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Molecular analysis and delineation of the mechanisms underlying progression of urogenital cancers and alteration of tumor immuno-microenvironment associated with adiposity enhancement

Research Project

Project/Area Number 16H02679
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionAkita University

Principal Investigator

Habuchi Tomonori  秋田大学, 医学系研究科, 教授 (00293861)

Co-Investigator(Kenkyū-buntansha) 南條 博  秋田大学, 医学部附属病院, 准教授 (70250892)
土谷 順彦  山形大学, 医学部, 教授 (70282176)
大山 力  弘前大学, 医学研究科, 教授 (80282135)
沼倉 一幸  秋田大学, 医学系研究科, 助教 (90566415)
前野 淳  秋田大学, 医学部, 助教 (10759236)
Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords高脂肪食 / 肥満 / adiposity / 前立腺癌 / 腎癌 / 腫瘍微小環境 / サイトカイン / ホスホイノシタイド / 高脂肪 / 腫瘍微少環境 / microbiota / GFRAL / 腫瘍免疫 / FABP-4 / adipokine / microRNA / 腎細胞癌 / 脂質
Outline of Final Research Achievements

The incidence of urologic cancers has been increasing dramatically. The increase is suggested to be caused by the prevalent high-caloric, high-fat diet. Now, cancer progression is believed to be caused not only by the nature of cancer cells but also greatly influenced by the patient’s systemic immunological conditions, and immune cells and liquid factors in tumor microenvironment.
Purpose: To identify and clarify the significant factors in tumor immuno-microenvironment influencing the cancer progression caused by the excessive adiposity condition, by extensively analyzing the lipids, liquid factors and tumor microenvironment immune cells. Results: FABP4 and MIC-1 were shown to be strongly involved in prostate cancer progression by enhancing and stimulating tumor interstitial cells and immune-modifying liquid factors. Furthermore, the component of phosphoinositides, biologically important phospholipids, was shown to be altered in prostate cancer cells compared with normal prostate.

Academic Significance and Societal Importance of the Research Achievements

脂質代謝に関与するFABP4 and MIC-1が間質細胞などを刺激して、腫瘍促進因子であるIL-6、IL-8などを過剰発現させることで腫瘍進展に関与していることが判った。これらの制御分子や抗体が今後の癌治療の標的分子の有力候補となる。またこれらは腫瘍微小環境における免疫機能に関与していることから、免疫療法の反応性にも関与している可能性があり、今後、解明すべき重要課題である。
さらにホスホイノシタイドの構成変化が癌進展に関与していることが強く示唆されたことより、この構成や量を制御することが、癌の発生や進展阻止につながるかは、その制御法や新規制御物質も含めて癌予防や治療に大きなインパクトを持つ。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (59 results)

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article (34 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 33 results,  Open Access: 23 results,  Acknowledgement Compliant: 4 results) Presentation (20 results) (of which Int'l Joint Research: 11 results) Remarks (5 results)

  • [Journal Article] Macrophage inhibitory cytokine‐1 induced by a high‐fat diet promotes prostate cancer progression by stimulating tumor‐promoting cytokine production from tumor stromal cells2021

    • Author(s)
      Huang Mingguo、Narita Shintaro、Koizumi Atsushi、Nara Taketoshi、Numakura Kazuyuki、Satoh Shigeru、Nanjo Hiroshi、Habuchi Tomonori
    • Journal Title

      Cancer Communications

      Volume: 41 Issue: 5 Pages: 389-403

    • DOI

      10.1002/cac2.12137

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term outcomes of risk-adapted upfront docetaxel administration in patients with metastatic hormone-sensitive prostate cancer: a multicenter prospective study in Japan2021

    • Author(s)
      Muto Yumina、Narita Shintaro、Hatakeyama Shingo、Maita Shinya、Chiba Shuji、Kubo Kyohei、Aoyama Yuu、Ito Ryuichi、Takahashi Yoshiko、Takahashi Shuhei、Nakamura Kumiko、Honma Naoko、Sato Hiromi、Ohyama Chikara、Habuchi Tomonori
    • Journal Title

      Medical Oncology

      Volume: 38 Issue: 4 Pages: 37-37

    • DOI

      10.1007/s12032-021-01480-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between missense polymorphisms in SRD5A2 and HSD3B1 and treatment failure with abiraterone for castration-resistant prostate cancer2021

    • Author(s)
      Shiota Masaki、Akamatsu Shusuke、Narita Shintaro、Sumiyoshi Takayuki、Fujiwara Maki、Uchiumi Takeshi、Ogawa Osamu、Habuchi Tomonori、Eto Masatoshi
    • Journal Title

      The Pharmacogenomics Journal

      Volume: 1 Issue: 4 Pages: 1-1

    • DOI

      10.1038/s41397-021-00220-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of the combined androgen blockade therapy versus luteinizing hormone-releasing hormone analog monotherapy in patients with hormone naive metastatic prostate cancer: a multi-institutional comparative analysis2021

    • Author(s)
      Narita Takuma、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Shimoda Jiro、Kawaguchi Toshiaki、Ishidoya Shigeto、Mitsuzuka Koji、Arai Yoichi、Ito Akihiro、Tsuchiya Norihiko、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      Translational Andrology and Urology

      Volume: 10 Issue: 1 Pages: 417-425

    • DOI

      10.21037/tau-20-966

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model2021

    • Author(s)
      Narita Shintaro、Obara Takashi、Ishikawa Namiko、Suzuki Yoshihisa、Habuchi Tomonori
    • Journal Title

      Sexual Medicine

      Volume: 9 Issue: 1 Pages: 100308-100308

    • DOI

      10.1016/j.esxm.2020.100308

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Impact of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma receiving systemic tyrosine kinase inhibitor therapy: A multicenter retrospective study2020

    • Author(s)
      Hatakeyama Shingo、Naito Sei、Numakura Kazuyuki、Kato Renpei、Koguchi Tomoyuki、Kojima Takahiro、Kawasaki Yoshihide、Kandori Shuya、Kawamura Sadafumi、Tsushima Eiki、Nishiyama Hiroyuki、Ito Akihiro、Kojima Yoshiyuki、Habuchi Tomonori、Obara Wataru、Tsuchiya Norihiko、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 4 Pages: 369-375

    • DOI

      10.1111/iju.14466

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does the Addition of Abiraterone to Castration Affect the Reduction in Bone Mineral Density?2020

    • Author(s)
      NAKAJIMA SHIORI、INOUE TAKAMITSU、HUANG MINGGUO、TAKAYAMA KOICHIRO、KASHIMA SOKI、YAMAMOTO RYOHEI、KOIZUMI ATSUSHI、NARA TAKETOSHI、NUMAKURA KAZUYUKI、SAITO MITSURU、NARITA SHINTARO、MIURA MASATOMO、SATOH SHIGERU、HABUCHI TOMONORI
    • Journal Title

      In Vivo

      Volume: 34 Issue: 6 Pages: 3291-3299

    • DOI

      10.21873/invivo.12167

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of plasminogen activator inhibitor‐1 in biomarker exploration using multiplex immunoassay in patients with metastatic renal cell carcinoma treated with axitinib2020

    • Author(s)
      Honma Naoko、Inoue Takamitsu、Tsuchiya Norihiko、Koizumi Atsushi、Yamamoto Ryohei、Nara Taketoshi、Kanda Sohei、Huang Mingguo、Numakura Kazuyuki、Saito Mitsuru、Narita Shintaro、Satoh Shigeru、Habuchi Tomonori
    • Journal Title

      Health Science Reports

      Volume: 3 Issue: 4 Pages: 197-197

    • DOI

      10.1002/hsr2.197

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validated prognostic significance of YB-1 genetic variation in metastatic prostate cancer2020

    • Author(s)
      Shiota Masaki、Narita Shintaro、Habuchi Tomonori、Eto Masatoshi
    • Journal Title

      The Pharmacogenomics Journal

      Volume: 21 Issue: 1 Pages: 102-105

    • DOI

      10.1038/s41397-020-00188-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of tumor burden with the eligibility of upfront intensification therapy in metastatic castration‐sensitive prostate cancer: A multicenter retrospective study2020

    • Author(s)
      Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Hamano Itsuto、Okamoto Teppei、Mitsuzuka Koji、Ito Akihiro、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 27 Issue: 7 Pages: 610-617

    • DOI

      10.1111/iju.14258

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Nuclear YAP1 Expression in Residual Cancer After Neoadjuvant Chemohormonal Therapy With Docetaxel for High-Risk Localized Prostate Cancer2020

    • Author(s)
      Yoshinori Matsuda, Shintaro Narita, Taketoshi Nara, Huang Mingguo, Hiromi Sato, Atsushi Koizumi, Sohei Kanda, Kazuyuki Numakura, Mitsuru Saito, Takamitsu Inoue, Yuko Hiroshima, Hiroshi Nanji, Shigeru Satoh, Norihiko Tsuchiya, Tomonori Habuchi
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 2034-2034

    • DOI

      10.1186/s12885-020-06844-y

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Salvage Radiotherapy Versus Hormone Therapy for Prostate-specific Antigen Failure After Radical Prostatectomy: A Randomised, Multicentre, Open-label, Phase 3 Trial (JCOG0401)†2020

    • Author(s)
      Yokomizo Akira、Wakabayashi Masashi、Satoh Takefumi、Hashine Katsuyoshi、Inoue Takahiro、Fujimoto Kiyohide、Egawa Shin、Habuchi Tomonori、Kawashima Kiyotaka、Ishizuka Osamu、Shinohara Nobuo、Sugimoto Mikio、Yoshino Yasushi、Nihei Keiji、Fukuda Haruhiko、Tobisu Ken-ichi、Kakehi Yoshiyuki、Naito Seiji
    • Journal Title

      European Urology

      Volume: 77 Issue: 6 Pages: 689-698

    • DOI

      10.1016/j.eururo.2019.11.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic T lymphocytes regenerated from iPS cells have therapeutic efficacy in a patient-derived xenograft solid tumor model.2020

    • Author(s)
      Kashima S, Maeda T, Masuda K, Nagano S, Inoue T, Takeda M, Kono Y, Kobayashi T, Saito S, Higuchi T, Ichise H, Kobayashi Y, Iwaisako K, Terada K, Agata Y, Nakamura K, Saito M, Narita S, Ogawa O, Habuchi T, Kawamoto H.
    • Journal Title

      iScience

      Volume: 23 Issue: 4 Pages: 100998-100998

    • DOI

      10.1016/j.isci.2020.100998

    • NAID

      120006826710

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in PCSK9 and LDL cholesterol concentrations by everolimus treatment and their effects on polymorphisms in PCSK9 and mTORC12020

    • Author(s)
      Sato S, Akamine Y, Kagaya H, Saito M, Inoue T, Numakura K, Habuchi T, Satoh S, Miura M
    • Journal Title

      Pharmacol Rep

      Volume: 1 Issue: 3 Pages: 1-1

    • DOI

      10.1007/s43440-020-00090-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the "Liquid Autopsy".2020

    • Author(s)
      Ito Y, Yoshida M, Inoue T, Habuchi T, Ikoma S, Katoh H, Kato M, Shibata T, Ishikawa S, Yachida S, Goto A.
    • Journal Title

      Sci Rep

      Volume: 10(1) Issue: 1 Pages: 2120-2120

    • DOI

      10.1038/s41598-020-59193-y

    • NAID

      120007089050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression2019

    • Author(s)
      Koizumi Atsushi、Narita Shintaro、Nakanishi Hiroki、Ishikawa Masaki、Eguchi Satoshi、Kimura Hirotaka、Takasuga Shunsuke、Huang Mingguo、Inoue Takamitsu、Sasaki Junko、Yoshioka Toshiaki、Habuchi Tomonori、Sasaki Takehiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 13257-13257

    • DOI

      10.1038/s41598-019-49744-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion.2019

    • Author(s)
      Numakura K, Nara T, Kanda S, Saito M, Narita S, Inoue T, Habuchi T.
    • Journal Title

      Front Endocrinol (Lausanne).

      Volume: 10 Pages: 572-572

    • DOI

      10.3389/fendo.2019.00572

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Research Evidence on High-Fat Diet-Induced Prostate Cancer Development and Progression2019

    • Author(s)
      Narita S, Nara T, Sato H, et al.
    • Journal Title

      J Clin Med.

      Volume: 8 Issue: 5 Pages: 597-597

    • DOI

      10.3390/jcm8050597

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of early changes in serum biomarker levels in patients with newly diagnosed metastatic prostate cancer.2019

    • Author(s)
      Narita S, Nomura K, Hatakeyama S, Takahashi M, Sakurai T, Kawamura S, Hoshi S, Ishida M, Kawaguchi T, Ishidoya S, Shimoda J, Sato H, Mitsuzuka K, Tochigi T, Tsuchiya N, Ohyama C, Arai Y, Nagashima K, Habuchi T
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 12071-12071

    • DOI

      10.1038/s41598-019-48600-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone2019

    • Author(s)
      Shiota Masaki、Narita Shintaro、Akamatsu Shusuke、Fujimoto Naohiro、Sumiyoshi Takayuki、Fujiwara Maki、Uchiumi Takeshi、Habuchi Tomonori、Ogawa Osamu、Eto Masatoshi
    • Journal Title

      JAMA Network Open

      Volume: 2 Issue: 2 Pages: e190115-e190115

    • DOI

      10.1001/jamanetworkopen.2019.0115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients2019

    • Author(s)
      Terada Naoki、Kamoto Toshiyuki、Tsukino Hiromasa、Mukai Shoichiro、Akamatsu Shusuke、Inoue Takahiro、Ogawa Osamu、Narita Shintaro、Habuchi Tomonori、et al.
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 156-156

    • DOI

      10.1186/s12885-019-5342-9

    • NAID

      120006709422

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patients with metastatic renal cell carcinoma who benefit from axitinib dose titration: analysis from a randomised, double-blind phase II study2019

    • Author(s)
      Tomita Yoshihiko、Uemura Hirotsugu、Oya Mototsugu、Shinohara Nobuo、Habuchi Tomonori、Fujii Yosuke、Kamei Yoichi、Umeyama Yoshiko、Bair Angel H.、Rini Brian I.
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s12885-018-5224-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radical Prostatectomy With and Without Neoadjuvant Chemohormonal Pretreatment for High-Risk Localized Prostate Cancer: A Comparative Propensity Score Matched Analysis2019

    • Author(s)
      Narita Shintaro、Nara Taketoshi、Kanda Sohei、Numakura Kazuyuki、Saito Mitsuru、Inoue Takamitsu、Satoh Shigeru、Nanjo Hiroshi、Tsuchiya Norihiko、Mitsuzuka Koji、Koie Takuya、Kawamura Sadafumi、Ohyama Chikara、Tochigi Tatsuo、Arai Yoichi、Habuchi Tomonori
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 17 Issue: 1 Pages: e113-e122

    • DOI

      10.1016/j.clgc.2018.09.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of nutritional status on the prognosis of patients with metastatic hormone-na?ve prostate cancer: a multicenter retrospective cohort study in Japan2018

    • Author(s)
      Okamoto Teppei、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Mitsuzuka Koji、Tochigi Tatsuo、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      World Journal of Urology

      Volume: 99 Issue: 9 Pages: 000-0001

    • DOI

      10.1007/s00345-018-2590-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical implications of pharmacokinetics of sunitinib malate and N-desethyl-sunitinib plasma concentrations for treatment outcome in metastatic renal cell carcinoma patients2018

    • Author(s)
      Numakura Kazuyuki、Fujiyama Nobuhiro、Takahashi Makoto、Igarashi Ryoma、Tsuruta Hiroshi、Maeno Atsushi、Huang Mingguo、Saito Mitsuru、Narita Shintaro、Inoue Takamitsu、Satoh Shigeru、Tsuchiya Norihiko、Niioka Takenori、Miura Masatomo、Habuchi Tomonori
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 38 Pages: 25277-25284

    • DOI

      10.18632/oncotarget.25423

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of early changes in serum biomarkers following androgen deprivation therapy on clinical outcomes in metastatic hormone-sensitive prostate cancer2018

    • Author(s)
      Sato Hiromi、Narita Shintaro、Tsuchiya Norihiko、Koizumi Atsushi、Nara Taketoshi、Kanda Sohei、Numakura Kazuyuki、Tsuruta Hiroshi、Maeno Atsushi、Saito Mitsuru、Inoue Takamitsu、Satoh Shigeru、Nomura Kyoko、Habuchi Tomonori
    • Journal Title

      BMC Urology

      Volume: 18 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s12894-018-0353-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of UGT1A1 genetic polymorphisms related to axitinib pharmacokinetics to safety and efficacy in patients with renal cell carcinoma.2018

    • Author(s)
      Igarashi R, Inoue T, Fujiyama N, Tsuchiya N, Numakura K, Kagaya H, Saito M, Narita S, Satoh S, Niioka T, Miura M, Habuchi T.
    • Journal Title

      Med Oncol.

      Volume: 35(51) Issue: 4 Pages: 51-58

    • DOI

      10.1007/s12032-018-1113-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production2017

    • Author(s)
      Huang Mingguo、Narita Shintaro、Inoue Takamitsu、Koizumi Atsushi、Saito Mitsuru、Tsuruta Hiroshi、Numakura Kazuyuki、Satoh Shigeru、Nanjo Hiroshi、Sasaki Takehiko、Habuchi Tomonori
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 67 Pages: 111780-111794

    • DOI

      10.18632/oncotarget.22908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K2017

    • Author(s)
      Malek M、Kielkowska A、Chessa T、Anderson K E.、Barneda D、Pir P、Nakanishi H、Eguchi S、Koizumi A、Sasaki J、Juvin V、Kiselev VY.、Niewczas I、Gray A、Valayer A、Spensberger D、Imbert M、Felisbino S、Habuchi T、Beinke S、Cosulich S、Le Novere N、Sasaki T、Clark J、Hawkins PT.、Stephens LR.
    • Journal Title

      Molecular Cell

      Volume: 68 Issue: 3 Pages: 566-580

    • DOI

      10.1016/j.molcel.2017.09.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inverse relationship between insulin receptor expression and progression in renal cell carcinoma.2017

    • Author(s)
      Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Habuchi T.
    • Journal Title

      Oncol Rep.

      Volume: 37 Issue: 5 Pages: 2929-2941

    • DOI

      10.3892/or.2017.5552

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibition of the RANK/RANKL signaling with osteoprotegerin prevents castration-induced acceleration of bone metastasis in castration-insensitive prostate cancer2017

    • Author(s)
      1)Takayama K, Inoue T, Narita S, Maita S, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Satoh S, Tsuchiya N, Habuchi T
    • Journal Title

      Cancer Letters

      Volume: in press Pages: 103-110

    • DOI

      10.1016/j.canlet.2017.03.034

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the "obesity paradox".2017

    • Author(s)
      Ito R, Narita S, Huang M, Nara T, Numakura K, Takayama K, Tsuruta H, Maeno A, Saito M, Inoue T, Tsuchiya N, Satoh S, Habuchi T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 2 Pages: e0171615-e0171615

    • DOI

      10.1371/journal.pone.0171615

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altered miRNA expression in high-fat diet-induced prostate cancer progression.2016

    • Author(s)
      Nara T, Narita S, Mingguo H, Yoshioka T, Koizumi A, Numakura K, Tsuruta H, Maeno A, Saito M, Inoue T, Tsuchiya N, Satoh S, Habuchi T
    • Journal Title

      Carcinogenesis

      Volume: 37 Pages: 1129-1137

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples.2016

    • Author(s)
      7)Kurobe M, Kojima T, Nishimura K, Kandori S, Kawahara T, Yoshino T, Ueno S, Iizumi Y, Mitsuzuka K, Arai Y, Tsuruta H, Habuchi T, Kobayashi T, Matsui Y, Ogawa O, Sugimoto M, Kakehi Y, Nagumo Y, Tsutsumi M, Oikawa T, Kikuchi K, Nishiyama H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 12 Pages: e0165109-e0165109

    • DOI

      10.1371/journal.pone.0165109

    • NAID

      120005980906

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ホスホイノシタイド(PIPs)プロファイルと前立腺癌の関連検討2019

    • Author(s)
      小泉 淳, 成田伸太郎, 中西広樹, 奈良健平, 千葉修治, 神田壮平, 沼倉一幸, 黄 明国, 齋藤 満, 井上高光, 佐藤 滋, 吉岡年明, 羽渕友則, 佐々木雄彦
    • Organizer
      2第28回泌尿器分子細胞研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ホスホイノシタイド(PIPs)プロファイルと前立腺癌の関連検討2019

    • Author(s)
      小泉 淳, 成田伸太郎, 中西広樹, 千葉修治, 神田壮平, 沼倉一幸, 黄 明国, 齋藤 満, 井上高光, 佐藤 滋, 吉岡年明, 羽渕友則, 佐々木雄彦
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] iPS細胞技術を用いたWT1抗原特異的再生キラーT細胞の腎細胞癌に対する抗腫瘍効果2019

    • Author(s)
      嘉島相輝, 前田卓也, 永野誠治, 増田喬子, 井上高光, 安川正貴, 小林 恭, 山﨑俊成, 小川 修, 羽渕友則, 河本 宏
    • Organizer
      第23回日本がん免疫学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] HFD leads to metabolic modification of prostate cancer promoting stroma by the upregulation of MIC-12019

    • Author(s)
      Huang, M., Narita, S., Koizumi, A., Nara, T., Numakura, K., Satoh, S., Nanjo, H., Habuchi, T.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma2019

    • Author(s)
      Narita, S., Nakanishi, H., Matsuda, Y., Koizumi, A., Eguchi, S., Takasuga, S., Huang, M., Inoue, T., Sasaki, J., Nanjo, H., Habuchi, T., Sasaki, T.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] MACROPHAGE INHIBITORY CYTOKINE-1 STIMULATES STROMAL CYTOKINE PRODUCTION IN HIGH-FAT DIET-INDUCED PROSTATE CANCER PROGRESSION2018

    • Author(s)
      Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMPARISON WITH DIAGNOSTIC PERFORMANCE BETWEEN ABERRANT GLYCOSYLATED S2,3PSA TEST AND CONVENTIONAL PSA TESTS2018

    • Author(s)
      Tohru Yoneyama, Tomokazu Ishikawa, Tomonori Habuchi, et al.
    • Organizer
      Annual Meeting of American Urological Association 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BRAF V600E MUTATION PROMOTED EXCESS OF HORMONE AND TUMORIGENESIS IN ADRENAL CORTICAL ADENOMA WITH AUTONOMOUS CORTISOL SECRETION2018

    • Author(s)
      Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Shigeru Satoh, Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] INFLUENCE OF POLYMORPHISM IN VASCULAR ENDOTHELIAL-RELATED GENES ON CLINICAL RESPONSE TO AXITINIB IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA2018

    • Author(s)
      Kazuyuki Numakura, Ryoma Igarashi, Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MACROPHAGE INHIBITORY CYTOKINE-1 STIMULATES STROMAL CYTOKINE PRODUCTION IN HIGH-FAT DIET-INDUCED PROSTATE CANCER PROGRESSION2018

    • Author(s)
      Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Tomonori Habuchi
    • Organizer
      2018 Annual Meeting of American Urological Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BRAF V600E MUTATION PROMOTED EXCESS OF HORMONE AND TUMORIGENESIS IN ADRENAL CORTICAL ADENOMA WITH AUTONOMOUS CORTISOL SECRETION2018

    • Author(s)
      Kazuyuki Numakura, Taketoshi Nara, Sohei Kanda, Hiroshi Tsuruta, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Shigeru Satoh, Tomonori Habuchi
    • Organizer
      2018 Annual Meeting of American Urological Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高脂肪食による前立腺癌間質活性化と前立腺癌進展におけるMIC-1の役割2018

    • Author(s)
      黄明国、成田伸太郎、井上高光、羽渕友則
    • Organizer
      第106回 日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高脂肪食摂取下前立腺癌進展における前立腺癌微小環境とMIC-1の関連2018

    • Author(s)
      黄明国、成田伸太郎、井上高光、羽渕友則
    • Organizer
      第27回 泌尿器科分子細胞研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] THE ROLE OF FATTY ACID BINDING PROTEIN 4 IN PROSTATE STROMAL TUMOR MICROENVIRONMENT AND PROSTATE CANCER PROGRESSION2017

    • Author(s)
      Mingguo Huang, Atsushi Koizumi, Takamitsu Inoue, Shintaro Narita, Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2017
    • Place of Presentation
      Boston, USA
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PURE HOST-RELATED RISK FACTORS FOR ADHERENT PERINEPHRIC FAT IN HEALTHY INDIVIDUALS DURING LAPAROSCOPIC RENAL SURGERY2017

    • Author(s)
      Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Taketoshi Nara, Koichiro Takayama, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, and Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2017
    • Place of Presentation
      Boston, USA
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PROTECTIVE EFFECTS OF REGULATORY T CELLS IN A MURINE MODEL OF RENAL ISCHEMIA-REPERFUSION INJURY2017

    • Author(s)
      Ryohei Yamamoto, Mitsuru Saito, Kazuyuki Numakura, Hiroshi Tsuruta, Atushi Maeno, Takamitsu Inoue, Shintaro Narita, Shigeru Satoh, and Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2017
    • Place of Presentation
      Boston, USA
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CLINICAL IMPLICATIONS OF SUNITINIB AND N-DESETHYL-SUNITINIB PLASMA CONCENTRATIONS FOR TREATMENT OUTCOME IN METASTATIC RENAL CELL CARCINOMA PATIENTS2017

    • Author(s)
      Kazuyuki Numakura, Nobuhiro Fujiyama, Makoto Takahashi, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, and Tomonori Habuchi
    • Organizer
      Annual Meeting of American Urological Association 2017
    • Place of Presentation
      Boston, USA
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] THE ROLE OF FATTY ACID BINDING PROTEIN 4 IN PROSTATE STROMAL TUMOR MICROENVIRONMENT AND PROSTATE CANCER PROGRESSION2017

    • Author(s)
      Mingguo Huang, Atsushi Koizumi, Takamitsu Inoue, Shintaro Narita, Tomonori Habuchi
    • Organizer
      2017 Annual Meeting of American Urological Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高脂肪食による前立腺癌間質活性化と前立腺癌進展2017

    • Author(s)
      黄明国、成田伸太郎、井上高光、小泉淳、羽渕友則
    • Organizer
      第5回がんと代謝 研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HFD modifies prostate cancer microenvironment and enhance cancer progression2017

    • Author(s)
      黄明国、成田伸太郎、井上高光、小泉淳、羽渕友則
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学

    • URL

      https://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学 HP

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学 HP 研究/業績

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/researcher/researchresults/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科 腎泌尿器科学講座

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-01-27  

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