Ultrafast spectroscopic study for visualizing the coupling between electronic excitation and hydrogen-bond dynamics
| Project/Area Number |
16H04102
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical chemistry
|
|---|
| Research Institution | University of Hyogo (2018)
Institute of Physical and Chemical Research (2016-2017) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
|---|
| Keywords | 超高速分光 / ラマン分光 / 核運動 / 非調和結合 / 光受容蛋白質 / 時間分解分光 / フェムト秒パルス / 二次元分光 / コヒーレンス / ラマン / 電子励起状態 / 電子吸収 / 化学物理 |
|---|
| Outline of Final Research Achievements |
We studied the initial nuclear dynamics in a bacterial photoreceptor protein by ultrafast time-domain Raman spectroscopy. Newly developed high-order nonlinear Raman scheme enabled us to observe a distinct anharmonic coupling between the chromophore vibration and the hydrogen-bond motion surrounding the chromophore. The obtained result revealed the molecular mechanism of signal transduction in the primary photoreception process.
|
| Academic Significance and Societal Importance of the Research Achievements |
生体の中で起こる現象を分子レベルで観測することは、生命活動に対する深い理解につながる。このような観点から本研究では、光受容タンパク質の中の様々な部位の原子の動きを観測し、それらの動きどうしの相関を可視化することのできる新たな実験手法の開発に成功した。この成果は今後、生体内での連動した原子・分子の動きがいかにして生体信号を伝え、生命機能を発現および維持させているかという根源的な問いを解明していく手がかりのひとつになると考えられる。
|
Report
(4 results)
Research Products
(77 results)
-
-
-
-
-
-
-
-
[Journal Article] Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates2017
Author(s)
Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano, Yasuteru Urano
-
Journal Title
ACS Chem. Biol.
Volume: 12
Issue: 2
Pages: 558-563
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
