| Budget Amount *help |
¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
Branched glycans attached to proteins play many diverse roles in protein quality control and cell-cell communication etc. Many of the glycan functions are attained through interactions with lectin receptors. However, we still do not know much about the 3D structure and interaction in detail. In this study, we aimed to understand the role of each glycan branch in interacting with lectin receptors. To attain this, we used “branched” glycan unit, not “linear” oligosaccharide as lectin ligands. Here we revealed that lectin receptors are categorized into two types, one binds to both branches irrespective of the branch position, and the other selectively binds to one of the glycan branches.
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