| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Biogenesis of membrane proteins is an essential cellular function. This study aimed to understand molecular mechanism of YidC, a channel-independent protein translocation machinery, which mediates biogenesis of a class of membrane proteins. We have previously found importance of cytoplasmic helices of YidC for its membrane protein insertase function. In this study, we performed genetic analysis and found the importance of basic residues in this region. We also tried to search for small molecule compounds that inhibit YidC activity and were identifying some compounds that might inhibit the activity of YidC.
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