27kip1 and regulates RhoA activation, actin remodeling, and Matrigel invasion.2009

    • Author(s)
      Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M.
    • Journal Title

      J Biol Chem. 284(40)

      Pages: 27315-27326

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration.2009

    • Author(s)
      Ueno M, Itoh M, Sugihara K, Asano M, Takakura N.
    • Journal Title

      Blood. 113(3)

      Pages: 555-562

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2.2009

    • Author(s)
      S.Kawano
    • Journal Title

      J.Biol.Chem. 284巻・35号

      Pages: 23793-23805

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G oroteins at leadina edges of moving NIH3T3 cells.2009

    • Author(s)
      M.Miyata
    • Journal Title

      J.Biol.Chem. 284巻・36号

      Pages: 24595-24609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc^<Mln/+> mice.2009

    • Author(s)
      Y.Kawasaki
    • Journal Title

      EMBO Rep. 10巻・12号

      Pages: 1355-1362

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence.2009

    • Author(s)
      R.Takagawa
    • Journal Title

      Ann.Surg.Oncol. 17巻・1号

      Pages: 81-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] aPKClambda/iota promotes growth of prostate cancer cells In an autocrine manner through transcriptional activation of interleukin-6.2009

    • Author(s)
      H.Ishiguro
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106巻・38号

      Pages: 16369-16374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The tyrosine kinase Far is a downstream target of the PLD=PLA pathway that reaulates cell miaration.2009

    • Author(s)
      T.Itoh
    • Journal Title

      Sci.Signal. 2巻・87号

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.2009

    • Author(s)
      D.Hoshino
    • Journal Title

      J.Biol.Chem. 284巻・40号

      Pages: 27315-27326

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1(MT1-MMP) : a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells2009

    • Author(s)
      D.Niiya
    • Journal Title

      J.Biol.Chem. 284巻・40号

      Pages: 27360-27369

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organizationand are involved in HGF-induced cell migration2009

    • Author(s)
      Sagara, M.
    • Journal Title

      Oncogene 28

      Pages: 1357-1365

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms2009

    • Author(s)
      Hirose, T.
    • Journal Title

      PLoS ON 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration2009

    • Author(s)
      Ueno, M
    • Journal Title

      Blood 113

      Pages: 55-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation.2008

    • Author(s)
      Takai Y, Miyoshi J, Ikeda W, Ogita H.
    • Journal Title

      Nat Rev Mol Cell Biol. 9(8)

      Pages: 603-615

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/ β-catenin complex.2008

    • Author(s)
      Nakamura T, Hayashi T, Nasu- Nishimura Y, Sakaue F, Morishita Y, Okabe T, Ohwada S, Matsuura K, Akiyama T.
    • Journal Title

      Genes Dev. 22(9)

      Pages: 1244-1256

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential signals toward podosome formation in NIH-src cells.2008

    • Author(s)
      Oikawa T, Itoh T, Takenawa T.
    • Journal Title

      J Cell Biol. 182(1)

      Pages: 157-169

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] he second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.2008

    • Author(s)
      Itoh Y, Ito N, Nagase H, Seiki M.
    • Journal Title

      J Biol Chem. 283(19)

      Pages: 13053-13062

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Necl-5/Poliovirus receptor and ROCK in the regulation of I transformation of integrin αvβ3-based focal complexes into focal adhesions2008

    • Author(s)
      Nagamatsu, Y.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 14532-14541

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nectins and nectin-like molecules : roles in contact inhibition of cell movement and proliferation2008

    • Author(s)
      Takai, Y.
    • Journal Title

      Nat. Rev. Mol. Cell Biol 9

      Pages: 603-615

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex2008

    • Author(s)
      Nakamura, T.
    • Journal Title

      Genes & Development 22

      Pages: 1244-1256

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential signals toward podosome formation in NIH-src cells2008

    • Author(s)
      Oikawa, T.
    • Journal Title

      J. Cell Biol. 182

      Pages: 157-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased insulin action in SKIP heterozygous knockout mice2008

    • Author(s)
      Ijuin, T.
    • Journal Title

      Mol. Cell Biol 28

      Pages: 5184-5195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface2008

    • Author(s)
      Ito, Y.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 13053-13062

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype : a metastasis model cell line2008

    • Author(s)
      Imai, M.
    • Journal Title

      BMC Cancerm 8

      Pages: 319-328

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-12008

    • Author(s)
      Fukuhara, S.
    • Journal Title

      Nat Cell Biol 10

      Pages: 513-526

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necl-5/poliovirus receptor interacts in cis with integrin α_νβ_ε and regulates its clustering and focal complex formation.2007

    • Author(s)
      Minami, Y.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 18481-18496

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions.2007

    • Author(s)
      Ooshio, T.
    • Journal Title

      J. Cell Sci. 120

      Pages: 2352-2365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.2007

    • Author(s)
      Kawasaki, Y.
    • Journal Title

      Oncogene 26

      Pages: 7620-7627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarity-regulating kinase Par1β/MARK2 negatively regulates development of dendrites on hippocampal neurons.2007

    • Author(s)
      Terabayashi, T.
    • Journal Title

      J. Neurosci. 27

      Pages: 13098-13107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curved EFC/F-Bar domain dimmers are jointed end to end into a filament for membrane invagination in endocytosis.2007

    • Author(s)
      Shimada, A.
    • Journal Title

      Cell 129

      Pages: 761-772

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The WAVE2/Abil complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.2007

    • Author(s)
      Eto, K.
    • Journal Title

      Blood 110

      Pages: 3637-3647

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.2007

    • Author(s)
      Taniwaki, K.
    • Journal Title

      Cancer Res. 67

      Pages: 4311-4319

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.2007

    • Author(s)
      Yana, I.
    • Journal Title

      J. Cell Sci. 120

      Pages: 1607-1614

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EphB4 overexpression on B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis.2007

    • Author(s)
      Huang, X.
    • Journal Title

      Cancer Res. 67

      Pages: 9800-9808

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.2007

    • Author(s)
      Yamazaki, D.
    • Journal Title

      J. Cell Sci. 120・1

      Pages: 86-100

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interaction of integrin α_vβ_3 with nectin : implication in cross-talk between cell-matrix and cell-cell junctions.2006

    • Author(s)
      Sakamoto, Y.
    • Journal Title

      J. Biol. Chem. 281・28

      Pages: 19631-19644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Requirement of nectin, but not cadherin, for formation of claudin-based tight junctions in annexin II-knockdown MDCK cells.2006

    • Author(s)
      Yamada, A.
    • Journal Title

      Oncogene 25・37

      Pages: 5085-5102

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.2006

    • Author(s)
      Takizawa, S.
    • Journal Title

      Genes Cells 11・4

      Pages: 453-464

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Wnt signalling and the actin cytoskeleton.2006

    • Author(s)
      Akiyama, T.
    • Journal Title

      Oncogene 25・57

      Pages: 7538-7544

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lgl mediates apical domain disassembly by suppressing PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.2006

    • Author(s)
      Yamanaka, T.
    • Journal Title

      J. Cell Science 119・10

      Pages: 2107-2118

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.2006

    • Author(s)
      Hirai, S.
    • Journal Title

      J. Neurosci. 26・46

      Pages: 11992-12002

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The RAC-binding domain/IRSP53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.2006

    • Author(s)
      Suetsugu, S.
    • Journal Title

      J. Biol. Chem. 281・46

      Pages: 35347-35358

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.2006

    • Author(s)
      Itoh, Y.
    • Journal Title

      Mol. Biol. Cell 17・12

      Pages: 5390-5399

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.2006

    • Author(s)
      Egawa, N.
    • Journal Title

      J Biol. Chem. 281・49

      Pages: 37576-37585

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Physiological pathway of differentiation of hematopoietic stem cell population into mural cells.2006

    • Author(s)
      Yamada, Y.
    • Journal Title

      J. Exp. Med. 203・4

      Pages: 1055-1065

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Negative regulation of VEGF-induced vascular leakage by blockade of angiotensin II type 1 receptor.2006

    • Author(s)
      Sano, H.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol. 26・12

      Pages: 2673-2680

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in MDCK cells.2006

    • Author(s)
      Sato, T.
    • Journal Title

      J.Biol.Chem. 281・8

      Pages: 5288-5299

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of the kinesin-2 family protein, KIF3, during mitosis.2006

    • Author(s)
      Haraguchi, K.
    • Journal Title

      J.Biol.Chem. 281・7

      Pages: 4049-4099

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Coordination between actin cytoskeleton and the membrane deformation by a novel membrane tubulation domain of the PCH proteins is involved in endocytosis.2006

    • Author(s)
      Tsujita, K.
    • Journal Title

      J.Cell Biol. 172・2

      Pages: 269-279

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification and Characterization of Mouse PSF1 Binding Protein, SLD5.2006

    • Author(s)
      Kong, L.
    • Journal Title

      Biochem.Biophys.Res.Commun. 339・4

      Pages: 1204-1207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.2005

    • Author(s)
      Fujito, T.
    • Journal Title

      J.Cell Biol. 171・1

      Pages: 165-173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Viral FLIP enhances Wnt signaling downstream of stabilized β-catenin, leading to control of cell growth.2005

    • Author(s)
      Nakagiri, S.
    • Journal Title

      Mol.Cell.Biol. 25・21

      Pages: 9249-9258

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Function of aPKClambda in differentiating photoreceptors is required for proper lamination of mouse retina.2005

    • Author(s)
      Koike, C.
    • Journal Title

      J.Neurosci. 25・44

      Pages: 10290-10298

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phospholipase C delta1 and delta3 are essential in the trophoblast for piacental development.2005

    • Author(s)
      Nakamura, Y.
    • Journal Title

      Mol.Cell Biol. 25・24

      Pages: 10979-10988

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.2005

    • Author(s)
      Nonaka, T.
    • Journal Title

      Mol.Cancer Ther. 4・8

      Pages: 1157-1166

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1(MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase(ARD) in the methionine salvage pathway2005

    • Author(s)
      Hirano, W.
    • Journal Title

      Genes Cells 10・6

      Pages: 565-574

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PSF1 is essential for early embryogenesis in mice.2005

    • Author(s)
      Ueno, M.
    • Journal Title

      Mol.Cell Biol. 25・23

      Pages: 10528-10532

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain.2005

    • Author(s)
      Koshikawa, N.
    • Journal Title

      J.Biol.Chem. 280・1

      Pages: 88-93

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cyclic AMP potentiates VE-cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.2005

    • Author(s)
      Fukuhara, S.
    • Journal Title

      Mol.Cell.Biol. 25・1

      Pages: 136-146

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhancement of serum and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK signaling.2004

    • Author(s)
      Kakunaga, S.
    • Journal Title

      J.Biol.Chem. 279・17

      Pages: 18015-18025

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.2004

    • Author(s)
      Fukuhara, T.
    • Journal Title

      J.Cell Biol. 166・3

      Pages: 393-405

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-{beta} Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor Cells.2004

    • Author(s)
      Sekiya, T.
    • Journal Title

      J.Biol.Chem. 279・8

      Pages: 6840-6846

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anteriorization of neural fate by ICAT, a negative regulator of Wnt signaling.2004

    • Author(s)
      Satoh, K.
    • Journal Title

      Proc.Nati.Acad.Sci.USA 101・21

      Pages: 8017-8021

    • Related Report
      2004 Annual Research Report
  • [Journal Article] aPKC acts upstream of PAR-1P in both the establishment and maintenance of mammalian epithelial polarity.2004

    • Author(s)
      Suzuki, A.
    • Journal Title

      Curr.Biol. 14・16

      Pages: 1425-1435

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.2004

    • Author(s)
      Yamaji, S.
    • Journal Title

      J.Cell Biol. 165・4

      Pages: 539-551

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.2004

    • Author(s)
      Kitajiri, S.
    • Journal Title

      J.Cell Biol. 116・4

      Pages: 559-570

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Establishment and characterization of cultured epithelial cells lacking expression of ZO-1.2004

    • Author(s)
      Umeda, K.
    • Journal Title

      J.Biol.Chem. 279・43

      Pages: 44785-44794

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase.2004

    • Author(s)
      Nakamura, H.
    • Journal Title

      Cancer Res. 64・3

      Pages: 876-882

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells

    • Author(s)
      Horikoshi, Y.
    • Journal Title

      Journal of Cell Science (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex.

    • Author(s)
      Nakamura, T.
    • Journal Title

      Genes Dev. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The overexpression and altered localization of the atypical Protein Kinase C lambda/iota in breast cancer correlates with the pathological type of these tumors.

    • Author(s)
      Kojima, Y
    • Journal Title

      Human Pathology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis.

    • Author(s)
      Kidoya, H.
    • Journal Title

      EMBO J. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PAR-3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.

    • Author(s)
      Hirose, T.
    • Journal Title

      Development in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hematopoietic cells regulate the angiogenic switch during tumorigenesis.

    • Author(s)
      Okamoto, R.
    • Journal Title

      Blood (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Presentation] Regulatory Mechanism of Active Zone Formation by Nectin-Afadin Adhesion System.2009

    • Author(s)
      Y.Takai
    • Organizer
      "Current Trends, in Biomedicine" workshop "Active Zones as organizers of neuronal communication"
    • Place of Presentation
      UNIA(Spain)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phospholipid-binding proteins that induce membrane deformation.2009

    • Author(s)
      Takenawa T.
    • Organizer
      Second International Conference on F-Bar proteins.
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Phospholipid-binding proteins that induce membrane deformation.2009

    • Author(s)
      T.Takenawa
    • Organizer
      Second International Conference on F-Bar proteins
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endogenous negative feedback regulation of angiogenesis by micro-RNA.2009

    • Author(s)
      高倉伸幸
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 細胞シグナリングと疾患モデルのプロテオミクス2009

    • Author(s)
      大野茂男
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      北里大学薬学部(東京都)
    • Year and Date
      2009-07-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞シグナリングと疾患モデルのプロテオミクス2009

    • Author(s)
      S.Ohno
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第7回大会
    • Place of Presentation
      北里大学薬学部(東京都)
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] PX-RICSはN-cadherin/β-catenin複合体の小胞体-ゴルジ体輸送を制御ずる2009

    • Author(s)
      中村勉
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epithelial Cell Polarity and the PAR-aPKC System2009

    • Author(s)
      Ohno, S.
    • Organizer
      The seventh annual CDB Symposium "Shape and Polarity" RIKEN
    • Place of Presentation
      Kobe
    • Year and Date
      2009-03-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞骨格・細胞接着シグナルの個体の組織形成での役割2008

    • Author(s)
      扇田久和
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌抑制遺伝子apcの機能2008

    • Author(s)
      秋山徹
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 癌抑制遺伝子APCの機能2008

    • Author(s)
      秋山徹
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 浸潤突起形成におけるリン脂質の役割2008

    • Author(s)
      伊藤俊樹、及川司、竹縄忠臣
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Roles and modes of action of nectins and afadin in synaptogenesis2008

    • Author(s)
      Yoshimi Takai
    • Organizer
      FENS 2008 Satellite Symposium "Cell-cell adhesion mechanisms : From development of synaptic networks to cognitive dysfunction"
    • Place of Presentation
      Switzerland (Geneva)
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん化による細胞接着・運動・増殖異常とその分子機構2008

    • Author(s)
      扇田久和
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] インシトールリン脂質結合ドメインによるシグナル分子の活性制御2007

    • Author(s)
      竹縄 忠臣
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会合同大会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞極性タンパク質、PAR-1βはユートロフィン・ジストログリカン複合体を制御することを介して細胞外ラミニンの集積を制御している2007

    • Author(s)
      鈴木 厚
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会合同大会ミンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Polarity protein PAR-1β regulates extracellular laminin organization through regulation of the utrophin-dystroglycan complex2007

    • Author(s)
      Suzuki, A.
    • Organizer
      Yokohama City University 21st Century COE Program, Cell Polarity 2007-International Symposium on Cell Polarity System and Future Medicine
    • Place of Presentation
      Hayama, Kanagawa
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Defective cell polarity in kidney podocytes causes severe glomerular disease2007

    • Author(s)
      Hirose, T.
    • Organizer
      Yokohama City University 21st Century COE Program, Cell Polarity 2007-International Symposium on Cell Polarity System and Future Medicine
    • Place of Presentation
      Hayama, Kanagawa
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of aPKCl in breast cance2007

    • Author(s)
      Akimoto, K.
    • Organizer
      Yokohama City University 21st Century COE Program, Cell Polarity 2007-International Symposium on Cell Polarity System and Future Medicine
    • Place of Presentation
      Hayama, Kanagawa
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular analysis of stemness and blood vessel formation regulated by Tie22007

    • Author(s)
      Takakura, N.
    • Organizer
      The first pacific symposium on angiogenesis and lymphangiogenesis
    • Place of Presentation
      Jeju Island, Korea
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌抑制遺伝子APCの機能2007

    • Author(s)
      秋山 徹
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] N-WASP/WAVEのシグナルとがん浸潤、転移2007

    • Author(s)
      竹縄 忠臣
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell-cell adhesion and formation of cell polarity2007

    • Author(s)
      高井 義美
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of nectin and nectin-like molecule in contact inhibition of cell movement2007

    • Author(s)
      Takai Y.
    • Organizer
      6th Abercrombie Meeting on Cell Migration: from molecules to organisms.
    • Place of Presentation
      Oxford, UK.
    • Year and Date
      2007-09-09
    • Related Report
      2009 Final Research Report
  • [Presentation] The SMG-1:SMG-8:p60 Complex Regulated Phosphorylation Of Upf1Is Required For The Dissociation Of eRFs From mRNA Surveillance Complex During Nonsense-mediated mRNA decay2007

    • Author(s)
      Yamashita, A.
    • Organizer
      第12回国際RNA学会年会
    • Place of Presentation
      University of Wisconsin, Madison
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cross-talk between cell-cell and cell-matrix junctions through nectin and nectin-like molecule2007

    • Author(s)
      高井 義美
    • Organizer
      Research ConferencesCell Contact & Adhesion
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of nectin and nectin-like molecule in contact inhibition of cell movement2007

    • Author(s)
      高井 義美
    • Organizer
      6th Abercrombie Meeting on Cell Migration: from molecules to organisms
    • Place of Presentation
      Oxford
    • Related Report
      2007 Annual Research Report
  • [Book] The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance.2009

    • Author(s)
      T ogashi H, Ogita H, Takai Y.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] The Sticky Synapse : Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance2009

    • Author(s)
      H.Togashi
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/mcb/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~ohnos/Japanease/indexJ.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/lipid/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cancercell/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://st.biken.osaka-u.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Remarks] 研究者が作成した研究内容に関するWebページ(大野研究室HP)

    • URL

      http://www-user.yokohama-cu.ac.jp/~ohnos//Japanease/indexJ.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] 所属研究機関が作成した研究成果のプレス発表のWebページ(横浜市立大学HP) 先端医科学研究センターの共同研究グループが、前立腺癌の再発を予測できる遺伝子を発見!(09/10/19)

    • URL

      http://www.yokohama-cu.ac.jp/amedrc/kubota091019.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] 所属研究機関が作成した研究成果のプレス発表のWebページ(横浜市立大学HP) 先端医科学研究センターの研究グループが、mRNAの品質監視のスイッチ機構を解明!(09/5/1)

    • URL

      http://www.yokohama-cu.ac.jp/amedrc/0501ohno.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] 所属研究機関が作成した研究成果のプレス発表のWebページ(横浜市立大学HP) 大野教授らの研究グループが腎糸球体の血液ろ過膜の機能維持に関わる新たな分子機構を発見!(09/1/14)

    • URL

      http://www.yokoham-cu.ac.jp/amedrc/090114ohno.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] (大野研究室HP)

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_takakura.php

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導遺伝子およびその利用2009

    • Inventor(s)
      秋山徹、廣子貴俊
    • Industrial Property Rights Holder
      大正製薬株式会社、秋山徹
    • Acquisition Date
      2009-12-25
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導遺伝子およびその利用2004

    • Inventor(s)
      秋山徹、廣子貴俊
    • Industrial Property Rights Holder
      大正製薬株式会社、秋山徹
    • Filing Date
      2004-02-10
    • Related Report
      2009 Final Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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