information processing mechanisms in an inter-neuronal circuit

• Project/Area Number: 16H02516
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Nagoya University
• Principal Investigator: Mori Ikue 名古屋大学, 理学研究科, 教授 (90219999)
• Research Collaborator: NAKANO Shunji ; TSUKADA Yuki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000); Fiscal Year 2018: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
• Keywords: 神経回路 / 意思決定 / 行動選択 / 情報処理 / C.elegans

Outline of Final Research Achievements

We focused on an inter-neuronal circuit that regulates behavioral mode of animals. Comprehensive analysis including time courses of behavior and neural activity showed elements of behavior to explore and navigate animals on thermal environments. Mathematical analysis clarifies quantitative data so that we could identify functional neural circuits for the behavioral regulation. We also established quantitative perturbation methods for neural activity analysis and successfully determined some states of the target neural circuit.

Academic Significance and Societal Importance of the Research Achievements

探索行動のような、単一の動作にとどまらず一連の行動系列として機能を持つ行動を実現する神経回路メカニズムの理解は、重要であるにも関わらずあまり理解が進んでいなかった。また介在神経細胞の行動に対する関与も感覚神経細胞や運動神経細胞に比べて不明であった。本研究で介在神経細胞に注目し、機能的な神経回路としてどのように行動モードを制御しているかを明らかにすることで、柔軟な環境への対応を実現する神経回路メカニズムの一端が明らかとなった。

Research Products

• [Journal Article] KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain (2019)
  • Author(s): An Seon Woo A.、Choi Eun-Seok、Hwang Wooseon、Son Heehwa G.、Yang Jae-Seong、Seo Keunhee、Nam Hyun-Jun、Nguyen Nhung T. H.、Kim Eun Ji E.、Suh Bo Kyoung、Kim Youngran、Nakano Shunji、Ryu Youngjae、Man Ha Chang、Mori Ikue、Park Sang Ki、Yoo Joo-Yeon、Kim Sanguk、Lee Seung-Jae V.
  • Journal Title: Aging Cell Volume: e12906 Issue: 3
  • DOI: 10.1111/acel.12906
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SLO potassium channels antagonize premature decision making in C. elegans (2018)
  • Author(s): Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
  • Journal Title: Commun Biol. Volume: 1 Issue: 1 Pages: 123-123
  • DOI: 10.1038/s42003-018-0124-5
  • Peer Reviewed / Open Access
• [Journal Article] Identification of animal behavioral strategies by inverse reinforcement learning. (2018)
  • Author(s): Yamaguchi S, Honda N*, Ikeda M, Tsukada Y, Nakano S, Mori I and Ishii S
  • Journal Title: PLoS Computational Biology Volume: 14(5) Issue: 5 Pages: e1006122-e1006122
  • DOI: 10.1371/journal.pcbi.1006122
  • NAID: 120006469168
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 「細胞運動の定量生物学"定量生物学」 (2018)
  • Author(s): 高木 拓明, 塚田 祐基
  • Journal Title: 化学同人 Volume: - Pages: 35-54
• [Journal Article] 「"個体行動の定量生物学" 定量生物学」 (2018)
  • Author(s): 塚田 祐基
  • Journal Title: 化学同人 Volume: - Pages: 146-161
• [Journal Article] SLO potassium channels antagonize premature decision making in C. elegans (2018)
  • Author(s): Aoki M, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
  • Journal Title: Cold Spring Harbor Laboratory bioRxiv Volume: -
  • DOI: 10.1101/243220
  • Open Access
• [Journal Article] Thermosensory Neuronal Encoding of Spatial Temperature Gradient in <i>C. elegans</i> Thermotaxis (2018)
  • Author(s): 塚田祐基, 森郁恵
  • Journal Title: Seibutsu Butsuri Volume: 58 Issue: 1 Pages: 031-033
  • DOI: 10.2142/biophys.58.031
  • NAID: 130006322050
  • ISSN: 0582-4052, 1347-4219
  • Peer Reviewed / Open Access
• [Journal Article] Molecular Mechanisms of learning in C. elegans" In: Learning and Memory: A Comprehensive Reference 2nd Edition (Ed：Byrne) (2017)
  • Author(s): Aoki, I., Nakano, S., Mori, I.
  • Journal Title: Elsevier Volume: - Pages: 415-434
• [Journal Article] Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans. (2017)
  • Author(s): Sasakura H, Moribe H, Nakano M, Ikemoto K, Takeuchi K,
  • Journal Title: J Cell Sci. Volume: 130 Issue: 15 Pages: 2631-2643
  • DOI: 10.1242/jcs.202119
  • Peer Reviewed / Open Access
• [Journal Article] Identification of animal behavioral strategies by inverse reinforcement learning (2017)
  • Author(s): Yamaguchi S, Honda N, Ikeda M, Tsukada Y, Nakano S, Mori I and Ishii S
  • Journal Title: bioRxiv Volume: 129007 Pages: 129007-129007
  • DOI: 10.1101/129007
  • NAID: 120006469168
  • Open Access / Int'l Joint Research
• [Journal Article] Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes (2017)
  • Author(s): Taniguchi Atsushi、Kimura Yukiko、Mori Ikue、Nonaka Shigenori、Higashijima Shin-ichi
  • Journal Title: Development, Growth & Differentiation Volume: 59 Issue: 9 Pages: 741-748
  • DOI: 10.1111/dgd.12412
  • Peer Reviewed / Open Access
• [Presentation] Alteration of Synaptic Valence Controls a C. elegans Navigation Behavior (2019)
  • Author(s): Shunji Nakano, Muneki Ikeda, Yuki Tsukada, Xianfeng Fei, Takamasa Suzuki, Rhea Ahluwalia, Ayana Sano, Rumi Kondo, Kunio Ihara, Koichi Hashimoto, Tetsuya Higashiyama, Ikue Mori,
  • Organizer: UK-Japan Neuroscience Symposium
  • Int'l Joint Research
• [Presentation] フェムトセカンドレーザーと光遺伝学を使った単一シナプスレベルの神経回路機能解析 (2019)
  • Author(s): 塚田 祐基
  • Organizer: 定量生物学の会
• [Presentation] Exploitation and exploration modes in a C. elegans navigation behavior (2018)
  • Author(s): Mori I
  • Organizer: 3 Days Exploration of Reinforcement Learning & Biological Intelligence
  • Int'l Joint Research
• [Presentation] Regulation of timing for decision making in C. elegans. (2018)
  • Author(s): Ichiro Aoki, Ikue Mori
  • Organizer: 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Alteration between positive and negative valence of a neuronal connection shapes a C. elegans navigation behavior (2018)
  • Author(s): Shunji Nakano, Muneki Ikeda, Yuki Tsukada, Ayana Sano, Rumi Kondo, Takamasa Suzuki, Tetsuya Higashiyama, Ikue Mori,
  • Organizer: 41st Annual Meeting of the Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Identification of Animal Behavioral Strategies by Inverse Reinforcement Learning. (2018)
  • Author(s): Honda Naoki, Shoichiro Yamaguchi, Muneki Ikeda, Yuki Tsukada, Shunji Nakano, Ikue Mori, Shin Ishii
  • Organizer: 41st Annual Meeting of the Japan Neuroscience Society of Animal Behavioral Strategies by Inverse Reinforcement Learning.
  • Int'l Joint Research
• [Presentation] 線虫の行動と脳神経回路の包括的解析から、記憶、学習、意思決定のメカニズムを探る (2018)
  • Author(s): 森 郁恵
  • Organizer: 日本線虫学会大会公開シンポジウム “「新」線虫研究～加速する多様化と応用への期待～”
• [Presentation] Alteration between positive and negative valence of a neuronal connection shapes a C. elegans navigation behavior. (2018)
  • Author(s): Shunji Nakano, Muneki Ikeda, Yuki Tsukada, Ayana Sano, Rumi Kondo, Takamasa Suzuki, Tetsuya Higashiyama, Ikue Mori,
  • Organizer: 研究会「線虫研究の未来を創る」
• [Presentation] Basic Principles of Information Processing Extracted from Simple Neural Circuits - Towards Application to Complex Brains. (2018)
  • Author(s): 中野 俊詩
  • Organizer: 第41回日本神経科学大会シンポジウム
• [Presentation] 神経系による情報処理を、感覚入力から行動出力まで全て解明する！ (2018)
  • Author(s): 青木 一郎
  • Organizer: 研究会「線虫研究の未来を創る」
• [Presentation] Mathematical and physical ethology in C. elegans (2018)
  • Author(s): 松山 裕典
  • Organizer: 研究会「線虫研究の未来を創る」
• [Presentation] Glial regulation of sensory neurons, circuits and behavior. (2018)
  • Author(s): Ichiro Aoki
  • Organizer: 新学術領域研究グリアアセンブリ第5回班会議
• [Presentation] Learning, memory and decision-making in C. elegans thermotaxis (2018)
  • Author(s): Kondo, R., Jurado, P., Aoki, I., Nakano, S., Mori, I.
  • Organizer: 新学術領域研究「多様性から明らかにする記憶ダイナミズムの共通原理」平成29年度班会議
• [Presentation] BK potassium channels regulate learning speed in C. elegans (2017)
  • Author(s): Aoki, I., Tateyama, M., Shimomura, T., Ihara, K., Kubo, Y., Mori, I.
  • Organizer: 21st International C.elegans Conference
  • Int'l Joint Research
• [Presentation] The C. elegans MAST Kinase Acts through Stomatin and Diacylglycerol Kinase to Regulate Thermotaxis Behavior (2017)
  • Author(s): Nakano, S., Ikeda, M., Giles, A. C., Suzuki, T., Sano, A., Kondo, R., Higashiyama, T., Mori, I.
  • Organizer: 21st International C.elegans Conference
  • Int'l Joint Research
• [Presentation] Laser axotomy and optogenetics for functional analysis of ipsilateral neuronal connection at synaptic level. (2017)
  • Author(s): Tsukada, Y., Mori, I.
  • Organizer: 21st International C.elegans Conference
  • Int'l Joint Research
• [Presentation] Neural mechanisms underlying behavioral switching in thermotaxis of C. elegans. (2017)
  • Author(s): Matsuyama, J.H., Tsukada, Y., Mori, I.
  • Organizer: 21st International C.elegans Conference
  • Int'l Joint Research
• [Presentation] A glial K+/Cl- cotransporter ultimately regulates a behavior through modification of stimulus-evoked dynamics in C. elegans sensory neurons (2017)
  • Author(s): 森 郁恵
  • Organizer: 新学術領域研究「グリアアセンブリによる脳機能発現の制御と病態」第4回夏のワークショップ
• [Presentation] Identification and analysis of multifunctional neurons in a C. elegans thermotaxis behavior (2017)
  • Author(s): Ikeda, M., Nakano, S., Giles, A. C., Mori, I.
  • Organizer: 21st International C.elegans Conference
  • Int'l Joint Research
• [Presentation] BK potassium channels regulate learning speed in C. elegans (2017)
  • Author(s): Aoki, I., Tateyama, M., Shimomura, T., Ihara, K., Kubo, Y., Mori, I.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Neural mechanisms underlying behavioral switching among exploitation and exploration modes in the nematode C. elegans (2017)
  • Author(s): Matsuyama, J.H., Tsukada, Y., Mori, I.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Functional analysis of ipsilateral neuronal connection at synaptic level (2017)
  • Author(s): Tsukada, Y., Mori, I.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Information Flow through Local Neural Circuits that Integrate Sensory Input and Behavioral Output during a C. elegans Navigation Behavior (2017)
  • Author(s): Ikeda, M., Nakano, S., Giles, A. C., Mori, I.
  • Organizer: 第40回日本神経科学大会
• [Presentation] 線虫C. elegansにおける機能的神経回路の抽出と統合情報量解析 (2017)
  • Author(s): 池田 宗樹
  • Organizer: 生理研研究会2017 認知神経科学の先端 「意識の脳内メカニズム」
• [Presentation] BK potassium channels regulate learning speed in C. elegans (2017)
  • Author(s): Aoki, I., Tateyama, M., Shimomura, T., Ihara, K., Kubo, Y., Mori, I.
  • Organizer: 内藤記念科学振興財団第44回内藤コンファレンス
• [Presentation] 温度受容神経細胞のシステム同定と温度環境の再構築 (2017)
  • Author(s): 塚田祐基, 森郁恵
  • Organizer: 第60回自動制御連合講演会
• [Presentation] BK potassium channels regulate learning speed in C. elegans (2017)
  • Author(s): Aoki, I., Tateyama, M., Shimomura, T., Ihara, K., Kubo, Y., Mori, I.
  • Organizer: 第48回生理研国際シンポジウム
  • Int'l Joint Research
• [Presentation] 線虫を用いた感覚-介在神経細胞間の単一シナプスレベル機能解析 (2017)
  • Author(s): 塚田祐基, 森郁恵
  • Organizer: 2017年度 生命科学系学会合同年次大会
  • Int'l Joint Research
• [Presentation] 光駆動型細胞死誘導タンパク質miniSOGを用いた機能的神経回路の同定 (2017)
  • Author(s): Ikeda, M., Nakano, S., Giles, A. C., Mori, I.
  • Organizer: 第9回光操作研究会
• [Presentation] Neural mechanisms underlying behavioral switching among exploitation and exploration modes in the nematode C.elegans. (2017)
  • Author(s): Matsuyama J. H., Tsukada Y., Tsukamoto S., Yamao M., Honda N., Ishii S, Mori I.
  • Organizer: 定量生物学の会 第8回年会
• [Presentation] 線虫行動と神経回路の包括的解析から記憶、学習、意思決定のメカニズムを探る (2016)
  • Author(s): 森郁恵
  • Organizer: 第34回日本生理心理学大会
  • Invited
• [Presentation] Unveiling principle of neural circuits underlying learning, memory, and decision-making. (2016)
  • Author(s): Ikue Mori
  • Organizer: Science Lecture at Department of Life Science, Pekin University
  • Invited
• [Presentation] Local Neural Circuits Integrating Sensory Input and Behavioral Output during a C. elegans Navigation Behavior (2016)
  • Author(s): Ikeda M., Nakano S., Giles A. C., Mori I.
  • Organizer: 第39回日本神経科学大会
• [Presentation] Epilepsy -related mutations in SLO-2 BK potassium channel slow down a behavior change in C.elegans (2016)
  • Author(s): Aoki I., Ihara K., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] Toward functional connectomics at synaptic level (2016)
  • Author(s): Tsukada Y., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] Switching among exploitation and exploration behavioral modes in the nematode C. elegans (2016)
  • Author(s): Matsuyama J. H., Tsukada Y., Tsukamoto S., Yamao M., Honda N., Ishii S., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] Integration of thermal and chemical information in C.elegans (2016)
  • Author(s): Kano A., Tsukada Y., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] Identification of RIA interneuron-mediated behavioral components essential for thermotaxis (2016)
  • Author(s): Xu L., Tsukada Y., Ikeda M., Nakano S., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] The C. elegans MAST Kinase Acts through Stomatin to Regulate Thermotaxis Behavior (2016)
  • Author(s): Nakano S., Ikeda M., A. C. Giles, Suzuki T., Sano A., Kondo R., Shiota M., Higasihiyama T., Mori I.
  • Organizer: C. elegans Topic Meeting CeNeuro 2016
  • Int'l Joint Research
• [Presentation] Epilepsy -related mutations in SLO-2 K+ channel slow down learning speed in C.elegans (2016)
  • Author(s): Aoki I., Tateyama M., Shimomura T., Ihara K., Mori I.
  • Organizer: 生理学研究所国際研究集会" Towards elucidation of memory engram"
  • Int'l Joint Research
• [Remarks] Group of Molecular Neurobiology,Nagoya University
  • URL: http://elegans.bio.nagoya-u.ac.jp/~lab/index.html
• [Remarks] Nagoya University Neuroscience Institute
  • URL: https://nsi.bio.nagoya-u.ac.jp/en/