Mechanism for the environmental light-induced

• Project/Area Number: 16H03026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clothing life/Dwelling life
• Research Institution: Nara Women's University
• Principal Investigator: Takamata Akira 奈良女子大学, 生活環境科学系, 教授 (00264755)
• Co-Investigator(Kenkyū-buntansha): 森本 恵子 奈良女子大学, 生活環境科学系, 教授 (30220081) ; 杉本 直俊 金沢大学, 医学系, 准教授 (80272954)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
• Keywords: エストロゲン / 摂食行動 / うつ様行動 / 光環境 / 温度環境 / 日内リズム / セロトニン / 環境温 / エネルギー消費 / リズム / 環境温度 / 視交叉上核 / 室傍核下部領域 / 不安様行動 / 生体リズム / 行動

Outline of Final Research Achievements

Estrogen deficiency induced hyperphagia/obesity and increased depression-like behavior, which is possibly cause by the attenuated photosensitivity, and consequently the diminished biological rhythm regulation. At least some of these symptoms were reversed by exposure to high-intensity light during the light phase or adjusting diurnal feeding patterns in estrogen-deficiency rats.
In addition, it has been shown that hyperphagia/obesity and increased depression-like behavior due to estrogen deficiency may be cased by a declined serotonergic function, and the antidepressant fluoxetine may improve these health disorders.

Academic Significance and Societal Importance of the Research Achievements

本研究では、エストロゲン欠乏は過食・肥満、気分障害、睡眠障害を惹き起こすが、これらはエストロゲン欠乏により光感受性が低下し、視交叉上核の活動リズムが乱れることが原因の少なくとも一部であることが示された。明期に高照度の光を浴びること、行動パターンを調整することにより、これらの一部は改善された。したがって、閉経後女性は、生活環境、生活習慣を調節することにより、閉経後の過食・肥満、気分障害、睡眠障害を予防できる可能性が示された。今後、閉経後女性の健康の維持・増進のための生活環境・生活習慣のあり方につながる可能性があり、社会的意義は大きい。

Research Products

• [Int'l Joint Research] University of Sussex(英国)
• [Int'l Joint Research] The John B. Pierce Laboratory/Yale University(米国)
• [Int'l Joint Research] The John B. Pierce Laboratory/Yale University(米国)
• [Int'l Joint Research] The John B. Pierce Laboratory/Yale University(米国)
• [Journal Article] Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats (2020)
  • Author(s): Nishimura Yuri、Mabuchi Kaori、Omura Natsumi、Igarashi Ayako、Miura Megumi、Mima Nanako、Negishi Hiroko、Morimoto Keiko、Takamata Akira
  • Journal Title: Nutrients Volume: 12 Issue: 3 Pages: 849-849
  • DOI: 10.3390/nu12030849
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estradiol Replacement Improves High-Fat Diet-Induced Obesity by Suppressing the Action of Ghrelin in Ovariectomized Rats (2020)
  • Author(s): Yokota-Nakagi Naoko、Takahashi Haruka、Kawakami Mizuho、Takamata Akira、Uchida Yuki、Morimoto Keiko
  • Journal Title: Nutrients Volume: 12 Issue: 4 Pages: 907-907
  • DOI: 10.3390/nu12040907
  • Peer Reviewed / Open Access
• [Journal Article] Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats (2019)
  • Author(s): Kawakami Mizuho、Yokota-Nakagi Naoko、Takamata Akira、Morimoto Keiko
  • Journal Title: The Journal of Physiological Sciences Volume: 69 Issue: 6 Pages: 1029-1040
  • DOI: 10.1007/s12576-019-00723-3
  • NAID: 40022094108
  • Peer Reviewed
• [Journal Article] 水分摂取による熱中症予防の生理的メカニズム (2019)
  • Author(s): 鷹股 亮
  • Journal Title: 食と医療 Volume: 10 Pages: 15-22
  • Peer Reviewed
• [Journal Article] The effect of menstrual cycle phase on foot skin temperature during mild local cooling in young women (2019)
  • Author(s): Yuki Uchida, Koyuki Atsumi, Akira Takamata, Keiko Morimoto
  • Journal Title: The Journal of Physiological Sciences Volume: 69(1) Issue: 1 Pages: 151-157
  • DOI: 10.1007/s12576-018-0629-1
  • NAID: 40021804799
  • Peer Reviewed
• [Journal Article] Estrogen replacement enhances insulin-induced AS160 activation and improves insulin sensitivity in ovariectomized rats. (2018)
  • Author(s): Kawakami M, Yokota-Nakagi N, Uji M, Yoshida KI, Tazumi S, Takamata A, Uchida Y, Morimoto K
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 315 Issue: 6 Pages: E1296-E1304
  • DOI: 10.1152/ajpendo.00131.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women (2018)
  • Author(s): Adler Tessa E.、Usselman Charlotte W.、Takamata Akira、Stachenfeld Nina S.
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 315 Issue: 4 Pages: H925-H933
  • DOI: 10.1152/ajpheart.00188.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Estrogen replacement attenuates stress-induced pressor responses through vasorelaxation via β2-adrenoceptors in peripheral arteries of ovariectomized rats (2018)
  • Author(s): Tazumi Shoko、Omoto Sayo、Nagatomo Yu、Kawahara Mariko、Yokota-Nakagi Naoko、Kawakami Mizuho、Takamata Akira、Morimoto Keiko
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 314 Issue: 2 Pages: H213-H223
  • DOI: 10.1152/ajpheart.00148.2017
  • Peer Reviewed
• [Journal Article] S-equol Exerts Estradiol-Like Anorectic Action with Minimal Stimulation of Estrogen Receptor-α in Ovariectomized Rats (2017)
  • Author(s): Nishimura Yuri、Mabuchi Kaori、Takano Azusa、Hara Yayoi、Negishi Hiroko、Morimoto Keiko、Ueno Tomomi、Uchiyama Shigeto、Takamata Akira
  • Journal Title: Frontiers in Endocrinology Volume: 8 Pages: 281-281
  • DOI: 10.3389/fendo.2017.00281
  • Peer Reviewed / Open Access
• [Journal Article] Body fluid regulation and female reproductive steroids (2017)
  • Author(s): 鷹股 亮
  • Journal Title: JAPANESE JOURNAL OF BIOMETEOROLOGY Volume: 54 Issue: 2 Pages: 57-64
  • DOI: 10.11227/seikisho.54.57
  • NAID: 130006855875
  • ISSN: 0389-1313, 1347-7617
  • Peer Reviewed
• [Journal Article] 摂食調節における性差と性ホルモンの役割 (2017)
  • Author(s): 鷹股 亮、森本恵子
  • Journal Title: 実験医学 Volume: 35 Pages: 945-950
• [Journal Article] Effects of estrogen replacement on stress-induced cardiovascular responses via renin-angiotensin system in ovariectomized rats. (2016)
  • Author(s): Tazumi S, Yokota N, Kawakami M, Omoto S, Takamata A, Morimoto K
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 311 Issue: 5 Pages: R898-R905
  • DOI: 10.1152/ajpregu.00415.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Effects of oral fat stimulation on fat taste perception and preference among Japanese young men and women. (2020)
  • Author(s): Yamauchi Y, Inoshita M, Ueshima K, Uchida Y, Takamata A, Morimoto K.
  • Organizer: Experimental Biology 2019
  • Int'l Joint Research
• [Presentation] Anorectic action of estrogen replacement is not modified by gonadotropin releasing hormone (GnRH) and gonadotropins in ovariectomized rats. (2020)
  • Author(s): Izumi A, Iida K, Shiroi R, Mori Y, Morimoto K, Takamata A.
  • Organizer: 第97回日本生理学会大会
• [Presentation] Mild stress influences estrogen-induced enhancement of sucrose intake in ovariectomized rats (2020)
  • Author(s): Iida K, Izumi A, Shiroi R, Mori Y, Morimoto K, Takamata A.
  • Organizer: 第97回日本生理学会大会
• [Presentation] Effects of oral fatty acid sensitivity depending on menstrual cycle on fat intake in young women. (2020)
  • Author(s): Morimoto K, Yamauchi Y, Mizukami Y, Nakayama H, Ueshima K, Takamata A
  • Organizer: 第97回日本生理学会大会
• [Presentation] The effect of gonadotropin releasing hormone (GnRH) antagonism on feeding behavior in female rats. (2019)
  • Author(s): Izumi A, Hirano A, Iida K, Nouchi M, Fujimaki S, Morimoto K, Takamata A.
  • Organizer: Experimental Biology 2019
  • Int'l Joint Research
• [Presentation] Involvement of the opioid system in the 17β-estradiol-induced enhancement of sucrose intake in ovariectomized rats. (2019)
  • Author(s): Iida K, Kanamori K, Kondo S, Izumi A, Morimoto K, Takamata A.
  • Organizer: Experimental Biology 2019
  • Int'l Joint Research
• [Presentation] Estradiol protects decrease in energy intake under psychosocial stress in ovariectomized rats. (2019)
  • Author(s): Nishimura M, Nishihara S, Kawahara M, Kawakami M, Nakagi N, Yuki Uchida Y, Takamata A, Morimoto K.
  • Organizer: 9th FAOPS Congress
  • Int'l Joint Research
• [Presentation] Effects of estradiol on an orexigenic function of ghrelin in ovariectomized rats fed high-fat diet. (2019)
  • Author(s): Yokota-Nakagi N, Kawakami M, Takahashi H, Takamata A, Uchida Y, Morimoto K.
  • Organizer: 9th FAOPS Congress
  • Int'l Joint Research
• [Presentation] エストロゲンによる快楽性糖摂取促進がエネルギー摂取調節に及ぼす影響-μ オピオイド受容体の関与 (2018)
  • Author(s): 飯田久瑠美、金森好美、近藤沙也加、西村友里、鷹股 亮
  • Organizer: 第3回食欲・食嗜好の分子・神経基盤研究会
• [Presentation] 卵巣摘出ラットにおいて昼間の摂食パターンの調節は、エストロゲン欠乏による過食を 無効にする (2018)
  • Author(s): 野内 瑞生, 藤巻 沙織, 西村 友里, 鷹股 亮
  • Organizer: 第95回日本生理学会大会
• [Presentation] Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome. (2017)
  • Author(s): Adler TE, Usselman CW, Anaeto LC, Schapiro RG, Steele FE, Toffoloni N, Takamata A, Taylor HS, Stachenfeld NS.
  • Organizer: Experimental Biology 2017
  • Place of Presentation: Chicago
  • Year and Date: 2017-04-22
  • Int'l Joint Research
• [Presentation] エストロゲンが誘発する快楽性甘味摂取の増強における血漿グルコースの関与 (2017)
  • Author(s): 近藤沙也加、金森好美、森本恵子、鷹股亮
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松、浜松市
  • Year and Date: 2017-03-28
• [Presentation] 卵巣摘出ラットにおけるエストロゲン補充が快楽性甘味摂取とエネルギー摂取調節に及ぼす影響 (2017)
  • Author(s): 金森好美、近藤沙也加、森本恵子、鷹股亮
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松、浜松市
  • Year and Date: 2017-03-28
• [Presentation] 生活環境、生活習慣と閉経後女性の肥満 (2017)
  • Author(s): 鷹股 亮
  • Organizer: 日本家政学会第69回大会
  • Invited
• [Presentation] Estradiol の食欲調節メカニズムにおける中枢時計の関与 (2017)
  • Author(s): 西村友里、鷹股 亮
  • Organizer: 第2回食欲・食嗜好の分子・神経基盤研究会
• [Presentation] エストロゲンの摂食抑制作用におけるオレキシンの役割 (2017)
  • Author(s): 鷹股 亮、西村友里、金森好美、近藤沙也加
  • Organizer: 第2回食欲・食嗜好の分子・神経基盤研究会
• [Presentation] 環境温が摂食行動に及ぼす影響と体温、活動量との関連 (2017)
  • Author(s): 藤巻沙織、鷹股 亮
  • Organizer: 第 56 回日本生気象学会大会
• [Presentation] Sex difference and role of female reproductive hormones in the regulation of muscle blood flow during sustained handgrip exercise (2016)
  • Author(s): Takamata A, Kawamoto M, Morimoto K, Stachenfeld NS
  • Organizer: The 6th International Sports Science Network Forum in Nagano 2016
  • Place of Presentation: Hotel Buena Vista, Matsumoto
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Book] 解剖生理学 (2020)
  • Author(s): 河田光博、三木健寿、鷹股亮 編
  • Total Pages: 179
  • Publisher: 講談社