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Development of regenerative medicine for chronic pain: novel treatment with cell transplantation and drug delivery system.

Research Project

Project/Area Number 16H02678
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology
Research InstitutionGunma University

Principal Investigator

SAITO SHIGERU  群馬大学, 大学院医学系研究科, 教授 (40251110)

Co-Investigator(Kenkyū-buntansha) 荻野 祐一  群馬大学, 医学部附属病院, 講師 (20420094)
高澤 知規  群馬大学, 医学部附属病院, 講師 (30400766)
田畑 泰彦  京都大学, ウイルス・再生医科学研究所, 教授 (50211371)
須藤 貴史  群馬大学, 医学部附属病院, 講師 (60739621)
久保 和宏  群馬大学, 大学院医学系研究科, 助教 (80546531)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2016: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords慢性疼痛 / 再生医療 / 抑制ニューロン / 脊髄後角 / 神経障害性疼痛 / 慢性痛
Outline of Final Research Achievements

Pain and impaired endogenous analgesia are risk factors of chronic postsurgical persistent pain (CPSP). A Chronic neuropathic pain model induced by spinal nerve ligation shows impaired endogenous analgesia and delayed recovery from incisional pain. Repeated pharmacological treatment can restore the endogenous analgesia, but its effects on delayed recovery are not clear.
In this research project, several animal chronic painful practices including plantar incision were made on the side uni- and contralateral to the nerve ligation in chronic pain rats. Withdrawal thresholds were measured by pain assessment standards, such as von Frey filament test until 28 d after surgery. Among several tested drugs, amitriptyline (10 mg·kg-1·d-1) was considered effective for 13 d perioperatively. To examine the roles of noradrenergic and cholinergic signals in the spinal dorsal horn,

Academic Significance and Societal Importance of the Research Achievements

本研究により、末梢神経障害性の痛みでは下行性制御系の活動が重要である事が再確認されたことは痛みメカニズムの解明に寄与したと考えられる。また、抗てんかん薬、抗ケイレン薬系統の薬剤による慢性痛治療を更に有効にするための基礎データを得ることができた

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (9 results)

All 2020 2019 2018 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 5 results)

  • [Journal Article] Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain2020

    • Author(s)
      Ohta J, Suto T, Kato D, Hiroki T, Obata H, Saito
    • Journal Title

      Brain Res

      Volume: 1727 Pages: 146568-146568

    • DOI

      10.1016/j.brainres.2019.146568

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats2019

    • Author(s)
      Suto T, Kato D, Obata H, Saito S
    • Journal Title

      J Pain

      Volume: 20 Issue: 5 Pages: 600-609

    • DOI

      10.1016/j.jpain.2018.11.008

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploring the Neural Correlates in Adopting a Realistic View: A Neural Structural and Functional Connectivity Study With Female Nurses2019

    • Author(s)
      Ogino Yuichi、Kawamichi Hiroaki、Kakeda Takahiro、Saito Shigeru
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 13 Pages: 197-197

    • DOI

      10.3389/fnhum.2019.00197

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prosocial behavior toward estranged persons modulates the interaction between midline cortical structures and the reward system2018

    • Author(s)
      Kawamichi Hiroaki、Sugawara Sho K.、Hamano Yuki H.、Makita Kai、Kochiyama Takanori、Kikuchi Yoshiaki、Ogino Yuichi、Saito Shigeru、Sadato Norihiro
    • Journal Title

      Social Neuroscience

      Volume: in press Issue: 5 Pages: 618-630

    • DOI

      10.1080/17470919.2018.1553797

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sustained-release lidocaine sheet for pain following tooth extraction: A randomized, single-blind, dose-response, controlled, clinical study of efficacy and safety2018

    • Author(s)
      Suzuki Toshiyuki、Kosugi Kensuke、Suto Takashi、Tobe Masaru、Tabata Yasuhiko、Yokoo Satoshi、Saito Shigeru
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: e0200059-e0200059

    • DOI

      10.1371/journal.pone.0200059

    • NAID

      120006491841

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spinal activation of tropomyosin receptor kinase-B recovers the impaired endogenous analgesia in neuropathic pain rats2018

    • Author(s)
      Kato D, Suto T, Obata H, Saito S
    • Journal Title

      Anesth Analg

      Volume: 印刷中 Issue: 2 Pages: 578-586

    • DOI

      10.1213/ane.0000000000003592

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The history and progress of local anesthesia: multiple approaches to elongate the action.2018

    • Author(s)
      Tobe M, Suto T, Saito S
    • Journal Title

      J Anesth.

      Volume: Aug;32(4) Issue: 4 Pages: 632-636

    • DOI

      10.1007/s00540-018-2514-8

    • NAID

      40021627022

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain morphological alternation in chronic pain patients with neuropathic characteristics.2016

    • Author(s)
      Sugimine S, Ogino Y, Kawamichi H, Obata H, Saito S.
    • Journal Title

      Free PMC Article

      Volume: 12 Pages: 1-7

    • DOI

      10.1177/1744806916652408

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats.2016

    • Author(s)
      Matsuoka H, Suto T, Saito S, Obata H.
    • Journal Title

      Anesthesia & Analgesia

      Volume: August Pages: 504-510

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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