Molecular epidemiological study of thyroid cancers by international collaboration
| Project/Area Number |
16H02774
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高村 昇 長崎大学, 原爆後障害医療研究所, 教授 (30295068)
中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
サエンコ ウラジミール 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
光武 範吏 長崎大学, 原爆後障害医療研究所, 教授 (50404215)
鈴木 啓司 長崎大学, 原爆後障害医療研究所, 准教授 (00196809)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2018: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2016: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Keywords | 甲状腺がん / チェルノブイリ / 遺伝子多形 / 分子疫学 / 甲状腺癌 / 内分泌学 / 放射線 |
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| Outline of Final Research Achievements |
In collaboration with researchers from research institutions around Chernobyl, we followed up the cohort of radiation-induced pediatric thyroid cancers. We also collected samples from sporadic pediatric thyroid cancers, analyzed genetic polymorphisms, and performed molecular pathological studies. The results suggest that there are differences in associating genetic polymorphisms between radiation-induced and sporadic, as well as differences in age of onset. The molecular pathogenesis of cancers with long latency seems to be different from early cancers, but there are still significant differences from sporadic ones.
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| Academic Significance and Societal Importance of the Research Achievements |
チェルノブイリ原発事故後の知見は、いまだ重要な社会的・学術的価値を生み出しており、今後も日本と周辺国研究機関との協力体制を維持し、調査を継続する必要がある。関係諸機関の世代交代が進む中、本研究課題は、新たな若手人材同士の関係構築にも貢献できた。また、放射線誘発甲状腺がんの発症分子メカニズムに、散発性との違いが少しずつ明らかになりつつあり、被ばくによる発がんについての理解が深まった。
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey2017
Author(s)
Takahashi A, Ohira T, Hosoya M, Yasumura S, Nagai M, Ohira H, Hashimoto S, Satoh H, Sakai A, Ohtsuru A, Kawasaki Y, Suzuki H, Kobashi G, Ozasa K, Yamashita S, Kamiya K, Abe M
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Journal Title
Journal of Epidemiology
Volume: 27
Issue: 4
Pages: 180-185
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima.2017
Author(s)
Iyama K, Matsuse M, Mitsutake N, Rogounovitch T, Saenko V, Suzuki K, Ashizawa M, Ookouchi C, Suzuki S, Mizunuma H, Fukushima T, Suzuki S, Yamashita S.
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Journal Title
Thyroid
Volume: 印刷中
Issue: 6
Pages: 811-818
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine2017
Author(s)
Bogdanova TI, Saenko VA, Hirokawa M, Ito M, Zurnadzhy LY, Hayashi T, Rogounovitch TI, Miyauchi A, Tronko MD, Yamashita S.
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Journal Title
Endocrine Journal
Volume: 64
Issue: 10
Pages: 977-993
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma2017
Author(s)
Nikitski A, Rogounovitch T, Bychkov A, Takahashi M, Yoshiura KI, Mitsutake N, Kawaguchi T, Matsuse M, Drozd VM, Demidchik YE, Nishihara E, Hirokawa M, Miyauchi A, Rubanovitch AV, Matsuda F, Yamashita S, Saenko VA
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Journal Title
Thyroid
Volume: 27(2)
Pages: 224-235
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Inappropriate suppression of thyrotropin concentrations in young patients with thyroid nodules including thyroid cancer: the Fukushima Health Management survey2016
Author(s)
Suzuki S, Nakamura I, Suzuki S, Ohkouchi C, Mizunuma H, Midorikawa S, Fukushima T, Ito Y, Shimura H, Ohira T, Matsuzuka T, Ohtsuru A, Abe M, Yamashita S, Suzuki S
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Journal Title
Thyroid
Volume: 26(5)
Pages: 717-725
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fukushima Health Management Survey Group: Effect of Evacuation on Body Weight After the Great East Japan Earthquake2016
Author(s)
Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Kamiya K, Yamashita S, Abe M
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Journal Title
Am J Prev Med
Volume: 50(5)
Pages: 553-560
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comprehensive Survey Results of Childhood Thyroid Ultrasound Examinations in Fukushima in the First Four Years After the Fukushima Daiichi Nuclear Power Plant Accident2016
Author(s)
Suzuki S, Suzuki S, Fukushima T, Midorikawa S, Shimura H, Matsuzuka T, Ishikawa T, Takahashi H, Ohtsuru A, Sakai A, Hosoya M, Yasumura S, Nollet KE, Ohira T, Ohto H, Abe M, Kamiya K, Yamashita S
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Journal Title
Thyroid
Volume: 26(6)
Pages: 843-851
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fukushima Health Management Survey Group: Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey2016
Author(s)
Ohira T, Takahashi H, Yasumura S, Ohtsuru A, Midorikawa S, Suzuki S, Fukushima T, Shimura H, Ishikawa T, Sakai A, Yamashita S, Tanigawa K, Ohto H, Abe M, Suzuki S
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Journal Title
Medicine (Baltimore)
Volume: 95(35)
Related Report
Peer Reviewed / Open Access
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[Journal Article] The First Meeting of the WHO Guideline Development Group for the Revision of the WHO 1999 Guidelines for Iodine Thyroid Blocking2016
Author(s)
Reiners C, Schneider R, Akashi M, Akl EA, Jourdain JR, Li C, Murith C, Van Bladel L, Yamashita S, Zeeb H, Vitti P, Carr Z
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Journal Title
Radiat Prot Dosimetry
Volume: 171(1)
Pages: 47-56
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 福島の小児および思春期の甲状腺乳頭癌における新規融合癌遺伝子の同定2017
Author(s)
井山慶大, 光武範吏, 松瀬美智子, タチアナ ログノビッチ, ウラジミール サエンコ, 鈴木啓司, 芦澤 舞, 大河内千代, 鈴木 聡, 水沼 廣, 福島俊彦, 鈴木眞一, 山下俊一
Organizer
第90回 日本内分泌学会学術総会
Related Report
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[Presentation] Chernobyl Tissue Bank in Ukraine2016
Author(s)
Tetiana Bogdanova, Laryssa Voskoboynyk, Liudmyla Zurnadzhy, Tetiana Degtyareva, Svitlana Burko, Tamara Guliy, Volodymyr Pushkarov , Gerry Thomas, Mykola Tronko
Organizer
第59回日本甲状腺学会学術集会
Place of Presentation
虎ノ門ヒルズフォーラム（東京都港区）
Year and Date
2016-11-03
Related Report
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[Presentation] Histopathological Studies of Thyroid Cancer in Ukraine, Following the Chernobyl Accident2016
Author(s)
Tetiana Bogdanova, Vladimir Saenko, Liudmyla Zurnadzhy, Alina Brenner, Yuri Nikiforov, Ilya Likhtarov, Victor Shpak, Geraldine Thomas, Kiyohiko Mabuchi, Stephen Chanock, Shunichi Yamashita, Mykola Tronko
Organizer
The 5th International Expert Symposium in Fukushima on Radiation and Health
Place of Presentation
セレクトン福島（福島県福島市）
Year and Date
2016-09-26
Related Report
Int'l Joint Research / Invited
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[Presentation] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma2016
Author(s)
ニキツキー アリャクサンドル, サエンコ ウラジミル, ログノビッチ タチアナ,ビチコブ アンドレイ, 高橋めい子, 吉浦孝一郎, 光武範吏, 川口喬久, 松瀬美智子, ドロズド ワレンチナ, デミドチック ユリ, 西原永潤, 廣川満良, 宮内 昭, ルバノビッチ アレクサンドル, 松田文彦, 山下俊一
Organizer
第89回日本内分泌学会学術総会
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2016-04-21
Related Report
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