Comprehensive understanding of the neuroplastic mechanisms underlying expert skills
| Project/Area Number |
16H03306
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Brain biometrics
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
HANAKAWA Takashi 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 部長 (30359830)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
林 拓也 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (50372115)
|
|---|
| Research Collaborator |
HORI Yuki
SUGAI Chiaki
UEHARA Kazumasa
KITA Kahori
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Keywords | 学習 / 神経可塑性 / 神経イメージング / MRI / PET / TMS / 磁気共鳴画像 / 経頭蓋磁気刺激 / 小脳 / 大脳基底核 / 脳イメージング / コネクトーム / plasticity / neuroimaging / 神経画像 / 可塑性 |
|---|
| Outline of Final Research Achievements |
The advance of human neuroimaging now allows us to explore macroscopic neuroplasticity non-invasively in humans. Here we performed multi-modal measurement to examine neural correlates of expert skills. We have found that functional connectivity of the putamen codes a skill in piano players. We also found that in novice piano players, 30-min of bilateral piano playing modulates inter-hemispheric inhibition. Moreover, we ran operant conditioning experiments in rats, and measured brain glucose metabolism and structural changes. We found that ventral putamen supports motivation for operant conditioning, and macroscopic neuroplasticity in the cerebellum in rats.
|
| Academic Significance and Societal Importance of the Research Achievements |
ヒトとラットを対象として、マクロ神経可塑性計測を手法として使い、運動学習、音楽や言語など様々なエキスパートの脳の特徴と学習による脳機能構築の変化を明らかにしてきた。特に、マクロ神経可塑性計測はイメージング研究の進歩から生まれた新しい概念であるが、細胞・分子神経科学技術を応用しやすいラットでの再現と実験系の開発は、新しい学術分野の創生につながる成果である。研究の進展により、マクロ神経可塑性の背景にある神経生物学的メカニズムが明らかになれば、学習障害の克服や認知症対策など、大きな社会的インパクトを有する研究が視野に入る。
|
Report
(4 results)
Research Products
(32 results)
-
-
-
-
-
-
-
[Journal Article] Neurite imaging reveals microstructural variations in human cerebral cortical gray matter2018
Author(s)
Fukutomi, H., Glasser, M.F., Zhang, H., Autio, J.A., Coalson, T.S., Okada, T., Togashi, K., Van Essen, D.C., and Hayashi, T.
-
Journal Title
Neuroimage
Volume: in press
Pages: 488-499
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.2018
Author(s)
Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.
-
Journal Title
Anal Biochem
Volume: 549
Pages: 174-183
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] MHC matching improves engraftment of iPSC-derived neurons in non-human primates.2017
Author(s)
Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J.
-
Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 385-385
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Molecular, Functional, and Structural Imaging of Major Depressive Disorder.2016
Author(s)
Zhang, K., Zhu, Y., Zhu, Y., Wu, S., Liu, H., Zhang, W., Xu, C., Zhang, H., Hayashi, T., and Tian, M.
-
Journal Title
Neurosci. bull.
Volume: 32
Issue: 3
Pages: 273-285
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Presentation] 1.Towards the Macaque Connectome: 24-Channel 3T Multi-Array Coil, MR Sequences, and HCP-style Preprocessing2018
Author(s)
Autio Joonas, Ose Takayuki, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Nishigori Kantaro, Yamaguchi Masataka, Hori Yuki, Yoshida Atsushi, Murata Katsutoshi, Glasser Matthew F, Hayashi Takuya
Organizer
ISMRM2018
Related Report
Int'l Joint Research
-
[Presentation] 2.Development of a 24-Channnel 3T Multi-Array Coil for functional MRI in awake monkeys2018
Author(s)
Yoshida Atsushi, Hori Yuki, Nishigori Kantaro, Ohno Masahiro, Kawabata Yoshihiko, Murata Katsutoshi, Urushibata Yuta, Yamaguchi Masataka, Autio Joonas, Glasser Matthew F, Hayashi Takuya
Organizer
ISMRM2018
Related Report
Int'l Joint Research
-
-
-
[Presentation] Translating the Human Connectome Project to Marmoset Imaging2018
Author(s)
Hori Yuki, Autio Joonas, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Murata Katsutoshi, Yamaguchi Masataka, Kawasaki Akihiro, Takeda Chiho, Yokoyama Chihiro, Glasser Matthew F, Hayashi Takuya
Organizer
ISMRM2018
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
