The molecular mechanisms of sex diffrentiation by nuclear hormone receptors

• Project/Area Number: 16086205
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEYAMA Ken-ichi The University of Tokyo, 分子細胞生物学研究所, 講師 (30323570)
• Co-Investigator(Kenkyū-buntansha): TAKADA Ichiro 東京大学, 分子細胞生物学研究所, 助教授 (50361655)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥47,500,000 (Direct Cost: ¥47,500,000); Fiscal Year 2008: ¥9,500,000 (Direct Cost: ¥9,500,000); Fiscal Year 2007: ¥9,500,000 (Direct Cost: ¥9,500,000); Fiscal Year 2006: ¥9,500,000 (Direct Cost: ¥9,500,000); Fiscal Year 2005: ¥9,500,000 (Direct Cost: ¥9,500,000); Fiscal Year 2004: ¥9,500,000 (Direct Cost: ¥9,500,000)
• Keywords: 性ステロイドホルモン / アンドロゲン / エストロゲン / 転写制御 / 核内受容体 / 核内レセプター / アンドロゲンレセプター / Notchシグナル / 脳の性分化 / エストロゲンレセプター / 転写共役因子 / 性分化 / 性行動

Research Abstract

本研究は性ホルモンの性分化作用機構を分子レベルで解明するため、性ホルモン受容体を介した転写制御機構に着目し解析を行った。第一に、組織特異的に性ホルモン受容体を欠く遺伝子変異マウスを作製し、表現型解析から性分化過程での生理学適宜を検討した。第二に、性ホルモン受容体の転写活性に必須となる転写共役因子群の機能解析により、組織特異的な転写制御機構を解明した。これらの機能解析により、これまで判然としなかった性ホルモンによる性分化機構が、性ホルモン受容体を介した転写制御により発揮されることが明確となった。

Research Products

• [Journal Article] DNA demethylation for hormone-induced transcriptional derepression (2009)
  • Author(s): Kim, M. S., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F. and Kato, S.
  • Journal Title: Nature (in press)
  • Peer Reviewed
• [Journal Article] GlcNAcylation of a histone methyltransferase in retinoic acid-induced granulopoiesis (2009)
  • Author(s): Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato, S.
  • Journal Title: Nature 459 Pages: 455-459
  • Peer Reviewed
• [Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity (2009)
  • Author(s): Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 3818-3822
  • Peer Reviewed
• [Journal Article] Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity (2009)
  • Author(s): Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y.. Yamagata, K., Tanabe, M., 1Cimura, S., Ueda, T., Fujiyama, S.. Lim, J., Matsukawa, H.. Kouemenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato. S.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 3818-3822
  • Peer Reviewed
• [Journal Article] Co-repressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system (2008)
  • Author(s): Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A.P., Li, F., Tabata, T. and Kato, S.
  • Journal Title: Mol Cell Biol 29 Pages: 1017-1034
  • Peer Reviewed
• [Journal Article] Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD (2008)
  • Author(s): Tanabe, M., Kouzmenko, AP., Ito, S., Sawatsubashi, S., Suzuki, E., Fujiyama, S., Yamagata, K., Zhao, Y., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Takeyama, K. and Kato, S.
  • Journal Title: Genes Cells 13 Pages: 1279-1288
  • Peer Reviewed
• [Journal Article] RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila (2008)
  • Author(s): Murata, T., Suzuki, E., Ito, S., Sawatsubashi, S., Zhao, Y., Yamagata, K., Tanabe, M., Fujiyama, S., Kimura, S., Ueda, T., Matsukawa, H., Kouzmenko, A., Furutani, T., Kuranaga, E., Miura, M., Takeyama, K. and Kato, S.
  • Journal Title: Biosci Biotechnol Biochem 72 Pages: 2255-2261
  • NAID: 10027531576
  • Peer Reviewed
• [Journal Article] Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor (2008)
  • Author(s): Kimura, S., Sawatsubashi, S., Ito, S., Kouzmenko, A., Suzuki, E., Zhao, Y., Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Yaegashi, N. and Kato, S.
  • Journal Title: Biochem Biophys Res Commun 371 Pages: 889-893
  • Peer Reviewed
• [Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha (2008)
  • Author(s): Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato, S.
  • Journal Title: EMBO Rep 9 Pages: 563-568
  • Peer Reviewed
• [Journal Article] A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor (2008)
  • Author(s): Iriyama, A., Fujiki, R., Inoue, Y., Takahashi, H., Tamaki, Y., Takezawa, S., Takeyama, K., Jang, W.D., Kato, S. and Yanagi Y.
  • Journal Title: J Biol Chem 283 Pages: 11947-11953
  • Peer Reviewed
• [Journal Article] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing (2008)
  • Author(s): Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H.G., Krasnov, A., Georgieva, S.G., Schule, R., Takeyama, K., Kato, S., Tora, L. and Devys, D.
  • Journal Title: Mol Cell 29 Pages: 92-101
  • Peer Reviewed
• [Journal Article] Dihydrotestosterone inhibits murine hair growth via the androgen receptor (2008)
  • Author(s): Naito, A., Sato, T., Matsumoto, T., Takeyama, K., Yoshino, T., Kato, S. and Ohdera, M.
  • Journal Title: Br J Dermatol 159 Pages: 300-305
  • Peer Reviewed
• [Journal Article] Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli (2008)
  • Author(s): Kouzmenko, A. P., Takeyama, K., Kawasaki, Y., Akiyama, T. and Kato, S.
  • Journal Title: Genes Cells 13 Pages: 723-730
  • Peer Reviewed
• [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli (2008)
  • Author(s): Kouzmenko, A.P., Takeyama, K., Kawasaki, Y., Akiyama, T. and Kato, S.
  • Journal Title: Oncogene 27 Pages: 4888-4899
  • Peer Reviewed
• [Journal Article] Co-repressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system (2008)
  • Author(s): Zhao. Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y, Kouzunenko, A.P., Li, F., Tabata, T. and Kato. S.
  • Journal Title: Mol Cell Biol 29 Pages: 1017-1034
  • Peer Reviewed
• [Journal Article] A TFTC/STAGA Module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing (2008)
  • Author(s): Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H. G., Krasnov, A., Georgieva, S. G., Schule, R., Takeyama, K., Kato, S., Tora, L. and Devys, D.
  • Journal Title: Mol. Cell 29 Pages: 92-101
  • Peer Reviewed
• [Journal Article] Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts (2007)
  • Author(s): Takada, I., Suzawa, M., Matsumoto, K. and Kato, S.
  • Journal Title: Ann N Y Acad Sci 1116 Pages: 182-195
  • Peer Reviewed
• [Journal Article] Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene (2007)
  • Author(s): Igarashi, M., Yogiashi, Y., Mihara, M., Takada, I., Kitagawa, H. and Kato, S.
  • Journal Title: Mol Cell Biol 27 Pages: 7947-7954
  • Peer Reviewed
• [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation (2007)
  • Author(s): Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M. Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K. and Kato, S.
  • Journal Title: Nat Cell Biol 9 Pages: 1273-1285
  • Peer Reviewed
• [Journal Article] High-throughput system for analyzing ligand-induced cofactor recruitment by vitamin D receptor (2007)
  • Author(s): Arai, M. A., Takeyama, K., Ito, S., Kato, S., Chen, T. C. and Kittaka, A.
  • Journal Title: Bioconjug Chem 18 Pages: 614-620
  • Peer Reviewed
• [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase (2007)
  • Author(s): Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A. P., Nohara, K., Chiba, T., Fujii-Kuriyama, Y. and Kato, S.
  • Journal Title: Nature 446 Pages: 562-566
  • Peer Reviewed
• [Journal Article] Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure (2007)
  • Author(s): Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K. and Kato, S.
  • Journal Title: Trends Endocrinol Metab 18 Pages: 183-189
  • Peer Reviewed
• [Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs (2007)
  • Author(s): Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B. W. and Kato, S.
  • Journal Title: Nat Cell Biol 9 Pages: 604-611
  • Peer Reviewed
• [Journal Article] Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes (2007)
  • Author(s): Memezawa, A., Takada, I., Takeyama, K., Igarashi, M., Ito, S., Aiba, S., Kato, S. and Kouzmenko, A. P.
  • Journal Title: Oncogene 26 Pages: 5038-5045
  • Peer Reviewed
• [Journal Article] A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function (2007)
  • Author(s): Takezawa, S., Yokoyama, A., Okada, M., Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H. and Kato, S.
  • Journal Title: EMBO J 26 Pages: 764-774
  • Peer Reviewed
• [Journal Article] 1Alpha, 25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter (2007)
  • Author(s): Kim, M. S., Fujiki, R., Murayama, A., Kitagawa, H., Yamaoka, K., Yamamoto, Y., Mihara, M., Takeyama, K. and Kato, S.
  • Journal Title: Mol Endocrinol 21 Pages: 334-342
  • Peer Reviewed
• [Journal Article] The pituitary function of androgen receptor constitutes a glucocorticoid production circuit (2007)
  • Author(s): Miyamoto, J., Matsumoto, T., Shiina, H., Inoue, K., Takada, I., Ito, S., Itoh, J., Minematsu, T., Sato, T., Yanase, T., Nawata, H., Osamura, Y. R. and Kato, S.
  • Journal Title: Mol Cell Biol 24 Pages: 4807-4814
  • Peer Reviewed
• [Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of MicroRNAs (2007)
  • Author(s): Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B. W. and Kato, S.
  • Journal Title: Nat. Cell Biol. 9 Pages: 604-611
  • Peer Reviewed
• [Journal Article] Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure (2007)
  • Author(s): Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K. and Kato, S.
  • Journal Title: Trends Endocrinol. Metab. 18 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure. (2007)
  • Author(s): Kimura S. et al.
  • Journal Title: Trends Endocrinol Metab. (In press)
• [Journal Article] DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. (2007)
  • Author(s): Fukuda T. et al.
  • Journal Title: Nat Cell Biol. (In press)
• [Journal Article] Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes. (2007)
  • Author(s): Memezawa A. et al.
  • Journal Title: Oncogene. (In press)
• [Journal Article] A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function. (2007)
  • Author(s): Takezawa S. et al.
  • Journal Title: EMBO J. 26 Pages: 764-774
• [Journal Article] 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter. (2007)
  • Author(s): Kim M.et al.
  • Journal Title: Mol Endocrinol. 21 Pages: 334-342
• [Journal Article] High-Throughput System for Analyzing Ligand-Induced Cofactor Recruitment by Vitamin D Receptor. (2007)
  • Author(s): Arai M.et al.
  • Journal Title: Bioconjug Chem. (In press)
• [Journal Article] Culture serum-induced conversion from agonist to antagonist of a Vitamin D analog, TEI-9647 (2006)
  • Author(s): Yamaoka, K., Kim, M., Takada, I., Takeyama, K., Kamimura, T. and Kato, S.
  • Journal Title: J Steroid Biochem Mol Biol 100 Pages: 177-183
  • Peer Reviewed
• [Journal Article] Premature ovarian failure in androgen receptor-deficient mice (2006)
  • Author(s): Shiina, H., Matsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., Metzger, D., Chambon, P., Kanno, J., Yoshikawa, H. and Kato, S.
  • Journal Title: Proc Natl Acad Sci USA 103 Pages: 224-229
  • Peer Reviewed
• [Journal Article] An hGCN5/TRRAP HAT complex coactivates BRCA1 transactivation function through histone modification (2006)
  • Author(s): Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Tora, L., Kouzu-Fujita, M., Takada, I., Yano, T., Yanagisawa, J. and Kato, S.
  • Journal Title: J Biol Chem 281 Pages: 20-26
  • Peer Reviewed
• [Journal Article] Human expanded polyQ androgen receptor mutants in neurodegeneration as a novel ligand target (2005)
  • Author(s): Furutani, T., Takeyama, K., Koutoku, H., Ito S., Taniguchi N., Suzuki E., Kudoh, M., Shibasaki, M., Shikama, H. and Kato, S.
  • Journal Title: J Pharmacol Exp Ther 315 Pages: 545-552
  • Peer Reviewed
• [Journal Article] A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line (2005)
  • Author(s): Furutani, T., Takeyama, K., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., Kudoh, M., Shibasaki, M., Shikama, H. and Kato, S.
  • Journal Title: Biosci Biotechnol Biochem 69 Pages: 2236-2239
  • NAID: 130000030502
  • Peer Reviewed
• [Journal Article] Study of androgen receptor functions by genetic models (2005)
  • Author(s): Matsumoto, T., Takeyama, K., Sato, T. and Kato, S.
  • Journal Title: J Biochem 138 Pages: 105-110
  • NAID: 10017346349
  • Peer Reviewed
• [Journal Article] Splicing potentiation by growth factor signals via estrogen receptor phosphorylation (2005)
  • Author(s): Masuhiro, Y., Mezaki, Y., Sakari, M., Takeyama, K., Yoshida, T., Inoue, K., Yanagisawa, J., Hanazawa, S., O'Malley, B. W. and Kato, S.
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 8126-8131
  • Peer Reviewed
• [Journal Article] Nuclear receptors as targets for drug development : Crosstalk between peroxisome proliferator-activated receptor γ and cytokines in bone marrow-derived mesenchymal stem cells (2005)
  • Author(s): Takada, I., Suzawa M. and Kato, S.
  • Journal Title: J Pharamcol Sci 97 Pages: 184-189
  • NAID: 10025725865
  • Peer Reviewed
• [Journal Article] TRRAP as a hepatic coactivator of LXR and FXR function (2005)
  • Author(s): Unno, A., Takada, I., Takezawa, S., Oishi, H., Baba, A., Shimizu, T., Tokita, A., Yanagisawa, J. and Kato, S.
  • Journal Title: Biochem Biophys Res Commun 327 Pages: 933-938
  • Peer Reviewed
• [Journal Article] Human expanded polyglutamine androgen receptor mutants in neurogeneration as a novel ligand target (2005)
  • Author(s): Furutani, T., Takeyama, K., Tanabe, M., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., Kudoh, M., Shibasaki, M., Shikama, H., Kato, S.
  • Journal Title: J Pharmacol Exp Ther 315 Pages: 545-552
• [Journal Article] A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line (2005)
  • Author(s): Furutani, T., Takeyama, K., Koutoku, H., Ito, S., Taniguchi, N., Suzuki, E., Kudoh, M., Shibasaki, M., Shikama, H., Kato, S.
  • Journal Title: Biosci Biotechnol Biochem 69 Pages: 2236-2239
  • NAID: 130000030502
• [Journal Article] Splicing potentiation by growth factor signals via estrogen receptor phosphorylation (2005)
  • Author(s): Masuhiro, Y., Mezaki, Y., Sakari, M., Takeyama, K., Yoshida, T., Inoue, K., Yanagisawa, J., Hanzawa, S., O'Malley B, W., Kato, S.
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 8126-8131
• [Journal Article] Study of androgen receptor functions by genetic models (2005)
  • Author(s): Matsumoto, T., Takeyama, K., Sato, T., Kato, S.
  • Journal Title: J Biochem(Tokyo) 138 Pages: 105-110
  • NAID: 10017346349
• [Journal Article] Wnt/beta -catenin and estrogen signaling converge in vivo (2004)
  • Author(s): Kouzmenko, A. P., Takeyama, K., Ito, S., Furutani, T., Sawatsubashi, S., Maki, A., Suzuki, E., Kawasaki, Y., Akiyama, T., Tabata, T. and Kato, S.
  • Journal Title: J Biol Chem 279 Pages: 40255-40258
  • Peer Reviewed
• [Journal Article] Function of androgen receptor in gene regulations (2004)
  • Author(s): Kato, S., Matsumoto, T., Kawano, H., Sato, T. and Takeyama, K.
  • Journal Title: J Steroid Biochem Mol Biol 89-90 Pages: 627-633
  • Peer Reviewed
• [Journal Article] In vivo potentiation of human oestrogen receptor αby Cdk7-mediated phosphorylation (2004)
  • Author(s): Ito, S., Takeyama, K., Yamamoto, A., Sawatsubashi, S., Shirode, Y., Kouzmenko, A. P., Tabata, T. and Kato, S.
  • Journal Title: Genes Cells 9 Pages: 983-992
  • Peer Reviewed
• [Journal Article] BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220 (2004)
  • Author(s): Wada, O., Oishi, H., Takada, I., Yanagisawa, J., Yano, T. and Kato, S.
  • Journal Title: Oncogene 23 Pages: 6000-6005
  • Peer Reviewed
• [Journal Article] A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor (2004)
  • Author(s): Takeyama, K., Ito, S., Sawatsubashi, S., Shirode, Y., Yamamoto, A., Suzuki, E., Maki, A., Yamagata, K., Zhao, Y., Kouzmenko, A. P., Tabata, T.and Kato, S.
  • Journal Title: Biosci Biotechnol Biochem 68 Pages: 1209-1215
  • NAID: 10013286337
  • Peer Reviewed
• [Journal Article] Ecdysone receptor-dependent gene regulation mediates histone poly (ADP-ribosyl)ation (2004)
  • Author(s): Sawatsubashi, S., Maki, A., Ito, S., Shirode, Y., Suzuki, E., Zhao, Y., Yamagata, K., Kouzmenko, A., Takeyama, K. and Kato, S.
  • Journal Title: Biochem Biophys Res Commun 320 Pages: 268-272
  • Peer Reviewed
• [Journal Article] Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching (2004)
  • Author(s): Murayama, A., Kim, M. S., Yanagisawa, J., Takeyama, K. and Kato, S.
  • Journal Title: EMBO J 23 Pages: 1598-1608
  • Peer Reviewed
• [Journal Article] Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers (2004)
  • Author(s): Maki, A., Sawatsubashi, S., Ito, S., Shirode, Y., Suzuki, E., Zhao, Y., Yamagata, K., Kouzmenko, A., Takeyama, K. and Kato, S.
  • Journal Title: Biochem Biophys Res Commun 320 Pages: 262-267
• [Journal Article] A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor (2004)
  • Author(s): Takeyama K., Ito S., Sawatsubashi S., et al.
  • Journal Title: Biosci Biotechnol Biochem. 68・6 Pages: 1209-1215
  • NAID: 10013286337
• [Journal Article] Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching (2004)
  • Author(s): Murayama A., Kim M., Yanagisawa J., Takeyama K., Kato S.
  • Journal Title: EMBO J. Apr 07・23 Pages: 1598-1608
• [Journal Article] Wnt/beta-catenin and estrogen signaling converge in vivo. (2004)
  • Author(s): Kouzmenko AP., Takeyama K., Ito S., et al.
  • Journal Title: J Biol Chem. 279・39 Pages: 40255-40258
• [Journal Article] In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation. (2004)
  • Author(s): Ito S., Takeyama K., Yamamoto A., et al.
  • Journal Title: Genes Cells. Oct;9・10 Pages: 983-992
• [Journal Article] Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. (2003)
  • Author(s): Ohtake F., Takeyama K., Matsumoto T., et al.
  • Journal Title: Nature 423・6939 Pages: 545-550
• [Journal Article] Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila (2002)
  • Author(s): Takeyama K., Ito S., Yamamoto A., et al.
  • Journal Title: Neuron 35・5 Pages: 855-864
• [Presentation] 新規クロマチン構造調節因子BAHD1を介した転写抑制機構の解明 (2008)
  • Author(s): 伊藤紗弥, 沢津橋俊, 鈴木絵里子, 趙越, 山形薫, 田辺真彦, 木村周平, 上田崇, 藤山沙理, 村田拓哉, 松川紘之, 林珍仙, 武山健一, 加藤茂明
  • Organizer: 第31回日本分子生物学会、第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 骨芽細胞におけるエストロゲンの作用の解明-骨芽細胞特異的エストロゲン受容体欠損マウスを用いて (2008)
  • Author(s): 金藤紫乃, 今井祐記, 高田伊知郎, 中村貴, 松本高広, 加藤茂明
  • Organizer: 第31回日本分子生物学会、第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] エストロゲンによるmiRNA産生抑制機構の解析 (2008)
  • Author(s): 山形薫, 鈴木絵里子, 沢津橋俊, 伊藤紗弥, 藤山沙理, 田辺真彦, 上田崇, 村田拓哉, 趙越, 松川紘之, 林珍仙, 汐崎裕美, 武山健一, 加藤茂明
  • Organizer: 第31回日本分子生物学会、第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] ショウジョウバエZn-fingerタンパクZ4の新規クロマチン凝集化機能の解析 (2008)
  • Author(s): 村田拓哉, 沢津橋俊, 伊藤紗弥, 鈴木絵里子, 山形薫, 趙越, 田辺真彦, 藤山沙理, 木村周平, 上田崇, 松川紘之, 林珍仙, 武山健一, 加藤茂明
  • Organizer: 第31回日本分子生物学会、第81回日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 成熟多核破骨細胞におけるエストロゲン受容体ERαの発現解析 (2008)
  • Author(s): 延〓榮, 高田伊知郎, 金藤紫乃, 今井祐記, 加藤茂明
  • Organizer: 第26回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] 分子遺伝学的手法による新規転写共役因子の網羅的探索法の構築と機能解析 (2008)
  • Author(s): 武山健一, 伊藤紗弥, 沢津橋俊, 鈴木絵里子, 趙越, 山形薫, 田辺真彦, 木村周平, 上田崇, 藤山沙理, 村田拓也, 松川紘之, Alexander Kouzmenko, 加藤茂明
  • Organizer: 2008年度日本農芸化学会大会
  • Place of Presentation: 名古屋
• [Presentation] ビタミンD一位水酸化酵素遺伝子の活性型ビタミンD依存的な転写抑制解除にはDNA脱メチル化機構が関与する (2007)
  • Author(s): 金美善, 高田伊知郎, 武山健一, 加藤茂明
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] 細胞周期依存的なERαの機能解析 (2007)
  • Author(s): 岡田麻衣子, 竹澤慎一郎, 目崎喜弘, 高田伊知郎, 北川浩史, 加藤茂明
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] グルカゴン/PKAシグナル依存的なFXR新規転写共役因子複合体の解析 (2007)
  • Author(s): 馬場敦史, 大竹史明, 高田伊知郎, 加藤茂明
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] 遺伝学的アプローチとプロテオミクスを連携した新規活性化クロマチン構造調節因子の網羅的探索と機能解析 (2007)
  • Author(s): 藤山沙理, 沢津橋俊, 鈴木絵里子, 伊藤紗弥, 田辺真彦, 趙越, 木村周平, 上田崇, 山形薫, 村田拓哉, 松川紘之, 武山健一, 加藤茂明
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 横浜
• [Presentation] Notchシグナル伝達依存的な新規転写抑制因子の同定と機能解析 (2007)
  • Author(s): 武山健一, 伊藤紗弥, 沢津橋俊, Alexander Kouzmenko, 鈴木絵里子, 山形薫, 趙越, 田辺真彦, 木村周平, 上田崇, 村田拓也, 藤山沙理, 加藤茂明
  • Organizer: 2007年度日本農芸化学会大会
  • Place of Presentation: 東京
• [Presentation] Wntシグナル依存的なPPARgamma活性制御機構の解析 (2007)
  • Author(s): 高田伊知郎, 三原政朋, 加藤茂明
  • Organizer: 2007年度日本農芸化学会大会
  • Place of Presentation: 東京
• [Presentation] DEAD Box RNA helicase p72/p68によるmiRNA processingの機能解析 (2006)
  • Author(s): 山形薫, 福田亨, 藤山沙理, 越田伊織, 武山健一, 松本高広, 北川浩史, 加藤茂明
  • Organizer: 2006年度日本農芸化学会大会
  • Place of Presentation: 京都
• [Presentation] 肝臓特異的FXR転写共役因子複合体精製の新たな試み (2006)
  • Author(s): 馬場敦史, 大竹史明, 三木ひろみ, 北川浩史, 高田伊知郎, 加藤茂明
  • Organizer: 2006年度日本農芸化学会大会
  • Place of Presentation: 京都
• [Presentation] 分子遺伝学的アプローチによるヒト核内レセプター新規転写共役因子BAHD1の機能解析 (2006)
  • Author(s): 伊藤紗弥, 武山健一, 沢津橋俊, 鈴木絵里子, Yue Zhao, 山形薫, 田辺真彦, Alexander Kouzmenko, 城出裕子, 多羽田哲也, 加藤茂明
  • Organizer: 2006年度日本農芸化学会大会
  • Place of Presentation: 京都
• [Presentation] クロマチン構造を介したエクダイソンレセプター転写制御機構の解明に関する研究 (2006)
  • Author(s): 沢津橋俊, 武山健一, 伊藤紗弥, 鈴木絵里子, 田辺真彦, 趙越, 山形薫, 城出裕子, 多羽田哲也, 加藤茂明
  • Organizer: 2006年度日本農芸化学会大会
  • Place of Presentation: 京都
• [Presentation] ヒストン修飾を介したWntシグナルと核内レセプター PPARγのクロストーク分子機構の解析 (2006)
  • Author(s): 高田伊知郎, 須澤美幸, 松本邦弘, 加藤茂明
  • Organizer: 2006年度日本農芸化学会大会
  • Place of Presentation: 京都
• [Presentation] クロマチン構造を介したエクダイソンレセプター転写制御機構の解明に関する研究 (2005)
  • Author(s): 沢津橋俊, 武山健一, 伊藤紗弥, 鈴木絵里子, 田辺真彦, 趙越, 山形薫, 城出裕子, 多羽田哲也, 加藤茂明
  • Organizer: 第28回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] 選択的エストロゲン受容体モジュレーター(SERM)結合エストロゲン受容体転写制御機構の解析 (2005)
  • Author(s): 目崎喜弘, 神津円, 高田伊知郎, 北川浩史, 加藤茂明
  • Organizer: 第28回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] ポリグルタミン鎖伸長異常アンドロゲンレセプターによって引き起こされる神経変性はRb/E2F-1転写調節機能の抑制化により回復する (2005)
  • Author(s): 鈴木絵里子, 武山健一, 伊藤沙弥, 沢津橋俊, 城出裕子, 真木彰郎, 山形薫, 趙越, Alexandr Kouzmenko, 相垣敏郎, 多羽田哲也, 加藤茂明
  • Organizer: 2005年度日本農芸化学会大会
  • Place of Presentation: 札幌
• [Presentation] 分子遺伝学的アプローチによるヒト核内レセプター転写共役因子の探索と機能解析 (2005)
  • Author(s): 武山健一, 伊藤紗弥, 沢津橋俊, 城出裕子, 鈴木絵里子, 真木彰郎, 趙越, 山形薫, Alexander Kouzmenko, 田辺真彦, 多羽田哲也, 加藤茂明
  • Organizer: 2005年度日本農芸化学会大会
  • Place of Presentation: 札幌
• [Presentation] non-canonical Wnt pathwayによる核内レセプターPPARγ転写抑制機構の解析 (2005)
  • Author(s): 高田伊知郎, 須沢美幸, 松本邦弘, 加藤茂明
  • Organizer: 2005年度日本農芸化学会大会
  • Place of Presentation: 札幌
• [Presentation] アンドロゲンレセプターを介したE2F-1/Rb転写制御機構の解析 (2004)
  • Author(s): 鈴木絵里子, 武山健一, 伊藤紗弥, 沢津橋俊, 城出裕子, 真木彰郎, 山形薫, 趙越, Alexander Kouzmenko, 相垣敏郎, 多羽田哲也, 加藤茂明
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] 分子遺伝学的アプローチによるヒト性ステロイドホルモンレセプター新規転写制御因子の網羅的Screening系の構築 (2004)
  • Author(s): 伊藤紗弥, 武山健一, 沢津橋俊, Alexandre Kouzmenko, 城出裕子, 鈴木絵里子, 真木彰郎, Yue Zhao, 山形薫, 相垣敏郎, 多羽田哲也, 加藤茂明
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] non-canonical Wnt pathwayによる核内レセプターPPARγ転写抑制機構の解析 (2004)
  • Author(s): 高田伊知郎, 須沢美幸, 松本邦弘, 加藤茂明
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸