| Co-Investigator(Kenkyū-buntansha) |
平賀 徹 松本歯科大学, 歯学部, 教授 (70322170)
山下 照仁 松本歯科大学, 総合歯科医学研究所, 准教授 (90302893)
上原 俊介 松本歯科大学, 歯学部, 講師 (90434480)
高橋 直之 松本歯科大学, 総合歯科医学研究所, 特任教授 (90119222)
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| Budget Amount *help |
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2020: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2019: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
This study clarified roles of Wnt signals in the turnover of bone tissue including alveolar bone. We clarify the possibility that Sfrp5 binds to unknown receptors and promotes osteoblast differentiation in addition to its known function as Wnt inhibitors. A new Rot2-Rho-Pkn3-c-Src signal was identified as a signal that regulates the bone resorption activity of osteoclasts. Furthermore, results have been obtained showing that Pkn3 inhibitors can become seeds for new bone resorption inhibitors. We also found that osteoclasts secrete leukemia inhibitory factor (LIF) as a factor that reduces sclerostin expression in osteocytes. From the above, it was clarified that the turnover of bone metabolism may be regulated by molecules such as Sfrp5, Pkn3, and LIF.
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