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Development and clinical application research of new preventive treatment method by neuropeptide PACAP for brain and spinal cord injury.

Research Project

Project/Area Number 16H02684
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionHoshi University

Principal Investigator

Shioda Seiji  星薬科大学, 先端生命科学研究所, 教授 (80102375)

Co-Investigator(Kenkyū-buntansha) 竹ノ谷 文子  星薬科大学, 薬学部, 准教授 (30234412)
中町 智哉  富山大学, 学術研究部理学系, 講師 (30433840)
亀井 淳三  星薬科大学, 薬学部, 教授 (40161236)
宮田 篤郎  鹿児島大学, 医歯学域医学系, 教授 (60183969)
土肥 謙二  昭和大学, 医学部, 教授 (20301509)
Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2020: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2019: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
KeywordsPACAP / 神経ペプチド / 神経細胞死 / 神経再生 / 神経新生 / 脳虚血 / 脊 髄損傷 / PAC1-R / マウス / マーモセット / 脊髄損傷 / 神経細胞死防御 / 神経損傷の防御 / トランスレーショナルリサーチ / ヒト骨髄間葉系幹細胞 / 脳梗塞 / 臨床応用研究 / 遅発性神経細胞死 / 軸索伸長 / CRMP2 / トランスレーショナルリサーチ
Outline of Final Research Achievements

Though the preparation of the KO-mouse of PAC1 receptor which is directly concerned in the delayed neuronal death was possible, there are many individuals who die immediately after the birth, and it is necessary to increase the number of individuals.
It was proven that the intrinsic PACAP suppressed the delayed neuronal death of the hippocampus in the animal experiment using PACAP KO mouse, and it was also concerned in nerve regeneration and newborn. In addition, it was also clarified that PACAP manifested CRMP2 which is the axon extension factor in the culture experiment, and that it promotes the axon extension through NrdA1 which is the transcription factor. However, primate marmosets are not suitable for purpose because animals cannot increase a small number of animals. Morever, the superagonist of PAC1R is being searched at present.

Academic Significance and Societal Importance of the Research Achievements

本研究では、PACAPという神経ペプチドが遅発性神経細胞死を抑制する分子制御機構を明らかにした。さらにこのペプチドは海馬において神経細胞の再生や新生を促進することも明らかにした。脊髄損傷モデル動物においてPACAPは神経細胞死の抑制のみならず軸索伸張を起こさせて運動機能を回復させることを実証できた。このことから、PACAPは将来ヒトでの臨床応用も可能ではないかと考えられる。しかし、ペプチドには半減期が短いことなど臨床応用をするにあたり問題点もあり、最終的にはスーパーアゴニストの探索や化学合成などが必要であろう。今後さらに本研究を発展させることで多くの尊い人命救助ができる可能性が高い。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (118 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (45 results) (of which Int'l Joint Research: 18 results,  Peer Reviewed: 45 results,  Open Access: 32 results,  Acknowledgement Compliant: 6 results) Presentation (59 results) (of which Int'l Joint Research: 9 results,  Invited: 14 results) Book (6 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Attenuation of relaxing response induced by pituitary adenylate cyclase-activating polypeptide in bronchial smooth muscle of experimental asthma.2020

    • Author(s)
      Chiba Y, Ueda C, Kohno N, Yamashita M, Miyakawa Y, Ando Y, Suto W, Hirabayashi T, Takenoya F, Takasaki I, Kamei J, Sakai H, Shioda S.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol.

      Volume: 319 Issue: 5 Pages: L786-L793

    • DOI

      10.1152/ajplung.00315.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excessive folic acid supplementation in pregnant mice impairs insulin secretion and induces the expression of genes associated with fatty liver in their offspring.2020

    • Author(s)
      Kintaka Y, Wada N, Shioda S, Nakamura S, Yamazaki Y, Mochizuki K.
    • Journal Title

      Heliyon

      Volume: 18:6(4) Issue: 4 Pages: 1-8

    • DOI

      10.1016/j.heliyon.2020.e03597

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptomics of Mature Rice (Oryza Sativa L. Koshihikari) Seed under Hot Conditions by DNA Microarray Analyses.2020

    • Author(s)
      Bakku, RK, Rakwal R, Shibato J, Cho K, , Kikuchi S, Yonekura M, Sarkar A, Shioda S, Agrawal GK.
    • Journal Title

      atmosphere

      Volume: 11 Issue: 5 Pages: 528-528

    • DOI

      10.3390/atmos11050528

    • NAID

      120007146562

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA Microarray-Bioinformatics Based Analysis of PACAP38 Neuroprotective Effect on Ischemic Brain Suggests Differential Molecular Signaling Pathways Involved in GSK3β and CRMP2 Regulation.2020

    • Author(s)
      Hori M, Shibato J, Horiguchi A, Wakamori M, Numazawa S, Shioda S, Rakwal R.
    • Journal Title

      Proteomics Bioinformatics

      Volume: 2 Pages: 108-119

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide: Protective effects in stroke and dementia.2020

    • Author(s)
      Nonaka N, Banks WA, Shioda S.
    • Journal Title

      Peptides

      Volume: 130 Pages: 170332-170332

    • DOI

      10.1016/j.peptides.2020.170332

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] さくら花びらの主成分であるベンズアルデヒドの生理作用 -桜の花びらの主成分の機能解析-2020

    • Author(s)
      竹ノ谷 文子、柴藤 淳子、福本 勘太、木村 愛、山下 道生、平林 敬浩、千葉 義彦、塩田 清二
    • Journal Title

      日本アロマセラピー学会誌

      Volume: 19 Pages: 21-29

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The polarity and properties of radial glia-like neural stem cells are altered by seizures with status epilepticus: Study using an improved mouse pilocarpine model of epilepsy2020

    • Author(s)
      Sasaki-Takahashi N, Shinohara H, Shioda S, Seki T.
    • Journal Title

      Hippocampus

      Volume: 30 Issue: 3 Pages: 250-262

    • DOI

      10.1002/hipo.23153

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression patterns of PACAP and PAC1R genes and anorexigenic action of PACAP1 and PACAP2 in zebrafish.2019

    • Author(s)
      Nakamachi T, Taniguchi A, Nonno N, Matsuda K
    • Journal Title

      Front Endocrinol

      Volume: - Pages: 227-227

    • DOI

      10.3389/fendo.2019.00227

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced lysosomal degradation maintains the quiescent state of neural stem cells2019

    • Author(s)
      T. Kobayashi, W. Piao, T. Takamura, H. Kori, H. Miyachi, S. Kitano, Y. Iwamoto, M. Yamada, I. Imayoshi, S. Shioda, A. Ballabio, R. Kageyama
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5446-5446

    • DOI

      10.1038/s41467-019-13203-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Towards identification of bioactive compounds in cold vacuum extracted double cherry blossom (Gosen-Sakura) leaves2019

    • Author(s)
      Shibato J, Takenoya F, Hirabayashi T, Kimura A, Iwasaki Y, Toyoda Y, Hori H, Tamogami S, Rakwal R, Shioda S
    • Journal Title

      Plant Signaling & Behavior:

      Volume: 14 Issue: 10 Pages: e1644594-e1644594

    • DOI

      10.1080/15592324.2019.1644594

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurophysiology and treatment of disorders of consciousness induced by traumatic brain injury: orexin signaling as a potential therapeutic target.2019

    • Author(s)
      Tang H, Zhu Q, Li W, Qin S, Gong Y, Shioda S, Li S, Huang J, Liu B, Fang Y, Liu Y, Wang S, Guo Y, Xia Q, Guo Y, Xu Z
    • Journal Title

      Curr Pharm Des .

      Volume: 25 Issue: 39 Pages: 4208-4220

    • DOI

      10.2174/1381612825666191029101830

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] さくら花びらの低温真空抽出液の生理機能解析 ―嗅覚刺激による抗酸化脳とホルモン分泌作用―2019

    • Author(s)
      竹ノ谷 文子、柴藤 淳子、木村 愛、福本 勘太、平林 敬浩、亀井 淳三、塩田 清二
    • Journal Title

      日本アロマセラピー学会誌

      Volume: 18 Pages: 14-21

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 玄米パウダー摂取が陸上長距離選手の抗酸化脳に及ぼす影響2019

    • Author(s)
      琉子 友男、田中 博史、佐藤 貫太郎、只隈 伸也、太田 真、竹ノ谷 文子、平林 敬浩、塩田 清二
    • Journal Title

      運動とスポーツの科学

      Volume: 24 Pages: 125-131

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 嗅覚の低下と認知症および芳香療法について2019

    • Author(s)
      塩田 清二、平林 敬浩、竹ノ谷 文子
    • Journal Title

      老年精神医学雑誌

      Volume: 30 Pages: 137-144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <b>Analgesic effect of mineral cream containing natural spa minerals for use on the </b><b>skin </b>2018

    • Author(s)
      Hirabayashi T, Yamashita M, Wada N, Takenoya F, Ikeda H, Kamei J, Ryushi T, Yamamoto N, Shioda S.
    • Journal Title

      Biomedical Research

      Volume: 39 Issue: 4 Pages: 215-222

    • DOI

      10.2220/biomedres.39.215

    • NAID

      130007432815

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2018-08-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application2018

    • Author(s)
      Shioda S, Takenoya F, Hirabayashi T, Wada N, Seki T, Nonaka N, Nakamachi T.
    • Journal Title

      J Mol Neurosci.

      Volume: - Issue: 3 Pages: 1-7

    • DOI

      10.1007/s12031-018-1087-1

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-stress action of lavender oil and its component analysis of mice and humans.2018

    • Author(s)
      Takenoya F, Mimori A, Hirabayashi T, Shibato J, Kimura A, Shioda S.
    • Journal Title

      J Jpn Soc Aromatherapy

      Volume: 1 Pages: 7-14

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.2018

    • Author(s)
      Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferr&eacute; P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
    • Journal Title

      Cell Rep.

      Volume: 22 Issue: 3 Pages: 706-721

    • DOI

      10.1016/j.celrep.2017.11.102

    • NAID

      120007001417

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain.2018

    • Author(s)
      Nakamachi T, Kamata E, Tanigawa A, Konno N, Shioda S, Matsuda K.
    • Journal Title

      Peptides

      Volume: 103 Pages: 40-47

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin D2 Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle.2018

    • Author(s)
      Suto W, Ando Y, Hirabayashi T, Takenoya F, Shioda S, Kamei J, Sakai H, Chiba Y.
    • Journal Title

      Int J Mol Sci.

      Volume: 19 Issue: 10 Pages: 3036-3036

    • DOI

      10.3390/ijms19103036

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of PACAP and its receptors in the brain.2018

    • Author(s)
      Hirabayashi T, Nakamachi T, Shioda S.
    • Journal Title

      J Headache Pain.

      Volume: 19 Issue: 1 Pages: 28-28

    • DOI

      10.1186/s10194-018-0855-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Feeding Behavior and Energy Metabolism by Galanin-like Peptide (GALP): A Novel Strategy to Fight Against Obesity.2018

    • Author(s)
      Takenoya F, Hirako S, Wada N, Nonaka N, Hirabayashi T, Kageyama H, Shioda S
    • Journal Title

      Curr Pharm Des.

      Volume: 24 Issue: 33 Pages: 3926-3933

    • DOI

      10.2174/1381612824666181106111623

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuropeptides: From Bench to Bedside.2018

    • Author(s)
      Shioda S, Gozes I.
    • Journal Title

      Curr Pharmac Design

      Volume: 24 Issue: 33 Pages: 3867-3867

    • DOI

      10.2174/138161282433190109122611

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progress Toward Rice Seed OMICS in Low-Level Gamma Radiation Environment in Iitate Village, Fukushima2017

    • Author(s)
      Rakwal Randeep、Hayashi Gohei、Shibato Junko、Deepak Saligrama A、Gundimeda Seetaramanjaneyulu、Simha Upendra、Padmanaban Arunkumar、Gupta Ravi、Han Sang-Ik、Kim Sun Tae、Kubo Akihiro、Imanaka Tetsuji、Fukumoto Manabu、Agrawal Ganesh Kumar、Shioda Seiji
    • Journal Title

      Journal of Heredity

      Volume: 109 Issue: 2 Pages: 206-211

    • DOI

      10.1093/jhered/esx071

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dentate granule progenitor cell properties are rapidly altered soon after birth2017

    • Author(s)
      Matsue Kenta、Minakawa Shiori、Kashiwagi Taichi、Toda Keiko、Sato Toru、Shioda Seiji、Seki Tatsunori
    • Journal Title

      Brain Structure and Function

      Volume: 223 Issue: 1 Pages: 357-369

    • DOI

      10.1007/s00429-017-1499-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice.2017

    • Author(s)
      Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, Shioda S, Nagasaka S, Honda K, Izumizaki M.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 10 Pages: e0186637-e0186637

    • DOI

      10.1371/journal.pone.0186637

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation.2017

    • Author(s)
      Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y
    • Journal Title

      Aging Dis.

      Volume: 8 Issue: 6 Pages: 760-777

    • DOI

      10.14336/ad.2016.0620

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development2017

    • Author(s)
      Miura-Yamamoto Y, Shinohara H, Kashiwagi T, Sato T, Shioda S, Seki T
    • Journal Title

      Scientific Reports

      Volume: 7: 5647 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-017-05738-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.2017

    • Author(s)
      Coutinho EA, Okamoto S, Ishikawa AW, Yokota S, Wada N, Hirabayashi T, Saito K, Sato T, Takagi K, Wang CC, Kobayashi K, Ogawa Y, Shioda S, Yoshimura Y, Minokoshi Y
    • Journal Title

      Diabetes

      Volume: 66 Issue: 9 Pages: 2372-2372

    • DOI

      10.2337/db16-1344

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion.2017

    • Author(s)
      Sasaki S, Watanabe J, Ohtaki H, Matsumoto M, Murai N, Nakamachi T, Hannibal J, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S.
    • Journal Title

      Br J Dermatol.

      Volume: 176 Issue: 2 Pages: 413-422

    • DOI

      10.1111/bjd.14885

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of the autonomic nervous system in the tumor- micro-environment and its therapeutic potential.2016

    • Author(s)
      XU Z, SHIODA S, JINUSHI M, KAWAKAMI Y, OHTAKI H, WANG S, ZHAO X, LIU Y, ZHOU D, GUO Y.
    • Journal Title

      Curr Pharm Des.

      Volume: 23 Issue: 11 Pages: 1687-1692

    • DOI

      10.2174/1381612822666161025152942

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bihavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8.2016

    • Author(s)
      WADA N, YAMANAKA S, SHIOBATO J, RAKWAL R, HIRAKO S, IIZUKA Y, KIM H, MATSUMOTO A, KIMURA A, TAKENOYA F, YASUNAGA G, SHIODA S
    • Journal Title

      Genom Data

      Volume: 10 Pages: 38-50

    • DOI

      10.1016/j.gdata.2016.09.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion2016

    • Author(s)
      Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 12034-12034

    • DOI

      10.1038/ncomms12034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide enhances saliva secretion via direct binding to PACAP receptors of major salivary glands in mice.2016

    • Author(s)
      MATOBA Y, NONAKA N, TAKAGI Y, IMAMURA E, NARUKAWA M, NAKAMACHI T, SHIODA S, BANKS WA, NAKAMURA M
    • Journal Title

      Anat Rec (Hoboken)

      Volume: 299 Issue: 9 Pages: 1293-1299

    • DOI

      10.1002/ar.23388

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unlabeling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach.2016

    • Author(s)
      HORI M, KUBO H, SHIBATO J, SAITO T, OGAWA T, WAKAMORI M, MASUO Y, SHIODA S, RAKWAL R
    • Journal Title

      Genom Data

      Volume: 8 Pages: 139-145

    • DOI

      10.1016/j.gdata.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice.2016

    • Author(s)
      KAGEYAMA H, SHIBA K, HIRAKO S, WADA N, YAMANAKA S, NOGI Y, TAKENOYA F, NONAKA N, HIRAKO S, INOUE S, SHIODA S
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28200-28200

    • DOI

      10.1038/srep28200

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve glucose and lipid metabolic dysfuntions with different ways in diabetic KK mice.2016

    • Author(s)
      Nakasatomi M, Kim H, Arai T, Hirako S, Shioda S, Iizuka Y, Sakurai K, Matsumoto A
    • Journal Title

      Obes Res Clin Pract

      Volume: Epub ahead of print Issue: 1 Pages: 29-38

    • DOI

      10.1016/j.orcp.2016.03.012

    • NAID

      120006470025

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Narcolepsy-like sleep disturbance in orexin kcnokout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.2016

    • Author(s)
      MORI T, UZAWA N, IWASE Y, MASUKAWA D, RAHMADI M, HIRAYAMA S, HOKAZONO M, HIGASHIYAMA K, SHIODA S, SUZUKI T
    • Journal Title

      Psychopharmacology (Berl).

      Volume: 233 Issue: 12 Pages: 2343-2353

    • DOI

      10.1007/s00213-016-4282-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.2016

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22373-22373

    • DOI

      10.1038/srep22373

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke.2016

    • Author(s)
      Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
    • Journal Title

      J Mol Neurosci

      Volume: 10 Issue: 2 Pages: 1007-1007

    • DOI

      10.1007/s12031-016-0731-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue.2016

    • Author(s)
      HirakoS, Wada N, Kageyama H, Takenoya F , Izumida Y, Kim H, IizukaY, Matsumoto A, Okabe M, Kimura A, Suzuki M, Yamanaka S, Shioda S.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 1-9

    • DOI

      10.1038/srep21481

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.2016

    • Author(s)
      Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
    • Journal Title

      Neuroscience.

      Volume: 320 Pages: 183-193

    • DOI

      10.1016/j.neuroscience.2016.02.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hepatic lipid accumulation is ameliorated in obese KK mice by dietary sei whale oil.2016

    • Author(s)
      Hirako S, Suzuki M, Kim H, Iizuka I, Matsumoto A, Wada N, Okabe M, Takenoya F, Yasunaga G, Yamanaka S, Miyazaki A, Shioda S.
    • Journal Title

      Fish Sci.

      Volume: 82 Issue: 3 Pages: 509-517

    • DOI

      10.1007/s12562-016-0971-2

    • NAID

      40020863321

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pleiotropic and retinoprotective functions of PACAP.2016

    • Author(s)
      SHIODA S, TAKENOYA F, WADA N, HIRABAYASHI T, SEKI T, NAKAMACHI T
    • Journal Title

      Anat Sci Int.

      Volume: 91 Issue: 4 Pages: 313-324

    • DOI

      10.1007/s12565-016-0351-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autonomic nervous system-mediated effects of GALP on energy metabolism2016

    • Author(s)
      HIRAKO S, WADA N, KAGEYAMA H, TAKENOYA F, INOUE S, SHIODA S
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 148 Issue: 1 Pages: 23-27

    • DOI

      10.1254/fpj.148.23

    • NAID

      130005164793

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] GALP点鼻投与によるマウスのエネルギー代謝調節2021

    • Author(s)
      中岡 健太郎、野中 瑞希、木村 愛、柴藤 淳子、平林 敬浩、山下 道生、平子 哲史、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] PACAPによるPC12 細胞の神経突起伸長誘導の分子機構2021

    • Author(s)
      青木 彩乃、平林 敬浩、柴藤 淳子、山﨑 茉由、橋口 友紀、山下 道生、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳血流に影響を与えるレモングラス芳香成分の機能解析2021

    • Author(s)
      山下 道生、木村 愛、柴藤 淳子、福本 勘太、千葉 義彦、平林 敬浩、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ペパーミントおよびジンジャー精油暴露による摂食調節作用の免疫組織学的検討2021

    • Author(s)
      若井 光、木村 愛、柴藤 淳子、平林 敬浩、山下 道生、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of PACAP on corneal epithelial repair.2020

    • Author(s)
      Seiji Shioda
    • Organizer
      Cornea and Ocular Surface Biology and Pathology, Gordon Research Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] レモングラスによる抗菌・抗ウイルス作用について2020

    • Author(s)
      塩田 清二
    • Organizer
      日本アロマセラピー学会 第23回学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] レモングラス芳香成分の生理作用に及ぼす機能解析2020

    • Author(s)
      山下 道生、木村 愛、柴藤 淳子、福本 勘太、千葉 義彦、平林 敬浩、小林 哲郎、竹ノ谷 文子、塩田 清二
    • Organizer
      日本アロマセラピー学会 第23回学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 低温真空抽出法で得られるサボテンセルエキストラクトの育毛促進効果についての網羅的解析2020

    • Author(s)
      橋口 友紀、柴藤 淳子、木村 愛、竹ノ谷 文子、山下 道生、平林 敬浩、塩田 清二
    • Organizer
      日本アロマセラピー学会 第23回学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] シークヮーサー精油に含まれるノビレチンによる神経前駆細胞増殖能および分化誘導促進作用2020

    • Author(s)
      山崎 茉由、平林 敬浩、橋口 友紀、柴藤 淳子、木村 愛、竹ノ谷 文子、塩田 清二
    • Organizer
      日本アロマセラピー学会 第23回学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ペパーミントおよびジンジャー精油暴露による摂食調節作用の免疫組織学的検討2020

    • Author(s)
      若井 光、木村 愛、柴藤 淳子、平林 敬浩、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本アロマセラピー学会 第23回学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高齢化社会における統合医療~アロマセラピーの効果効能について~2020

    • Author(s)
      塩田 清二
    • Organizer
      美活シンポジウム2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 神経ペプチドPACAPによる角膜上皮の新生・再生作用2020

    • Author(s)
      石川 満理奈、柴藤 淳子、中町 智哉、平林 敬浩、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低温真空抽出によるサボテンセルエキストラクトの育毛促進効果について2020

    • Author(s)
      若井 光、柴藤 淳子、木村 愛、平林 敬浩、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経ペプチドPACAPによる汗分泌促進メカニズムの解析2020

    • Author(s)
      橋口 友紀、山下 道生、山崎 茉由、柴藤 淳子、平林 敬浩、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 柑橘類に含まれるフラボノイド化合物ノビレチンによる神経前駆細胞の細胞増殖能および分化誘導促進作用2020

    • Author(s)
      山﨑 茉由、平林 敬浩、橋口 友紀、柴藤 淳子、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PC12細胞におけるPACAPの突起伸長の分子制御機構2020

    • Author(s)
      石野 茉由子、平林 敬浩、柴藤 淳子、山下 道生、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 喘息モデルマウスにおけるPACAP誘発気管支平滑筋弛緩反応減弱をもたらす因子の探索2020

    • Author(s)
      野村 麻友、安藤 祐介、山下 道生、増山 佑真、上田 千裕、神野 奈緒子、平林 敬浩、竹ノ谷 文子、酒井 寛泰、亀井 淳三、塩田 清二、千葉 義彦
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 喘息モデルマウスの気道局所におけるPACAP含量の変化2020

    • Author(s)
      増山 佑真、安藤 祐介、山下 道生、野村 麻友、上田 千裕、神野 奈緒子、平林 敬浩、竹ノ谷 文子、酒井 寛泰、亀井 淳三、塩田 清二、千葉 義彦
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経ペプチドPACAPによる唾液分泌促進機構の解析2019

    • Author(s)
      山下 道生、平林 敬浩、中町 智哉、矢田 俊彦、吉垣 純子、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      第15回 GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経ペプチドPACAPによる角膜上皮の新生・再生作用2019

    • Author(s)
      石川 満理奈、柴藤 淳子、中町 智哉、平林 敬浩、竹ノ谷 文子、塩田 清二
    • Organizer
      第15回 GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PC12細胞におけるPACAPの突起伸長の分子機構2019

    • Author(s)
      遠藤 沙也花、塩田 美冬、山下 道生、平林 敬浩、柴藤 淳子、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      第15回 GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 喘息時の過敏性気管支平滑筋におけるPACAP受容体Adcyap1r1のダウンレギュレーション2019

    • Author(s)
      神野 奈緒子、上田 千裕、須藤 航、平林 敬浩、竹ノ谷文子、塩田 清二、髙﨑 一朗、酒井 寛泰、千葉 義彦
    • Organizer
      第15回 GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒト汗腺不死化細胞を用いたPACAPの汗分泌促進作用について2019

    • Author(s)
      塩田 美冬、遠藤 沙也花、山下 道生、平林 敬浩、柴藤 淳子、千葉 義彦、竹ノ谷 文子、塩田 清二
    • Organizer
      第15回 GPCR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] サボテン抽出セルエキストラクトの育毛効果について2019

    • Author(s)
      木村 愛、柴藤 淳子、竹ノ谷 文子、山下 道生、平林 敬浩、塩田 清二
    • Organizer
      日本アロマセラピー学会 第22回 学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低温真空抽出法によるさくらセルエキストラクトの美白効果について2019

    • Author(s)
      山下 道生、柴藤 淳子、木村 愛、千葉 義彦、平林 敬浩、竹ノ谷 文子、塩田 清二
    • Organizer
      日本アロマセラピー学会 第22回 学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低温真空抽出法によるさくらの葉セルエキストラクトの抗腫瘍効果と作用機序2019

    • Author(s)
      柴藤 淳子、竹ノ谷 文子、山下 道生、平林 敬浩、塩田 清二
    • Organizer
      日本アロマセラピー学会 第22回 学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低温真空抽出法による美郷雪華(白色ラベンダー)の生理作用について2019

    • Author(s)
      竹ノ谷 文子、柴藤 淳子、木村 愛、山下 道生、千葉 義彦、平林 敬浩、福本 勘太、塩田 清二
    • Organizer
      日本アロマセラピー学会 第22回 学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] さくら花びらの生理作用に及ぼす主成分benzaldehydeの機能解析2019

    • Author(s)
      福本 勘太、竹ノ谷 文子、柴藤 淳子、木村 愛、山下 道生、千葉 義彦、平林 敬浩、塩田 清二
    • Organizer
      日本アロマセラピー学会 第22回 学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] EFFECT OF PACAP ON CORNEAL EPITHELIAL REPAIR -PACAP and dry eye syndrome-2019

    • Author(s)
      Tomoya Nakamachi, Junko Shibato, Takahiro Hirabayashi, Hitoshi Hashimoto, Dora Reglodi, Seiji Shioda
    • Organizer
      The Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] EFFECT OF PACAP ON CORNEAL EPITHELIAL REPAIR2019

    • Author(s)
      Seiji Shioda, Tomoya Nakamachi, Junko Shibato, Takahiro Hirabayashi, Hitoshi Hashimoto, Dora Reglodi
    • Organizer
      Gordon Research Conference, “Cornea and Ocular Surface Biology and Pathology”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of promotion of sweat secretion by PACAP.2018

    • Author(s)
      Hirabayashi T, Endo S, Shioda M, Nakamachi T, Sasaki S, Takenoya F, Harvey BJP, Shioda S.
    • Organizer
      GPCR International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 題 Functional analysis of dry syndrome by PACAP and its prevention and possible use for therapeutic application.2018

    • Author(s)
      Shioda S, Nakamachi T, Hirabayashi T, Takenoya F, Wada N, Nonaka N, Shibato J.
    • Organizer
      GPCR International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 芳香療法による認知症の予防・改善について2018

    • Author(s)
      塩田 清二
    • Organizer
      統合医療シンポジウム 中日統合医療健康美化発表会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高齢化社会における先端医療と新ビジネスの創造 ~認知症予防と芳香療法・再生医療~2018

    • Author(s)
      塩田清二
    • Organizer
      日本経済研究所 平成30年度第会東京講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] さくら香りによる脳機能および生理的解析2018

    • Author(s)
      竹ノ谷 文子、平林 敬浩、山田啓司、倉澤 貴美子、塩田 清二
    • Organizer
      第21回 日本アロマセラピー 学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 「さくら」のセルエキストラクトによる生理作用について2018

    • Author(s)
      竹ノ谷 文子、倉澤 貴美子、山田啓司、塩田 清二
    • Organizer
      第21回 日本アロマセラピー 学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アロマセラピーと地方創生活性化事業について2018

    • Author(s)
      塩田 清二
    • Organizer
      第21回 日本アロマセラピー 学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アロマセラピーによる認知症の予防・改善2018

    • Author(s)
      塩田 清二
    • Organizer
      日本アロマセラピー学会九州地方会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 低温真空抽出法によるさくらセルエキストラクトの美白効果について2018

    • Author(s)
      守谷 友里恵, 柴藤 淳子, 平林 敬浩, 木村 愛, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー性喘息モデルマウスの気管支平滑筋における PACAP 受容体 Adcyap1r1 発現の減少2018

    • Author(s)
      上田 千裕, 神野 奈緒子, 須藤 航, 平林 敬浩, 竹ノ谷 文子, 塩田 清二, 髙﨑 一朗, 酒井 寛泰 , 千葉 義彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経ペプチド PACAP による唾液分泌促進機構の解析2018

    • Author(s)
      山下 道生, 平林 敬浩, 中町 智哉, 矢田 俊彦, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] さくらの香りによる人体への生理作用について2018

    • Author(s)
      福本 勘太, 柴藤 淳子, 平林 敬浩, 山下 道生, 木村 愛, 岩崎 雄介 千葉 義彦, 竹ノ谷 文子 , 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 白色ラベンダー「美郷雪華」の芳香成分による中枢神経系への生理作用2018

    • Author(s)
      野中 瑞希, 木村 愛, 山田 啓司, 福本 勘太, 平林 敬浩, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 汗腺不死化細胞を用いた PACAP の汗分泌促進作用について2018

    • Author(s)
      塩田 美冬, 遠藤 沙也花, 山下 道生, 平林 敬浩, 柴藤 淳子, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PC12 細胞における PACAP の突起伸長の分子機構2018

    • Author(s)
      遠藤 沙也花, 塩田 美冬, 山下 道生, 平林 敬浩 柴藤 淳子, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 虚血再灌流 in vitro 実験系を用いた PACAP の細胞死抑制機構の解析2018

    • Author(s)
      石野 茉由子, 橋口 友紀, 山崎 茉由, 山下 道生, 平林 敬浩, 柴藤 淳子, 千葉 義彦, 竹ノ谷 文子, 塩田 清二
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラベンダー精油による抗ストレス作用について2018

    • Author(s)
      竹ノ谷 文子、平林 敬浩、山本 憲志、琉子 友男、塩田 清二
    • Organizer
      第74回 日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PACAPは角膜障害の治癒を促進する2018

    • Author(s)
      中町 智哉、関 保、平林 敬浩、塩田 清二
    • Organizer
      第14回 GPCR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経ペプチド PACAP による汗分泌促進作用2018

    • Author(s)
      遠藤 沙也花、塩田 美冬、山下 道生、平林 敬浩、 柴藤 淳子、 竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経ペプチド PACAP による角膜上皮の新生・再生作用2018

    • Author(s)
      石川 満理奈、柴藤 淳子、平林 敬浩、石野 茉由子、山下 道生、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アロママスクによる脳機能の活性化2018

    • Author(s)
      塩田 美冬、倉澤 貴美子、遠藤 沙也花、平林 敬浩、山田 啓司、岩崎 雄介、竹ノ谷 文子、塩田 清二
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAP PLAYS AN ESSENTIAL ROLE FOR NEUROGENESIS AND NERVE REGENERATION AFTER BRAIN ISCHEMIA AND SPINAL CORD INJURY2017

    • Author(s)
      Seiji Shioda, Takahiro Hirabayashi, Fumiko Takenoya, Nobuhiro Wada, Nobuko Tokuda, Tomoya Nakamachi
    • Organizer
      13th International Symposium on VIP, PACAP and Related Peptides
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 精油による神経反応性と心理尺度変化の関係2017

    • Author(s)
      倉澤 貴美子、神保 太樹、平林 敬浩、竹ノ谷 文子、塩田 清二
    • Organizer
      第20回 日本アロマセラピー 学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラベンダー精油の抗ストレス作用とその成分分析2017

    • Author(s)
      山田 啓司、平林 敬浩、倉澤 貴美子、竹ノ谷 文子、塩田 清二
    • Organizer
      第20回 日本アロマセラピー 学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経ペプチドPACAPの多彩な生理作用2016

    • Author(s)
      塩田清二
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] エクリン汗腺におけるPACAPの汗分泌促進作用2016

    • Author(s)
      渡邊 潤、佐々木 駿、中町智哉、大滝博和、荒田 悟、本田一穂、塩田清二
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] PACAPはアクアポリン5を介して涙液分泌を促進する2016

    • Author(s)
      中町 智哉、大滝博和、関 保、渡邊 潤、塩田 清二
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neuroprotective and neurogenic effect of PACAP after stroke2016

    • Author(s)
      Nakamachi T, Shioda S
    • Organizer
      Satellite Symposium of REGPEP20162016
    • Place of Presentation
      Rouen, France
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuroprotective effect of PACAP on spinal cord injury through CRMP-2 protein2016

    • Author(s)
      Shioda S
    • Organizer
      REGPEP2016
    • Place of Presentation
      Rouen, France
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] においのセンシング、分析とその可視化、数値化2020

    • Author(s)
      塩田 清二、平林 敬浩、柴藤 淳子、山下 道夫、竹ノ谷 文子
    • Total Pages
      543
    • Publisher
      技術情報協会
    • ISBN
      9784861048104
    • Related Report
      2020 Annual Research Report
  • [Book] イルカの解剖学 身体構造と機能の理解2020

    • Author(s)
      塩田 清二
    • Total Pages
      616
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436285
    • Related Report
      2020 Annual Research Report
  • [Book] 動物学の百科事典2018

    • Author(s)
      塩田 清二
    • Total Pages
      808
    • Publisher
      丸善出版
    • ISBN
      9784621303092
    • Related Report
      2018 Annual Research Report
  • [Book] アロマセラピー学2017

    • Author(s)
      塩田清二
    • Total Pages
      203
    • Publisher
      悠光堂
    • ISBN
      9784906873746
    • Related Report
      2017 Annual Research Report
  • [Book] Pituitary Adenylate Cyclase Activating Polypeptide- Current Topics in Neurotoxicity 112016

    • Author(s)
      WATANABE J, SEKI T, SHIODA S
    • Total Pages
      840
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Pituitary Adenylate Cyclase Activating Polypeptide- Current Topics in Neurotoxicity 112016

    • Author(s)
      OHTAKI H, SHIODA S
    • Total Pages
      840
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳活性化用マスク及び認 症予防治療用マスク2018

    • Inventor(s)
      塩田清二
    • Industrial Property Rights Holder
      塩田清二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] バラ科サクラ属に属する植物の葉の抽出液を含有する抗腫瘍剤2017

    • Inventor(s)
      塩田清二,川人紫
    • Industrial Property Rights Holder
      塩田清二,川人紫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗酸化剤、該抗酸化剤を含有する美白剤、及び該抗酸化剤の製造方法2017

    • Inventor(s)
      塩田清二,川人紫, 椎名正剛
    • Industrial Property Rights Holder
      塩田清二,川人紫, 椎名正剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳活性化用マスク及び認知症予防治療用マスク2017

    • Inventor(s)
      塩田清二
    • Industrial Property Rights Holder
      塩田清二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗酸化剤又は育毛剤の製造方法2017

    • Inventor(s)
      塩田清二,加藤孝義
    • Industrial Property Rights Holder
      塩田清二,加藤孝義
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] バラ科サクラ属に属する植物の葉の抽出液を含有する抗腫瘍製剤2016

    • Inventor(s)
      塩田清二
    • Industrial Property Rights Holder
      塩田清二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 生物由来液獲得方法2016

    • Inventor(s)
      塩田清二
    • Industrial Property Rights Holder
      塩田清二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-30
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-01-27  

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