The structural principle of neuronal circuits revealed by the neuronal birthdate tagging approach
| Project/Area Number |
16H04659
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Hirata Tatsumi 国立遺伝学研究所, 遺伝形質研究系, 教授 (80260587)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 誕生日タグづけ / マウス / 神経発生 / 嗅覚系 |
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| Outline of Final Research Achievements |
This study investigated the structural principle of neuronal circuits by making use of a new technique, "neuronal birthdate tagging", which was recently developed by our group. The aim of this technique is to adapt the traditional neuronal classification based on neuronal birthdates to modern neuroscience. With the help of this technique, we can take various advanced approaches such as manipulation of neuronal activities or axon tracing, specifically targeted to a particular neuronal subtype that is defined by the neuronal birthdate. I adapted this technique to three neuronal circuits, 1) central olfactory system, 2) visual system, 3) brain stem reticula formation, all of which are expected to benefit from the neuronal birthdate tagging technique. In this report, I focus on the results obtained in the central olfactory system.
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| Academic Significance and Societal Importance of the Research Achievements |
並列処理は感覚情報処理の基本である。例えば視覚系は、眼で受け取られた視覚風景の中から「色」「線の傾き」「動き」といった異なる特徴を抽出して並列処理することで、エッジの効いた属性情報へと転換し、我々が「物をどう見るべきか」を一義的に決めている。本研究では、代表者が新規開発した「誕生日タグづけ法」を用いることで、嗅覚系にも並列回路が存在することを明らかにした。この結果は、動物が、同一セットの匂い情報の中から、何らかの特徴を抽出し強調して、異なる出力へとつなげる複数のチャネルをもつことを意味している。今後「誕生日タグづけ法」を利用して、嗅覚がもつ複数のチャネルの機能的意味に迫りたい。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Telomere Visualization in Tissue Sections Using Pyrrole-Imidazole Polyamide Probes.2016
Author(s)
Sasaki, A., Ide, S., Kawamoto, Y., Bando, T., Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 29261-29261
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Reallocation of olfactory Cajal-Retzius cells shapes neocortex architecture.2016
Author(s)
de Frutos, C.A., Bouvier, G., Arai, Y., Thion, M.S., Lokmane, L., Maryama, K., Garcia-Dominguez, M., Charnay, P., Hirata, T., Riethmacher, D., Grove, E.A., Tissir, F., Casado, M., Pierani, A., and Garel, S.
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Journal Title
Neuron
Volume: 92
Pages: 435-448
Related Report
Peer Reviewed / Int'l Joint Research
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