Development of phosphorus management program for end stage diabetic nephropathy with plasma FGF23 level and vascular endothelial function as markers.
| Project/Area Number |
16H03048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Hyogo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 美紀子 兵庫県立大学, 環境人間学部, 教授 (50314852)
新田 陽子 岡山県立大学, 保健福祉学部, 准教授 (70403318)
田中 更沙 兵庫県立大学, 環境人間学部, 助教 (90733387)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 糖尿病腎症 / 高リン血症 / 血管内皮機能 / FGF-23 / 糖尿病性腎症 / 糖尿病末期腎症 / FGF23 / 栄養学 / 糖尿病末期腎 |
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| Outline of Final Research Achievements |
We analyzed the effects of repetition of hyperphosphatemia generated by a diet rich in phosphorus on vascular function. Renal failure model rats were alternately fed high phosphorus and low phosphorus diet. Despite of the lower total phosphorus intake, repetition of hyperphosphatemia caused a same degree of vascular calcification as rats continuously fed a high phosphorus diet. In addition, dietary fiber given simultaneously with a high phosphorus diet caused suppression of hyperphosphatemia in the model rats. When dietary fiber was ingested for 2 weeks in healthy individuals, it was revealed that flow-mediated Dilation (FMD) was improved in the group where serum phosphorus was high.
In the clinical fields, we investigated phosphorus intake, eating habits and eating awareness of hemodialysis patients, and clarified the nutritional and clinical characteristics of the patients with high serum phosphorus.
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| Academic Significance and Societal Importance of the Research Achievements |
我が国に33万人あまりいる透析患者の死因の1/3は心血管疾患である。透析患者の心血管疾患の発症には高リン血症が大きく関わっている。現代の食生活で利用が増えている加工食品には吸収率の高い無機リンが多い食品添加物が多く含まれている。そこで本研究では無機リンの多い食事の後に発生する一過性の高リン血症に注目し、その血管機能への影響を解析した。ここに本研究の社会的意義がある。
我々は一過性の高リン血症は持続する高リン血症と同程度の血管内皮機能の障害と血管の石灰化を引き起こすことを明らかにした。この結果から腎不全患者では一過性の高リン血症を防ぐ栄養療法の開発を行うことの重要性を明らかにした。
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.2019
Author(s)
Fujii T, Shiozaki Y, Segawa H, Nishiguchi S, Hanazaki A, Noguchi M, Kirino R, Sasaki S, Tanifuji K, Koike M, Yokoyama M, Arima Y, Kaneko I, Tatsumi S, Ito M, Miyamoto KI.
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Journal Title
Clin Exp Nephrol
Volume: 23(3)
Issue: 3
Pages: 313-324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.2019
Author(s)
Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI
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Journal Title
Clin Exp Nephrol.
Volume: in press
Issue: 7
Pages: 898-907
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The food colloid principle in the design of elderly food2016
Author(s)
Nishinari K., Takemasa M., Brenner T., Su L., Fang Y., Hirashima M., Yoshimura M., Nitta Y., Moritaka H., Tomczynska-Mleko M., Mleko S., Michiwaki Y.
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Journal Title
Journal of Texture Studies
Volume: 47
Issue: 4
Pages: 284-312
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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