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Molecular signaling pathways regulating the formation of nociceptive neuronal network

Research Project

Project/Area Number 16H04660
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kamiguchi Hiroyuki  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (10233933)

Research Collaborator Inoue Mariko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords軸索 / ガイダンス / 表皮 / 神経成長因子 / イノシトール3リン酸 / ホスファチジン酸 / 軸索ガイダンス / 成長円錐 / 痛覚 / イノシトール3リン酸 / カルシウム / 脊髄 / 後根神経節 / ホスホリパーゼD / エキソサイトーシス / ホスホリパーゼ
Outline of Final Research Achievements

During developmental targeting of nociceptive axons toward the skin epidermis, the axon continues to be exposed to increasing concentrations of nerve growth factor (NGF), an attractive cue released from the epidermis. Therefore, the axon should be able to regulate its sensitivity to wide rages of NGF concentrations. This project has identified the IP3 receptor type 3, an intracellular protein that responds to the axon-attractive molecule IP3, as a critical regulator of axonal sensitivity to NGF and of axonal targeting to the skin epidermis. Furthermore, this project has identified phosphatidic acid, an intracellular lipid molecule that mediates attractive axon guidance in the skin through regulating cellular membrane dynamics in the axon.

Academic Significance and Societal Importance of the Research Achievements

痛覚を担う神経細胞の突起(軸索)が皮膚の表面(表皮)へ投射する仕組みを、表皮由来の誘引性分子への感受性制御および軸索細胞内の膜ダイナミクス制御の両面から明らかにした。これらの成果は、神経軸索が細胞外環境の誘引性分子を認識して正しい標的へ到達する仕組みの理解に貢献するとともに、皮膚への神経投射が関与しうる病態(例えば、痒み)のメカニズム解明および治療法開発に寄与しうる成果である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Squaryl group modified phosphoglycolipid analogs as potential modulators of GPR552018

    • Author(s)
      Ding Feiqing、Guy Adam T.、Greimel Peter、Hirabayashi Yoshio、Kamiguchi Hiroyuki、Ito Yukishige
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 61 Pages: 8470-8473

    • DOI

      10.1039/c8cc04467h

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Myosin Va and Endoplasmic Reticulum Calcium Channel Complex Regulates Membrane Export during Axon Guidance2016

    • Author(s)
      Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, Kamiguchi H
    • Journal Title

      Cell Reports

      Volume: 15 Issue: 6 Pages: 1329-1344

    • DOI

      10.1016/j.celrep.2016.04.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclic nucleotide control of microtubule dynamics for axon guidance2016

    • Author(s)
      Akiyama H, Fukuda T, Tojima T, Nikolaev VO, and Kamiguchi H
    • Journal Title

      J. Neurosci.

      Volume: 未定 Issue: 20 Pages: 5636-5649

    • DOI

      10.1523/jneurosci.3596-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Molecular signaling and steering machinery for neuronal growth cone guidance2018

    • Author(s)
      Kamiguchi H
    • Organizer
      ISN-JNC Flagship School
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経回路形成における軸索ガイダンス機構2017

    • Author(s)
      上口裕之
    • Organizer
      東京都医学総合研究所セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) is important for growth cone turning because it controls the asymmetry in Ca2+ elevation in response to guidance cues.2016

    • Author(s)
      Carmen Chan, 秋山博紀、大芦典子、松浦徹、下郡智美、御子柴克彦、上口裕之
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myosin Va-dependent membrane export for axon guidance.2016

    • Author(s)
      和田文孝、上口裕之
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] シングルセル解析プロトコール2017

    • Author(s)
      上口裕之
    • Total Pages
      352
    • Publisher
      羊土社
    • ISBN
      9784758122344
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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