| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
|
|---|
| Outline of Final Research Achievements |
Iron-sulfur (Fe-S) clusters are protein co-factor that are known to have extremely oxygen-labile nature. To elucidate the molecular mechanism involved in the Fe-S cluster biogenesis, in this proposal we focus on its core protein complex. We have been determined the crystal structure of the core complex, thereby the internal cavities were found. The mutagenesis in vivo assay and structural analyses implied that this cavity is probably play a role for the reservoir of iron and/or sulfur species for the de novo Fe-S cluster biosynthesis.
|
