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Regulation of Bio-nanosystems

Research Project

Project/Area Number 16083101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo (2008-2009)
Tohoku University (2004-2007)

Principal Investigator

HIGUCHI Hideo  The University of Tokyo, 大学院・理学系研究科, 教授 (90165093)

Co-Investigator(Kenkyū-buntansha) SHINGYOJI Chikako  東京大学, 大学院・理学系研究科, 准教授 (80125997)
UCHIDA Takafumi  東北大学, 大学院・農学研究科, 教授 (80312239)
HIROSE Kenzo  東京大学, 大学院・医学系研究科, 教授 (00292730)
SUTOH Kazuo  東京大学, 大学院・総合文化研究科, 教授 (20111453)
Project Period (FY) 2004 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥68,300,000 (Direct Cost: ¥68,300,000)
Fiscal Year 2009: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2008: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2006: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2004: ¥4,400,000 (Direct Cost: ¥4,400,000)
Keywordsナノシステム / ダイニン / ミオシン / キネシン / 細胞 / 生体ナノシステム / タンパク質分子 / モーター / 制御
Research Abstract

1.平成21年7月に計画班代表及び分担者の成果発表会を東大にて開催した。特定領域研究において、須藤らが世界で初めて成功した活性の高い組換えダイニンの発現や、大岩や真行寺らが進めていた軸糸ダイニンの構造解析、樋口らが明らかにした活性の高い天然ダイニン1分子のステップサイズ・カ・速度、広瀬・真行寺らが明らかにした、ダイニンの微小管に結合したときの構造など、これらの研究成果や前回の全体発表会後に明らかになったことなどの発表があった。
2.特定領域全班員(計画班代表・分担と公募代表)から、成果の要点と業績リスト及び、主な論文を送ってもらい、整理し、概要をまとめ、報告書を作成した。
3.特定領域のホームページにて、成果を公表した。
4.特定領域全班員から集めた成果をまとめ、製本した報告書と論文集を作成し、全班員及び関係者へ郵送した。
5.終了後審査に向けて、審査委員にわかり易い図を作成した。
6.社会へのアウトプットとして、「Methods in Cell Blology」(Elsevier)から2分冊で,Axonemal Dynein-mediated Motility Intraclagellar Transportが出版された(編集:S.M.King and G.J.Pazour)。本領域からは6名が執筆者に加わった。2010年度中には「Handbook of Dynein」(Pan Stanford Publishing)の本の出版が予定されている(2009年末脱稿予定、編集者:L-A.Amos&広瀬恵子)。20名の世界の執筆者のうち,現在7名が本領域研究者の予定。
7.平成21年11月に「Dynein2009」が須藤を委員長(大岩、真行寺、豊島が実行委員)として開催された。これは世界最大のダイニン会議で、海外から約20名の招待研究者を招いて開催された。本領域研究者も多数参加し、領域の事後発表会としての役割も持つことになった。

Report

(7 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (87 results)

All 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article (41 results) (of which Peer Reviewed: 8 results) Presentation (25 results) Book (11 results) Remarks (4 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] In Vivo Nano-imaging of Membrane Dynamics in Metastatic Tumor Cells Using Quantum Dots2010

    • Author(s)
      K Gonda, T M. Watanabe N. Ohuchi, *H. Higuchi
    • Journal Title

      J. Biol. chem 285

      Pages: 2750-2757

    • Related Report
      2008 Final Research Report
  • [Journal Article] In Vivo Nano-imaging of Membrane Dynamics in Metastatic Tumor Cells Using Quantum Dots.2010

    • Author(s)
      K.Gonda., et.al
    • Journal Title

      J.Biol.chem. 285

      Pages: 2750-2757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic comparison of In vitro motile properties between chlamydomonas wild-type and mutant outer arm dyneins each lacking one of the three heavy chain2009

    • Author(s)
      Furuta A., T. Yagi, H. Yanagisawa, H. Higuchi, *R. Kamiya
    • Journal Title

      J. Biol. Chem 284

      Pages: 5927-5935

    • Related Report
      2008 Final Research Report
  • [Journal Article] Systematic comparison of In Vitro motile properties between chlamydomonas wild-type and mutant outer arm dyneins each lacking one of the three heavy chain.2009

    • Author(s)
      Furuta A., et. Al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 5927-5935

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular imaging of targeted proteins la-beled with Quantum Dots2008

    • Author(s)
      Yoo J., T. Kambara, K. Gonda, *H. Higuchi
    • Journal Title

      Exp Cell Res 314

      Pages: 3563-3569

    • Related Report
      2008 Final Research Report
  • [Journal Article] Single-Molecule Visualization of Diffusion at the Solution-Crystal Interface2008

    • Author(s)
      Sazaki, G., M. Okada, T. Matsui, T. Watanabe, H. Higuchi, K. Tsukamoto, K. Nakajima
    • Journal Title

      Crtstal Growth and Design 8

      Pages: 2024-2031

    • Related Report
      2008 Final Research Report
  • [Journal Article] Human Myosin Vc Is a Low Duty Ratio Nonprocessive Motor2008

    • Author(s)
      Watanabe S., T.M. Watanabe, O. Sato, J. Awata, K. Homma, N. Umeki, H. Higuchi, R. Ikebe, *M. Ikebe
    • Journal Title

      J. Biol. Chem 283

      Pages: 10581-10592

    • Related Report
      2008 Final Research Report
  • [Journal Article] Intracellular imaging of targeted proteins labeled with Quantum Dots.2008

    • Author(s)
      Yoo J., et.al.
    • Journal Title

      Exp Cell Res. 314

      Pages: 3563-3569

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Molecule Visualization of Diffusion at the Solution-Crystal Interface.2008

    • Author(s)
      Sazaki G., et.al.
    • Journal Title

      Crtstal Growth and Design. 8

      Pages: 2024-2031

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Myosin Vc is a Low Duty Ratio Nonprocessive Motor.2008

    • Author(s)
      Watanabe S., et.al.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 10581-10592

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human myosin Vc is a low duty ratio non-processive motor2008

    • Author(s)
      S. Watanabe et. al.
    • Journal Title

      J. of Biol. Chem. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional nanometry of vesicle transport in a living cell using dual-focus imaging optics2007

    • Author(s)
      Watanabe, T.M., T. Sato, K. Gonda, *H. Higuchi
    • Journal Title

      Biochem. Biophys. Res. Comm. In press

    • Related Report
      2008 Final Research Report
  • [Journal Article] Stepwise Movements in Vesicle Transport of HER2 by Motor Proteins in Living Cells2007

    • Author(s)
      Watanabe, T.M., *H. Higuchi
    • Journal Title

      Biophysical J. 92

      Pages: 1-12

    • Related Report
      2008 Final Research Report
  • [Journal Article] In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice2007

    • Author(s)
      H. Tada, *H. Higuchi, T.M. Wanatabe, N. Ohuchi
    • Journal Title

      Cancer Res. 67

      Pages: 1138-44

    • Related Report
      2008 Final Research Report
  • [Journal Article] Stepwise Movements in Vesicle Transport of HER2 by Motor Protein in Living Cells2007

    • Author(s)
      T. M. Watanabe and H. Higuchi
    • Journal Title

      Biophysical Journal 92

      Pages: 4109-4120

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional nanometry of vesicle transport in living cells using dual-focus imaging optics.2007

    • Author(s)
      T. M. Watanabe et. al.
    • Journal Title

      Biochem. Biophys. Res. Comm. 359

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice.2007

    • Author(s)
      H.Tada et al.
    • Journal Title

      Cancer Res. 67

      Pages: 1138-1144

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining2006

    • Author(s)
      S. Li-Shishido, T.M. Watanabe, H. Tada, *H. Higuchi, N. Ohuchi
    • Journal Title

      Biochem. Biophys. Res. Comm. 351

      Pages: 7-13

    • Related Report
      2008 Final Research Report
  • [Journal Article] Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein2006

    • Author(s)
      S. Toba, T.M. Watanabe, L-Y Okimoto, Y.Y. Toyoshima, *H. Higuchi
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 103

      Pages: 5741-45

    • Related Report
      2008 Final Research Report
  • [Journal Article] Single-Molecule Visuarization of Enviroment-Sensitive Fluorophores Inserted into cell membranes by Staphylococcal gamma-hemolysin2006

    • Author(s)
      A.H. Nguyen, V.T. Nguyen, Y. Kamio, H. Higuchi.
    • Journal Title

      Biochemistry 45

      Pages: 2570-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining.2006

    • Author(s)
      S.Li-Shishido et al.
    • Journal Title

      Biochem. Biophys. Res. Comm. 351

      Pages: 7-13

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 蛍光性量子ドットによるがん細胞の単一分子ナノイメージング2006

    • Author(s)
      樋口秀男 他
    • Journal Title

      バイオテクノロジージャーナル 12月号

      Pages: 30-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 生体分子モーターの1分子力学計測2006

    • Author(s)
      樋口秀男
    • Journal Title

      パリティ 22 (1)

      Pages: 47-48

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ナノメートル計測が拓く1分子の世界2006

    • Author(s)
      鳥羽栞 他
    • Journal Title

      バイオテクノロジージャーナル 9月号

      Pages: 600-604

    • Related Report
      2006 Annual Research Report
  • [Journal Article] チャールズ・デイ「DNAからRNAへの遺伝子情報転写のステップ運動をとらえた」訳2006

    • Author(s)
      チャールズ・デイ, 樋口秀男訳
    • Journal Title

      パリティ 21 (5)

      Pages: 32-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] バイオナノイメージングとナノ医療2006

    • Author(s)
      樋口秀男 他
    • Journal Title

      応用物理 75 (6)

      Pages: 694-698

    • NAID

      10019172511

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Single-Molecule Visuarization of Enviroment-Sensitive Fluorophores Inserted into cell membranes by Staphylococcal gamma-hemolysin.2006

    • Author(s)
      A.H.Nguyen
    • Journal Title

      Biochemistry (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Biased Binding of Single Molecules and Continuous Movement Of Multiple Molecules of Truncated Single-Headed Kinesin2005

    • Author(s)
      Takashi Kamei, Seiji Kakuta, *Hideo Higuchi
    • Journal Title

      Biophysical Journal 88

      Pages: 2068-77

    • Related Report
      2008 Final Research Report
  • [Journal Article] Motility of myosin V regulated by the dissociation of single calmodulin2005

    • Author(s)
      Nguyen HoaAnh, *Hideo Higuchi
    • Journal Title

      Nature Struct Mol Biol 12

      Pages: 127-132

    • Related Report
      2008 Final Research Report
  • [Journal Article] ナノバイオからナノ医学へ2005

    • Author(s)
      樋口秀男
    • Journal Title

      ナノ学会会報

      Pages: 35-41

    • NAID

      40006668513

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 分子イメージング、DDSによる診断・機能評価。(日本DDS学会編)「DDS研究の現状と将来展望」総説2005

    • Author(s)
      大内憲明
    • Journal Title

      Pharm Tech Japan 21(12)

      Pages: 59-62

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Motility of myosin V regulated by the dissociation of single calmodulin.2005

    • Author(s)
      Nguyen HoaAnh
    • Journal Title

      Nature Struct Mol Biol

    • Related Report
      2004 Annual Research Report
  • [Journal Article] W177 and R198, of LukF for Phosphatidylcholine-Binding and Pore-Formation by Staphylococcal {gamma}-Hemolysin on Human Erythrocyte Membranes2004

    • Author(s)
      Monma N, Nguyen VT, Kaneko J, Higuchi H, *Kamio Y. Essential Residues
    • Journal Title

      J Biochem (Tokyo). 136

      Pages: 427-431

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mechanochemical coupling of two substeps in a single myosin V motor2004

    • Author(s)
      Uemura S, Higuchi H, Olivares AO, De La Cruz EM, *Ishiwata S
    • Journal Title

      Nat Struct Mol Biol 11

      Pages: 877-83

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid double 8-nm steps by a kinesin mutant2004

    • Author(s)
      Higuchi H, Bronner CE, Park HW, *Endow SA
    • Journal Title

      EMBO J 23

      Pages: 2993-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Regional rheological differences in locomoting neutrophils2004

    • Author(s)
      Yanai, M.J.P. Butler, T. Suzuki. H. Sasaki, H. Higuchi
    • Journal Title

      Am. J. Physiol 287

      Pages: 603-611

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid double 8-nm steps by a kinesin mutant2004

    • Author(s)
      Higuchi H
    • Journal Title

      EMBO J

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanochemical coupling of two substeps in a single myosin V motor.2004

    • Author(s)
      Uemura S
    • Journal Title

      Nature Struct Mol Biol

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regional rheological differences in locomoting neutrophils.2004

    • Author(s)
      Yanai, M
    • Journal Title

      Am.J.Physiol.

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Biased Binding of Single Molecules and Continuous Movement Of Multiple Molecules of Truncated Single-Headed Kinesin.2004

    • Author(s)
      Takashi Kamei
    • Journal Title

      Biophysical Journal

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein.2003

    • Author(s)
      S.Toba et al.
    • Journal Title

      PNAS 103(15)

      Pages: 5741-5745

    • Related Report
      2006 Annual Research Report
  • [Presentation] Processive Movement by Mutant Cytoplasmic Dynein Heterodimers with an Inactive Head.2009

    • Author(s)
      Tomohiro Shima, et al.
    • Organizer
      American Society for Cell Biology's 49th Annual Meeting
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2009-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 共焦点観察によるマウス側脳室繊毛のnm精度運動2009

    • Author(s)
      下澤東吾, et.al.
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      徳島
    • Year and Date
      2009-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞質ダイニンのステップ機構2009

    • Author(s)
      島知弘, et.al.
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      徳島
    • Year and Date
      2009-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Non-Linear Elasticity of Single Skeletal Myosins is an Essential Mechanical Property of Muscle Contraction.2009

    • Author(s)
      茅元司, et.al.
    • Organizer
      The XXII Congress of the International Society of Biomechanics
    • Place of Presentation
      ケープタウン、南アフリカ
    • Year and Date
      2009-07-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] How Does The Dimeric Cytoplasmic Dynein Processively Walk on a Microtubule?2009

    • Author(s)
      Tomohiro Shima, et.al.
    • Organizer
      Biophysical Society's 53rd Annual Meeting
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2009-03-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Steps, Force and Motile Mechanism of Cytoplasmic Dynein2009

    • Author(s)
      Hideo Higuchi
    • Organizer
      Biophysical Society's 53rd Annual Meeting
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2009-03-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cargo Transport by Single Molecular Motors2009

    • Author(s)
      Higuchi, H.
    • Organizer
      The Biophysical Society's 53rd Annual Meeting
    • Place of Presentation
      Boston, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] Motility of single molecules of dynein, kinesin, and myosin in vitro and in cells2009

    • Author(s)
      Higuchi, H
    • Organizer
      Symposium on the MESO CONTROL of the cells, by the cells, for the cells.
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨格筋ミオシンのステッブサイズは負荷に伴い減少する2008

    • Author(s)
      茅元司, et.al.
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞質ダイニンー微小管結合の破断力2008

    • Author(s)
      岩崎聡, et.al.
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組換・天然・細胞内ダイニンの分子運動2008

    • Author(s)
      樋口秀男
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 量子ドットで標識したモータータンパク質の細胞内イメージング2008

    • Author(s)
      Jungwoo Yoo, et.al.
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanism of dynein motility in vitro and cells2008

    • Author(s)
      Higuchi, H.
    • Organizer
      The 46th Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Fukuoka, Japan.
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging of stepwise motility of single motor molecules in living cells2008

    • Author(s)
      Higuchi, H
    • Organizer
      39th NIPS International Symposium & 7th OIB Symposium
    • Place of Presentation
      Okazaki, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Myosin, kinesin and dynein in vitro and cells2008

    • Author(s)
      Higuchi, H.
    • Organizer
      nd International Symposium on Bio-nanosystems
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Step size and force generated by motor protein dynein2008

    • Author(s)
      Higuchi, H
    • Organizer
      236th National Meeting & Exposition of the American Chemical Society
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Step size of dynein is determined by distances of a power stroke and fluctuation2008

    • Author(s)
      Higuchi, H
    • Organizer
      Gordon Reserch Conferences
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Single molecule imaging of motor proteins in vitro and in vivo2008

    • Author(s)
      Higuchi, H
    • Organizer
      Bio-Soft Matter Workshop
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Step size and force generated by axonemal and cytoplasmic dynein2006

    • Author(s)
      Higuchi, H
    • Organizer
      Biophysical society Discussion meeting
    • Place of Presentation
      Alisoma, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Single molecule imaging of motor proteins in living cells2006

    • Author(s)
      Higuchi, H., T.M. Watanabe
    • Organizer
      The 7th international conference on systems Biology
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Introduction to the motor proteins2006

    • Author(s)
      Higuchi, H.
    • Organizer
      International symposium on Bio-nanosystems
    • Place of Presentation
      Mastushima, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Coordination of two single-headed cytoplasmic dyneins creates processive move-ment2006

    • Author(s)
      Higuchi, H.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Nano-biology and nano-medicine on can-cer cells2005

    • Author(s)
      Higuchi, H., T.M. Watanabe, H. Tada, N. Ohuchi
    • Organizer
      Nano-Science and Technology for Medical Applications.
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Nano-biology and nano-medicine on can-cer cells2005

    • Author(s)
      Higuchi, H., T.M. Watanabe, H. Tada, N. Ohuchi
    • Organizer
      Nano-Science and Technology for Medical Applications
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Biased Binding, Processive Steps and Oscillatory Movement of Single-headed Kinesin2004

    • Author(s)
      Higuchi, H
    • Organizer
      Structural Insights into Kinesin Function
    • Place of Presentation
      Washington, USA
    • Related Report
      2008 Final Research Report
  • [Book] METHODS IN CELL BIOLOGY : STRUCTURE AND MOTILITY, vol.912009

    • Author(s)
      Oiwa K., et.al.
    • Publisher
      Elsevier
    • Related Report
      2009 Annual Research Report
  • [Book] METHODS IN CELL BIOLOGY : MOTORS AND REGULATION, vol.922009

    • Author(s)
      Shingyoji C., et.al.
    • Publisher
      Elsevier
    • Related Report
      2009 Annual Research Report
  • [Book] 生命現象の動的理解を目指すライブイメージング(ナノメディシン)2008

    • Author(s)
      樋口秀男
    • Publisher
      羊土社
    • Related Report
      2008 Final Research Report
  • [Book] 単一量子ドットのバイオ・医療ナノイメージング(ナノメディシン)2008

    • Author(s)
      樋口秀男
    • Publisher
      Ohmsha
    • Related Report
      2008 Final Research Report
  • [Book] 実験医学増刊Vol.26 No.17生命現象の動的理解を目指すライブイメージング2008

    • Author(s)
      樋口秀男
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Book] 量子ドットを用いたがん細胞の単一分子イメージング(量子ドットの生命科学領域への応用)2007

    • Author(s)
      樋口秀男
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Book] 生体分子モーター(非侵襲・可視化技術ハンドブック)2007

    • Author(s)
      樋口秀男
    • Publisher
      NTS出版
    • Related Report
      2008 Final Research Report
  • [Book] 分子モーター概論(生物物理学ハンドブック)2007

    • Author(s)
      樋口秀男
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 生物物理学ハンドブック2007

    • Author(s)
      樋口秀男
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Book] 非侵襲・可視化技術ハンドブック2007

    • Author(s)
      樋口秀男
    • Publisher
      NTS出版
    • Related Report
      2007 Annual Research Report
  • [Book] 量子ドットの生命科学領域への応用2007

    • Author(s)
      樋口秀男
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Remarks] 特定領域研究「生体ナノシステムの制御」ホームページ

    • URL

      http://nanobio.phys.s.u-tokyo.ac.jp/NanoSystem/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://nanobio.phys.s.u-tokyo.ac.jp/NanoSystem/

    • Related Report
      2008 Final Research Report
  • [Remarks] 特定領域研究「生体ナノシステムの制御」ホームページ

    • URL

      http://nanobio.phys.s.u-tokyo.ac.jp/NanoSystem/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://web.tubero.tohoku.ac.jp/~nim/NanoSystem/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学装置及び結像方法2006

    • Inventor(s)
      渡邉朋信, 樋口秀男
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男
    • Acquisition Date
      2006-04-17
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学装置2005

    • Inventor(s)
      渡邉朋信, 樋口秀男, 佐藤崇
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男, 佐藤崇
    • Acquisition Date
      2005-11-22
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 位置解析方法及び位置解析装置2005

    • Inventor(s)
      渡邉朋信, 樋口秀男, 佐藤崇
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男
    • Acquisition Date
      2005-10-24
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] がん細胞への選択的作用組成物および治療用レーザー照射装置2005

    • Inventor(s)
      渡邉朋信, 樋口秀男, 佐藤崇
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男
    • Acquisition Date
      2005-06-03
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 顕微鏡ステージ、および、焦点位置計測装置と共焦点顕微鏡システム2005

    • Inventor(s)
      渡邉朋信, 樋口秀男, 佐藤崇
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男
    • Acquisition Date
      2005-04-27
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 単粒子三次元位置追跡方法2004

    • Inventor(s)
      渡邉朋信, 樋口秀男, 佐藤崇
    • Industrial Property Rights Holder
      渡邉朋信, 樋口秀男
    • Acquisition Date
      2004-10-18
    • Related Report
      2008 Final Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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