Acquisition of ADL by a combination approach of brain stimulation and behavior analysis

• Project/Area Number: 16H03201
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Tanaka Satoshi 浜松医科大学, 医学部, 准教授 (10545867)
• Co-Investigator(Kenkyū-buntansha): 鈴木 誠 東京家政大学, 健康科学部, 教授 (80554302)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 心理学 / リハビリテーション / 神経科学 / 脳刺激 / 行動分析 / 脳イメージング / 脳卒中 / 脳機能イメージング / 生体シミュレーション

Outline of Final Research Achievements

Transcranial direct current stimulation (tDCS) is one of cortical stimulation techniques that moderates cortical activity and cognitive and motor function in human. In this project, using electromagnetic computer simulation and electrophysiological and psychological experiments, we developed a novel adjuvant strategy that facilitates for stroke patients to re-acquire activities of daily living through a combination of tDCS and behavioral analysis. This finding would be useful not only for stroke rehabilitation, but also for rehabilitation for neurological disorders such as dementia and Parkinson’s disease.

Academic Significance and Societal Importance of the Research Achievements

電気生理学、電磁界シミュレーション、行動分析を組み合わせた研究により、経頭蓋電気刺激法をリハビリテーションに補完的に用いることによって脳卒中患者の日常生活動作の再獲得を促進する効果的な刺激プロトコルの開発を行った。本研究成果は、脳卒中に限らず、認知症やパーキンソン病等の神経疾患に対するリハビリテーション応用へも可能性が広がるため、波及効果は大きいと考えられる。また、国内の脳卒中患者数は今後も増加が予測されており、日常生活動作をターゲットとした新しいリハビリテーション方法の開発を目指した本研究の社会的意義は大きいと考えられる。

Research Products

• [Int'l Joint Research] Aalto University(フィンランド)
• [Int'l Joint Research] Aalto University(フィンランド)
• [Int'l Joint Research] アルト大学(フィンランド)
• [Int'l Joint Research] 南洋理工大学(シンガポール)
• [Int'l Joint Research] アルト大学(フィンランド)
• [Journal Article] Cost of focality in TDCS: Interindividual variability in electric fields (2020)
  • Author(s): M. Mikkonen, I. Laakso, S. Tanaka, A Hirata
  • Journal Title: Brain stimulation Volume: 13 Issue: 1 Pages: 117-124
  • DOI: 10.1016/j.brs.2019.09.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcranial direct-current stimulation combined with attention increases cortical excitability and improves motor learning in healthy volunteers (2020)
  • Author(s): Yamaguchi Tomofumi、Moriya Kouhei、Tanabe Shigeo、Kondo Kunitsugu、Otaka Yohei、Tanaka Satoshi
  • Journal Title: Journal of NeuroEngineering and Rehabilitation Volume: 17 Issue: 1 Pages: 23-23
  • DOI: 10.1186/s12984-020-00665-7
  • Peer Reviewed / Open Access
• [Journal Article] Skillful Cycling Training Induces Cortical Plasticity in the Lower Extremity Motor Cortex Area in Healthy Persons (2019)
  • Author(s): Tatemoto Tsuyoshi、Tanaka Satoshi、Maeda Kazuhei、Tanabe Shigeo、Kondo Kunitsugu、Yamaguchi Tomofumi
  • Journal Title: Frontiers in Neuroscience Volume: 13 Pages: 927-927
  • DOI: 10.3389/fnins.2019.00927
  • Peer Reviewed / Open Access
• [Journal Article] Can electric fields explain inter-individual variability in transcranial direct current stimulation of the motor cortex? (2019)
  • Author(s): Laakso Ilkka、Mikkonen Marko、Koyama Soichiro、Hirata Akimasa、Tanaka Satoshi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 626-626
  • DOI: 10.1038/s41598-018-37226-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcranial Direct-Current Stimulation Combined with Attention to the Paretic Hand Improves Hand Performance in Stroke Patients: A Double-Blind, Sham-Controlled Study (2018)
  • Author(s): Moriya Kouhei、Yamaguchi Tomofumi、Otaka Yohei、Kondo Kunitsugu、Tanaka Satoshi
  • Journal Title: In: Masia L., Micera S., Akay M., Pons J. (eds) Converging Clinical and Engineering Research Volume: ー Pages: 829-833
  • DOI: 10.1007/978-3-030-01845-0_166
  • ISBN: 9783030018443, 9783030018450
  • Peer Reviewed
• [Journal Article] Impairment in toileting behavior after a stroke. (2018)
  • Author(s): Eri Kawanabe, Makoto Suzuki, Satoshi Tanaka, Shotaro Sasaki, Toyohiro Hamaguchi
  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: 8 Pages: 1166-1172
  • DOI: 10.1111/ggi.13435
  • Peer Reviewed / Open Access
• [Journal Article] The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination (2017)
  • Author(s): Fujimoto S, Tanaka S, Laakso I, Yamaguchi T, Kon N, Nakayama T, Kondo K and Kitada R
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 11 Pages: 173-173
  • DOI: 10.3389/fnbeh.2017.00173
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polarity-independent effects of transcranial direct current stimulation over the bilateral opercular somatosensory region: a magnetoencephalography study. (2017)
  • Author(s): Nakagawa K, Koyama S, Inui K, Tanaka S, Kakigi R, Sadato N
  • Journal Title: NeuroReport Volume: 28 Issue: 13 Pages: 822-827
  • DOI: 10.1097/wnr.0000000000000845
  • Peer Reviewed / Open Access
• [Journal Article] Transcranial direct current stimulation does not affect lower extremity muscle strength training in healthy individuals: a triple-blind, sham-controlled study (2017)
  • Author(s): Maeda K, Yamaguchi T, Tatemoto T, Kondo K, Otaka Y and Tanaka S
  • Journal Title: Frontiers in Neuroscience Volume: 11 Pages: 179-179
  • DOI: 10.3389/fnins.2017.00179
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcranial direct current stimulation improves audioverbal memory in stroke patients (2017)
  • Author(s): Kazuta T, Takeda K, Osu R, Tanaka S, Oishi A, Kondo K, Liu M
  • Journal Title: Am J Phys Med Rehabil Volume: - Issue: 8 Pages: 565-571
  • DOI: 10.1097/phm.0000000000000686
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcranial direct current stimulation over the opercular somatosensory region does not influence experimentally induced pain: a triple blind, sham-controlled study. (2017)
  • Author(s): Koyama S, Nakagawa K, Tanaka S
  • Journal Title: Neuroreport Volume: 28 Issue: 3 Pages: 158-162
  • DOI: 10.1097/wnr.0000000000000723
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Electric fields of motor and frontal tDCS in a standard brain space: A computer simulation study. (2016)
  • Author(s): Laakso I, Tanaka S, Mikkonen M, Koyama S, Sadato N, Hirata A
  • Journal Title: Neuroimage Volume: 137 Pages: 140-151
  • DOI: 10.1016/j.neuroimage.2016.05.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 経頭蓋直流電気刺激の脳卒中リハビリテーションへの応用 (2016)
  • Author(s): 田中悟志
  • Journal Title: The Japanese Journal of Rehabilitation Medicine Volume: 53 Pages: 446-451
  • NAID: 130005166247
  • Acknowledgement Compliant
• [Journal Article] 経頭蓋直流電気刺激法の基礎と応用 (2016)
  • Author(s): 田中悟志
  • Journal Title: 脳科学とリハビリテーション Volume: 16 Pages: 35-41
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 神経科学・心理学に基づいた脳卒中リハビリテーション研究の現状と展望 (2019)
  • Author(s): 田中悟志
  • Organizer: 行動リハビリテーション研究会 第８回年次大会
  • Invited
• [Presentation] 研究成果の社会還元～医療応用を具体例として～ (2019)
  • Author(s): 田中悟志
  • Organizer: 日本認知科学会第36回大会
  • Invited
• [Presentation] Transcranial Direct-Current Stimulation Combined with Attention to the Paretic Hand Improves Hand Performance in Stroke Patients: A Double-Blind, Sham-Controlled Study (2018)
  • Author(s): Moriya K, Yamaguchi T, Otaka Y, Kondo K, Tanaka S
  • Organizer: 4th International Conference on NeuroRehabilitation (ICNR2018)
  • Int'l Joint Research
• [Presentation] 経頭蓋直流電気刺激法（tDCS）の基礎と実践 (2016)
  • Author(s): 田中 悟志
  • Organizer: 第23回脳機能とリハビリテーション研究会学術集会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] 頭蓋直流電気刺激法（tDCS）：実施の方法とポイント (2016)
  • Author(s): 田中 悟志
  • Organizer: 第23回脳機能とリハビリテーション研究会学術集会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] モチベーションの心理学と脳科学 (2016)
  • Author(s): 田中 悟志
  • Organizer: 第4回日本シミュレーション医療教育学会学術大会
  • Place of Presentation: 浜松
  • Invited
• [Remarks] researchmap
  • URL: https://researchmap.jp/tanakasatoshi
• [Remarks] researchmap
  • URL: https://researchmap.jp/tanakasatoshi/
• [Remarks] google scholar
  • URL: https://scholar.google.co.jp/
• [Remarks] google scholar
  • URL: https://scholar.google.co.jp/citations?user=8qpaeBcAAAAJ&hl=ja
• [Remarks] researchmap
  • URL: http://researchmap.jp/tanakasatoshi/