| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
|---|
| Outline of Final Research Achievements |
Optically active compounds are widely used in various fields including medicines, pesticides, and organic materials, but asymmetric synthesis of silicon-stereogenic organosilanes had not been well investigated. In this research, we focused on the development of catalytic asymmetric synthesis of silicon-stereogenic silicon-bridged pi-conjugated compounds and examination of the properties of resulting compounds in the hope of expression of chiroptical properties. As a result, we could achieve the synthesis of various silicon-bridged pi-conjugated compounds such as dibenzosilole derivatives that were difficult to synthesize using existing methods. We could also succeed in obtaining those compounds with high enantioselectivity in many cases. In addition, we could acquire important information on the mechanisms of the reactions we developed as well as optical properties of the compounds we synthesized.
|
