Mother-infant interaction of functional flavonoids

• Project/Area Number: 16H03040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Miyazaki
• Principal Investigator: Sakakibara Hiroyuki 宮崎大学, 農学部, 教授 (20403701)
• Co-Investigator(Kenkyū-buntansha): 芦田 均 神戸大学, 農学研究科, 教授 (90201889) ; 榊原 陽一 宮崎大学, 農学部, 教授 (90295197)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 次世代伝承性 / フラボノイド / 機能性 / ケルセチン / アントシアニン / マウス / 胎児 / 抗酸化 / 次世代健康影響 / 脂質 / グルコース / サイトカイン

Outline of Final Research Achievements

In this project, we found that daily consumption of flavonoids increases their absorption rate, and also one of major functions is the effect of lipid metabolism. Therefore, we employed quercetin as candidate flavonoids, and evaluated it’s mother-infant interaction. Consequently, we obtained the following aspects: 1) hepatic triglyceride levels were significantly decreased in the infants from the mother consuming quercetin during the pregnancy, and this effect was remarkable in the groups consuming high-fat diet; 2) mice from mother consumed quercetin were sensitive for high-fat induced overweight comparing with mice from mother not consumed quercetin. In conclusion, our results clearly indicate the importance for mother-infant interaction of functions existed in dietary flavonoids.

Academic Significance and Societal Importance of the Research Achievements

本研究により，妊娠期間中の母体がフラボノイドを摂取すると，その生体調節機能が母体を介して次世代に伝わる可能性が示された。着目すべき点は，フラボノイドが有する抗肥満などの生体調節機能が，母体摂取により影響を受ける可能性が示唆されたことである。したがって，フラボノイドを豊富に含む野菜や果物，ないしはサプリメントを母体が摂取するときには，次世代へ伝わる作用を考慮に入れる必要があると考えた。

Research Products

• [Journal Article] Suitability of a 10% fat diet for use in time-restricted feeding experiments with C57BL/6 mice (2020)
  • Author(s): Matsuyama H., Tanaka W., Yokoyama D., Matsumoto S., Sano T., Yamashita T., Nishimura S., Sakono M., Sakakibara H.
  • Journal Title: Bioactive Compounds in Health and Disease Volume: 3 Pages: 55-65
  • Peer Reviewed / Open Access
• [Journal Article] Daily consumption of black soybean (Glycine max L.) seed coat polyphenols attenuates dyslipidemia in apolipoprotein E-deficient mice (2020)
  • Author(s): Tanaka W., Matsuyama H., Yokoyama D., Yamashita Y., Ashida H., Sakono M., Sakakibara H.
  • Journal Title: Journal of Functional Food Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Subchronic toxicity evaluation of leaves from rabbiteye blueberry (Vaccinium virgatum Aiton) in rats (2019)
  • Author(s): Tanaka Wataru、Yokoyama Daigo、Matsuura Yasushi、Nozaki Masahiko、Hirozawa Naoya、Kunitake Hisato、Sakono Masanobu、Sakakibara Hiroyuki
  • Journal Title: Toxicology Reports Volume: 6 Pages: 272-278
  • DOI: 10.1016/j.toxrep.2019.03.005
  • Peer Reviewed / Open Access
• [Journal Article] Daily Consumption of Bilberry (Vaccinium myrtillus L.) Extracts Increases the Absorption Rate of Anthocyanins in Rats (2018)
  • Author(s): Nohara Chiaki、Yokoyama Daigo、Tanaka Wataru、Sogon Tetsuya、Sakono Masanobu、Sakakibara Hiroyuki
  • Journal Title: Journal of Agricultural and Food Chemistry Volume: 66 Issue: 30 Pages: 7958-7964
  • DOI: 10.1021/acs.jafc.8b02404
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of blueberry leaf and stem extracts on hepatic lipid levels in rats consuming a high-sucrose diet (2018)
  • Author(s): Matsuura Y., Sakakibara H., Kawaguchi M., Murayama E., Yokoyama D., Yukizaki C., Kunitake H., Sakono M.
  • Journal Title: Functional Foods in Health & Disease Volume: 8 Pages: 447-461
  • Peer Reviewed / Open Access
• [Journal Article] Daily consumption of monoglucosyl rutin prevents high-fat diet-induced obesity by suppressing gastric inhibitory polypeptide secretion in mice. (2018)
  • Author(s): Yokoyama D., Tanaka W., Hashizume Y., Tandia M., Sakono M., Shimoi K., Sakakibara H.
  • Journal Title: Functional Foods in Health & Disease Volume: 8 Pages: 353-371
  • Peer Reviewed / Open Access
• [Presentation] Effects of quercetin consumption during pregnancy on lipid metabolism of the offspring in mice (2019)
  • Author(s): Takashima M., Kai C., Tanaka W., Matsuyama H., Sakono M., Sakakibara H.
  • Organizer: The 9th International Conference on Polyphenols and Health
  • Int'l Joint Research
• [Presentation] Effects of polyphenol-rich plants on physiological responses for social stress (2019)
  • Author(s): Sakakibara H., Shimoi K.
  • Organizer: The 9th International Conference on Polyphenols and Health
  • Int'l Joint Research / Invited
• [Presentation] Effects of daily consumption of monoglucosyl-rutin on diet-induced obese mice (2019)
  • Author(s): Tanaka W., Matsuyama H., Yokoyama D., Hashizume Y., Tandia M., Sakono M., Sakakibara H.
  • Organizer: The 9th International Conference on Polyphenols and Health
  • Int'l Joint Research
• [Presentation] Effects of black soybean seed coat extracts on blood lipid levels in ApoE deficient mice (2019)
  • Author(s): Tanaka W., Matsuyama H., Yokoyama D., Ymashita Y., Ashida H., Sakono M., Sakakibara H.
  • Organizer: The 7th International Conference on Food Factors
  • Int'l Joint Research
• [Presentation] Effects of consumption-timing and fat species on body weight gain in C57BL/6 mice (2019)
  • Author(s): Matsuyama H., Tanaka W., Yokoyama D., Nishimura S., Matsumoto S., Sano T., Yamashita T., Sakono M., Sakakibara H.
  • Organizer: The 7th International Conference on Food Factors
  • Int'l Joint Research
• [Presentation] ケルセチン摂取がマウスの母子パラメーターに及ぼす影響 (2018)
  • Author(s): 甲斐 千尋，田中航，横山大悟，窄野昌信，榊原啓之
  • Organizer: 平成30年度 日本栄養食糧学会九州 沖縄支部大会
• [Presentation] お母さんの食事が子たちに与える影響～食事由来フラボノイドが有する機能性の次世代伝承性～ (2018)
  • Author(s): 榊原啓之
  • Organizer: 第17回 石川県立大学 食品科学科 公開セミナー
  • Invited
• [Presentation] 次世代の健康な発育をサポートする母体の食事提言 (2018)
  • Author(s): 榊原啓之
  • Organizer: 第2回宮崎テックプラングランプリ
• [Presentation] 黒大豆種皮抽出物の摂取が脂質代謝・動脈硬化形成へ及ぼす影響 (2018)
  • Author(s): 田中航，松山弘希，横山大悟，山下陽子，芦田均， 窄野昌信，榊原啓之
  • Organizer: 第23回日本フードファクター学会学術集会
• [Presentation] グルコシルルチンはGIPの分泌抑制を介して食事誘発生肥満の進展を抑制する (2018)
  • Author(s): 横山大悟，田中航，橋爪雄志，Mahamadou Tandia， 窄野昌信，下位香代子，榊原啓之
  • Organizer: 第23回日本フードファクター学会学術集会
• [Presentation] Subchronic toxicity evaluation of leaves from rabbiteye blueberry in rats (2018)
  • Author(s): Tanaka W., Yokoyama D., Matsuura Y., Nozaki M., Hirozawa N., Kunitake H., Sakono M., Sakakibara H.
  • Organizer: The 4th International Conference on Pharma and Food
  • Int'l Joint Research
• [Presentation] これからの宮崎県における農と食の進化 (2018)
  • Author(s): 榊原啓之
  • Organizer: みやざきネクストアグリSpring Kitchen
  • Invited
• [Presentation] 妊娠母体のケルセチン摂取は次世代に影響を与えるのか? (2017)
  • Author(s): 柿野佑介，横山大悟，窄野昌信，榊原啓之
  • Organizer: 第３回COC+ みやざきA&Sヒルズ研究会
• [Presentation] ケルセチン摂取がマウスの母子に及ぼす影響 (2017)
  • Author(s): 柿野佑介、窄野昌信、榊原啓之
  • Organizer: 第22回日本フードファクター学会学術集会
• [Presentation] Biological rhythm and bioavailability of functional food ingredients (2017)
  • Author(s): 30.Hiroyuki Sakakibara
  • Organizer: 1 st International Conference on Green Agroindustry and Bioeconomy
  • Int'l Joint Research / Invited
• [Book] エッセンシャル食品化学 (2018)
  • Author(s): 中村 宜督、榊原 啓之、室田 佳恵子
  • Total Pages: 256
  • Publisher: 講談社
  • ISBN: 9784065133415